DNA methylation based diagnostics have been expanding as a major focus of research and development in the last few years. Now, this research is finally hitting clinical practice in a major way. In this series, we will talk about the most recent updates and why this is important for the ways you manage your clinics and their health.
This will start with an analysis of DNAm clocks for aging. Over the last 5 years, over 2,000 papers have been published on the association of biological age clocks and outcomes. This has reinforced the importance of biological age! Biological age has been clearly identified as the biggest risk factor for all death and chronic disease. We also know that these clocks are some of the most predictive measures of health span as we age.
However, very little has been done to analyze what we can do to reverse these clocks.
In a recent trial done by Yale and TruDiagnostic, over 75 interventional DNAm studies were analyzed with every DNAm clock. In our first presentation, Dr. Mike Stone will discuss the results of this study. We will talk about how interventions such as stem cells, senolytics, growth hormone, hyperbaric oxygen, rapamycin, metformin and more impact these biological age clocks and by how much.
We will also talk about which clocks stood out as the best and how you can use this data to optimize aging in yourself and your patients. This will be the most comprehensive analysis ever done and will give clinicians an appropriate toolkit to improve aging for the patients you work with.
We also will dive into the newest clocks like OMICmAge (created by Harvard) and SymphonyAge (Created by Yale). These clocks can also give resolution on the “why” we age. As people age in different ways, we need resolution for personalized and individual recommendations. The new clocks can do this and we will show that certain interventions can reverse different organ systems’ ages in different ways.
DNA methylation is also a biomarker that extends way beyond aging. Over the past few years, algorithms using DNA methylation data have been developed to predict disease, predict clinical response to common drugs such as metformin and Semaglutide, predict smoking and drinking status, predicting the amount of lead you have been exposed to throughout a lifetime, and these new algorithms have even made diagnosis like schizophrenia and PTSD available with a clear molecular signature.
We will discuss the newest developments here, particularly discussing the new two clinical tests available which can predict your nutritional status of over 80 different biomarkers like Omega-3 status, toxin and pesticide exposure, and more. Dr. Matt Dawson will then explain how these tests are actually even better than most traditional blood based biomarkers.
This conference will be “one of a kind” in providing insights into this rapidly evolving field from both the research and clinical perspective. Any health care provider interested in the newest and most accurate tools to measure aging and many other disease conditions in a single test will not want to miss this conference. The focus of this conference will be on delivering useful information that can be translated into clinical practice and patient education. You will not want to miss this program.
