Clinical Mastery of Hormones: Integrating Metabolites, Metabolism, and Patient Patterns
Course Description
This course provides an in-depth exploration of hormone physiology, regulation, and clinical application, integrating systems biology, laboratory interpretation, and real-world case studies. Participants will learn how to assess, interpret, and apply hormone data with nuance, accounting for metabolism, stress physiology, and clinical outliers.
Learning Objectives
By the end of this course, participants will be able to:
- Understand the scientific methodology behind hormone testing and interpretation
- Apply sex hormone physiology to real-world clinical decision-making
- Interpret estrogen metabolism pathways and clinical implications
- Assess cortisol patterns and the broader cortisome within systems biology
- Navigate complex cases, outliers, and non-linear clinical presentations
Course Modules & Outline
Module 1 Title: Science of Method
Speaker: Mark Newman
Focus: Foundations, testing methodology, and data integrity
Key Topics:
- Overview of hormone testing methodologies (serum, saliva, urine, dried urine, etc.)
- Strengths, limitations, and appropriate use cases of each method
- Analytical validity vs. clinical utility
- Understanding variability, reproducibility, and biological context
- Avoiding common misinterpretations and over-reliance on single data points
Outcomes:
- Participants will understand how hormone data is generated and when it is clinically meaningful
Module 2 Title: Clinical Application of Sex Hormones
Speaker: Dr. Carrie Jones
Focus: Translating physiology into practice
Key Topics:
- Overview of sex hormones (estrogen, progesterone, testosterone, DHEA)
- Life-stage considerations (puberty, reproductive years, perimenopause, menopause, andropause)
- Hormone balance vs. absolute values
- Clinical patterns: deficiency, excess, resistance, and imbalance
- Integrating symptoms, labs, and patient history
Outcomes:
- Participants will gain confidence applying sex hormone knowledge in clinical settings
Module 3 Title: Estrogen Metabolism
Speaker: Dr. Carrie Jones
Focus: Pathways, detoxification, and clinical nuance
Key Topics:
- Estrogen production and metabolism pathways (Phase I & II)
- 2-, 4-, and 16-hydroxy estrogen pathways
- Methylation, glucuronidation, sulfation, and gut involvement
- Clinical implications: estrogen dominance, deficiency, and risk patterns
- Interpreting estrogen metabolites in context (not in isolation)
Outcomes:
- Participants will be able to assess estrogen metabolism patterns and identify clinically relevant concerns
Module 4 Title: Cortisol & the Cortisome
Speaker: Dr. Carrie Jones
Focus: Stress physiology as a systems-wide regulator
Key Topics:
- Cortisol rhythm and regulation
- The cortisome: cortisol’s interaction with immune, metabolic, and sex hormone systems
- Acute vs. chronic stress patterns
- Burnout, HPA-axis dysregulation, and adaptive vs. maladaptive responses
- Clinical interpretation of cortisol curves and patterns
Outcomes:
- Participants will understand cortisol as part of an integrated system rather than a standalone marker
Module 5 Title: Outliers & Case Studies
Speaker: Dr. Carrie Jones
Focus: Complexity, exceptions, and clinical wisdom
Key Topics:
- When “normal labs” don’t match symptoms
- Non-linear hormone responses and paradoxical findings
- Complex cases involving multiple systems
- Red flags, blind spots, and cognitive biases in hormone care
- Clinical reasoning beyond protocols
Outcomes:
- Participants will develop critical thinking skills for complex and atypical hormone cases
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Event Information
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Speakers
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Carrie Jones, ND, FABNE, MPHCarrie Jones, ND, FABNE, MPH is an internationally recognized speaker, consultant, and educator on the topic of women’s health and hormones with over 20 years in the industry. Dr. Jones graduated from the National University of Natural Medicine in Portland, Oregon where she also completed a 2-year residency in women’s health, hormones, and endocrinology. She went on to get her Master of Public Health and was one of the first to became board certified through the American Board of Naturopathic Endocrinology for which she served on for several years. She was the first Medical Director for Precision Analytical, creators of the DUTCH Test and the first Head of Medical Education at Rupa Health and host of the Root Cause Medicine Podcast. She serves as the Clinical Expert for the Lifestyle Matrix Resource Center is on Under Armour’s Human Performance Council. Currently she is the Chief Medical Officer at NuEthix and Head of Medical Education at Metabolic Mentor University.
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Mark Newman, MSMark Newman, MS, is a recognized expert and international speaker in the field of hormone testing. Mark spent nearly 25 years developing and directing 24-hour urine, organic acid, and salivary hormone testing labs. His unique experience led him to pursue a revolutionary way to test hormones. So Mark began his own lab, Precision Analytical Inc., to create the most comprehensive functional hormone test available, DUTCH® (a Dried Urine Test for Comprehensive Hormones). His vision for a better way to test hormones drove Mark to co-write multiple peer-reviewed research papers, which prove the effectiveness and accuracy of dried urine testing to comprehensively evaluate hormone health. Mark is committed to making it easier for patients and their healthcare providers to answer complex clinical questions through extensive education on validated hormone research. Every day, he and his team of experts work toward their mission to profoundly change one life, and then a million more through industry-leading functional hormone testing and education.
