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Oct 07 - 08 2022


All Day

RECORDING – The 10th Annual Thought Leaders Consortium The Intersection of the Intestinal Microbiome with Clinical Epinutrigenomics

Clinical Epigenomics: The Connection Between Immune Aging and the Microbiome

A revolution in disease prevention and reversal

Should premature aging be called a disease? Believe it or not, the question of how to clinically classify aging emerged more than a decade ago. There are many points of view to consider, and it’s a discussion that has been fueled by recent advances in our understanding of the epigenetic and molecular mechanisms involved in biological aging at the cellular, tissue, and organ-specific levels.

We now know that the processes associated with biological aging are connected to age-related chronic diseases, but they are not genetically hard-wired and deterministic. In fact, these processes can be altered through interventions that target specific cellular communication hubs that regulate accelerating biological aging and the pathophenotypes we associate with that phenomenon.

The intervention targets are now being recognized to reside at the critical control points that regulate the epigenetic modulation of immune cell function and its interrelationship with the composition and function of the intestinal microbiome.

From a systems biology perspective, this represents the most upstream point of control of downstream physiological function. It has become clear that the intersection of the regulation of epigenetic control of the immune system with the signals derived from the intestinal microbiome, environment, diet, and lifestyle determine downstream events that regulate the cellular biological aging processes and ultimate health and disease outcomes.

This is the first conference that focuses on the clinical interaction among lifestyle, dietary, and environmental factors influencing the intestinal microbiome and its interaction with the epigenomic regulation of cellular function, emphasizing immunity.

The world-renown faculty for this conference is composed of pioneers and leaders in the development of the fields of discovery covering the microbiome, environmental epigenetics, functional immunology, biological aging, and the role of lifestyle, diet, and specific nutrients in managing clinical conditions associated with chronic immune-related issues.

The clinical objective of this Tenth Annual Thought Leaders Consortium is to provide insights as to the variety of points of potential intervention with personalized lifestyle medicine for remediation of dysfunction that occurs as a consequence of altered communication among the intestinal microbiome, epigenome, and immune and cellular mechanisms that influence senescence and accelerated biological age.

Dr. Jeffrey Bland, PLMI President and host of our annual event and the father of “nutritional epigenomics,” Dr. Randy Jirtle, will introduce and elucidate a clinical concept that may transform patient care in the next decade: the imprintome. Discoveries reveal that the personal imprintome can regulate multiple cellular processes that are associated with how each of us biologically ages. A better understanding of the role of imprintome and its relationship to the function of the intestinal microbiome in upstream regulation and downstream cellular activities represents an exciting new clinical gateway for the management of accelerated aging at its root source. This model can be applied to the management of alterations in immune system function, neurological and endocrine dysfunctions, and conditions related to pulmonary and cardiometabolic functions, all of which are related to the emerging concerns in the post-COVID period.

The Thought Leaders Consortium will feature an expert faculty that is balanced between leading research discoveries and clinical care. As in the previous nine years, this tenth Thought Leaders Consortium will be a dynamic forum for unique interactions and a convergence of ideas among our presenters, attendees, and the conference sponsors

Hourly Schedule

Day One October 7, 2022

7:00am - 7:45am
7:45am - 8:00am
Introduction & Welcome
8:00am - 9:00am
The Epigenome-Microbiome Connection to Immune Function
Jeff Bland, PhD
9:00am - 10:00am
The Science of Hope and the Future of Epigenetics
10:00am - 11:00am
Environmental Epigenetics: Evolution of the field
11:00am - 11:30am
11:30am - 12:00pm
The Measurement of Epigenetic Age and the Methylomb
12:00pm - 12:45pm
Panel discussion/Audience Questions
Jeff Bland, PhD
12:45pm - 1:45pm
1:45pm - 2:15pm
Real World Applications for Nutrigenomics of Metabolic Detoxification
2:15pm - 3:15pm
Phytochemicals and Network Pharmacology
3:15pm - 4:00pm
Advances in Cognitive Neuroimmunology From Mood to Decision-Making: Explorations Through the Lens of Polyphenols and Psychedelics
4:00pm - 4:15pm
4:15pm - 5:00pm
What Is the Future Potential for Environment, Diet and Lifestyle Intervention as an Epigenetic Modulator in Personalized Lifestyle Medicine?
5:00pm - 5:15pm
Closing Comments
Jeff Bland, PhD

Day Two October 8, 2022

7:00am - 7:45am
7:45am - 8:00am
Welcome & Opening
8:00am - 8:30am
The Emerging Understanding of the Impact on the Composition of the Intestinal Microbiome on Immune System Aging
Jeff Bland, PhD
8:30am - 9:30am
The Past, Present and Future Development of Understanding of the Role of the Intestinal Microbiome in Health and Disease
9:30am - 10:00am
The Intestinal Microbiome, Menopause and Weight Gain- An Epigenetic Factor?
10:00am - 10:30am
The Akkermansia Muciniphila Story- From Bench to Bedside
10:30am - 10:45am
10:45am - 11:15am
The Phytochemical-Microbiome-Immune Connection
11:15am - 11:45am
Clinical Pearls-How Do We Tame a Dysbiotic Microbiome?
Jeff Bland, PhD
11:45am - 12:00pm
Q&A Interaction Between the Presenters and the Audience
12:00pm - 1:00pm
1:00pm - 1:45pm
Clinical Approaches to Reversing Immunosenescence, Report on a Senolytic Quercetin/Dasatinib Trial
1:45pm - 2:30pm
Clinical Importance in the Management of the Methylomb
2:30pm - 3:00pm
The Future of Personalized Lifestyle Medicine Applications to Immunosenescence and Metabolic Diseases
Jeff Bland, PhD
3:00pm - 3:30pm
3:30pm - 4:30pm
Patient Communications in the Era of Clinical Epigenomics
4:30pm - 5:00pm
Closing Comments
Jeff Bland, PhD
Jeff Bland, PhD
Jeff Bland, PhD
Functional Medicine Founder and Pioneer
Dr. Jeffrey Bland is a personable and highly respected thought leader who has spent more than four decades focused on the improvement of human health. He is known worldwide as the founder of the Functional Medicine movement, which represents his vision for a care model that is grounded in systems biology and informed by research that he has a unique ability to synthesize. His pioneering work has created the Personalized Lifestyle Medicine Institute (PLMI), as well as the Institute for Functional Medicine (IFM), the global leader in Functional Medicine education. Since 1991, hundreds of thousands of healthcare practitioners have participated in PLMI and IFM programs, and this collective knowledge has positively impacted the lives of patients all over the world. Dr. Bland began his career as a Professor of Biochemistry at the University of Puget Sound. He is a natural educator and became involved with numerous academic institutions during the years he spent teaching. This includes the significant contributions he made to the founding and accreditation of Bastyr University, the first federally accredited university offering undergraduate and graduate degrees in natural medicine in the US. In the early 1980s, Dr. Bland was hand-selected by two-time Nobel Laureate Dr. Linus Pauling to serve as Director of Nutritional Research at the Linus Pauling Institute of Science and Medicine. This experience marked both a personal and professional inflection point for Dr. Bland that has become an integral part of his career. As an expert in a field he helped to establish—science-based nutrition—Dr. Bland has become an iconic figure in the natural products industry. He worked alongside other founders to establish standards for evidence-based formulations, quality ingredient sourcing, and ethical manufacturing practices that stand to this day. He continues to serve as a dynamic mentor and advisor to a new generation of industry leaders. Dr. Bland is the author of best-selling books and over 120 peer-reviewed research publications. He speaks extensively, and his engaging style makes him popular with both professional and consumer audiences. Dr. Bland’s latest project is Big Bold Health, launched in 2018. He’s on a mission to transform the way people think about one of nature’s greatest innovations: the immune system. Through Big Bold Health, Dr. Bland is advocating for the power of immuno-rejuvenation to enhance immunity at a global level. It is an ambitious and purpose-driven effort that encompasses his active stance on regenerative agriculture, environmental stewardship, and planetary health.
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