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# Personalized Lifestyle Medicine Institute

## Sitemaps

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## Posts

- [A Key to Detecting Hidden Deficiencies and Preventing Chronic Disease: Evaluating Functional Biomarkers and Micronutrient Status](https://plminstitute.org/plmi-blog/a-key-to-detecting-hidden-deficiencies-and-preventing-chronic-disease-evaluating-functional-biomarkers-and-micronutrient-status/) - Micronutrients exist within a dynamic biological system influenced by environment, behavior, physiology, and lived experience. Rather than asking, "Which nutrient is low?"
- [The All-Powerful Omega-3 Fatty Acids](https://plminstitute.org/hot-topics/health-fitness/the-all-powerful-omega-3-fatty-acids/) - Western diets are causing Omega-6 and Omega-3 imbalances to reach a staggering 16 to 1 ratio. The disparity between these two fatty acids has been linked to the rise of cardiovascular disease, cancer and inflammatory diseases. Lowering the imbalance to a 3 to 1 and 2 to 1 ratio, results in many ailments disappearing. A
- [A New Approach to Beauty and Vision](https://plminstitute.org/hot-topics/health-fitness/a-new-approach-to-beauty-and-vision/) - Emerging science reveals that skin health, visual performance, and healthy aging are all connected through a shared biological network — and that supporting it starts in the gut. For decades, skin health and vision health have been viewed as separate concerns. Skin was considered a cosmetic issue, while vision was treated as an eye-specific concern.
- [The Earliest Signs of Cognitive Decline](https://plminstitute.org/hot-topics/personalized-medicine/the-earliest-signs-of-cognitive-decline/) - One of the biggest challenges in cognitive decline is that by the time memory symptoms appear, the disease process has often been unfolding for years. This is one of the central lessons from our movement. Cognitive decline does not begin when someone forgets a name, misses an appointment, or gets lost driving home. Those symptoms
- [The Gut-Brain Connection in Autism: Why Healing the Microbiome Can Transform Neurodevelopmental Health](https://plminstitute.org/hot-topics/immune-health/the-gut-brain-connection-in-autism-why-healing-the-microbiome-can-transform-neurodevelopmental-health/) - In Part 1 of this series, we laid the foundation. We acknowledged the honest state of the evidence, named the five biological pillars that emerge again and again in autism research, and walked through diet, food sensitivities, and broad-spectrum nutritional support. Now we go deeper. If I had to choose only one biological system to
- [These Jobs Could Help Prevent Dementia](https://plminstitute.org/hot-topics/health-fitness/these-jobs-could-help-prevent-dementia/) - New research shows that careers demanding constant navigation, spatial reasoning, and cognitive engagement may reshape the brain in ways that guard against dementia. The science linked to this brain protection matters for everyone. Picture two cab drivers navigating the complex London, thousands of routes memorized, landmarks cross-referenced in real time, ever-shifting traffic anticipated on the
- [Best Functional Medicine Training Programs](https://plminstitute.org/hot-topics/personalized-medicine/best-functional-medicine-training-programs/) - Chronic conditions now account for about 75% of deaths globally, and conventional medicine is struggling to address root causes. Functional medicine is gaining global traction as a clinically sound, evidence-informed approach that emphasizes prevention, personalization, and whole-person care. Providers across medical disciplines are seeking reliable, structured education to integrate these principles into their practices. This comprehensive guide evaluates the
- [Unexplained Infertility: What It Means and Next Steps](https://plminstitute.org/hot-topics/personalized-medicine/unexplained-infertility-what-it-means-and-next-steps/) - Receiving a diagnosis of unexplained infertility can feel disorienting, especially when you’ve gone through testing and everything appears normal, yet pregnancy still hasn’t happened. Many people in this situation do go on to conceive, either naturally or with some support along the way. There are many possible reasons for infertility, and exploring them can offer a
- [The Gut-Brain Axis: Your Body's Most Important Conversation](https://plminstitute.org/hot-topics/health-fitness/the-gut-brain-axis-your-bodys-most-important-conversation/) - For most of human history, the gut and brain were treated as entirely separate systems — one responsible for digestion, the other for thought and feeling. Modern science tells a very different story. The gut and brain are deeply, dynamically connected through a two-way signaling network known as the gut-brain axis — a continuous conversation
- [PLMI Thought Leaders Consortium 2025](https://plminstitute.org/hot-topics/personalized-medicine/plmi-thought-leaders-consortium-2025/) - How inflammation, redox balance, and immune exhaustion shape brain health — and what functional medicine clinicians can do about it. Last week’s TruNeura Mastermind unpacked the highlights from the Personalized Lifestyle Medicine Institute (PLMI) Conference on immunometabolism — where leaders like Dr. Jeffrey Bland, Dr. Dale Bredesen, Dr. Robert Lustig, Dr. David and Austin Perlmutter,
- [The Secret Power of Food Pairing](https://plminstitute.org/hot-topics/health-fitness/the-secret-power-of-food-pairing/) - Imagine if every meal you ate could do more than just fill you up—it could supercharge your health. That’s the idea behind “food synergy,” where combining certain foods can significantly amplify their benefits. When specific foods are eaten together, they don’t just coexist—they interact in ways that magnify their positive effects. This isn’t just a
- [When Hormones and Histamine Collide: Why MCAS Symptoms So Often Worsen in Perimenopause and Menopause](https://plminstitute.org/hot-topics/immune-health/when-hormones-and-histamine-collide-why-mcas-symptoms-so-often-worsen-in-perimenopause-and-menopause/) - If your allergies, hives, flushing, anxiety, or food reactions seem to have ramped up around the same time your cycles started shifting, you are not imagining it, and you are not alone. Science is finally catching up to what so many midlife women have been telling us for years. For a long time, women in
- [The Top Diets for Dementia Prevention According to a Major New Study](https://plminstitute.org/hot-topics/health-fitness/the-top-diets-for-dementia-prevention-according-to-a-major-new-study-2/) - Every week, there’s a new conversation about a superfood, supplement or toxic ingredient for brain health. And as of right now, the significance of almost every one of these topics pales in contrast with the effect of overall dietary patterns. Now a landmark study from the UK Biobank further solidifies this point, tracking over 121,000
- [The Best Functional Medicine Training Programs: A Comprehensive Guide](https://plminstitute.org/hot-topics/personalized-medicine/the-best-functional-medicine-training-programs-a-comprehensive-guide/) - Chronic conditions now account for about 75% of deaths globally, and conventional medicine is struggling to address root causes. Functional medicine is gaining global traction as a clinically sound, evidence-informed approach that emphasizes prevention, personalization, and whole-person care. Providers across medical disciplines are seeking reliable, structured education to integrate these principles into their practices. This comprehensive guide evaluates the
- [Beyond Behavior: A Functional Medicine Roadmap for Autism and Childhood Neurodevelopmental Conditions](https://plminstitute.org/hot-topics/immune-health/beyond-behavior-a-functional-medicine-roadmap-for-autism-and-childhood-neurodevelopmental-conditions/) - In the quiet of my consultation room, I have sat with countless mothers who carry a particular weight in their eyes. They have read the parenting books. They have driven their child to forty hours a week of therapy. They have heard, sometimes from well-meaning professionals and sometimes from family members, that there is nothing
- [Connecting Mitochondrial Health to Gut-Derived Signaling, Cardiovascular Physiology, & Neuroimmune Communication](https://plminstitute.org/plmi-blog/connecting-mitochondrial-health-to-gut-derived-signaling-cardiovascular-physiology-neuroimmune-communication/) - Mitochondria are increasingly understood as central bioenergetic signaling networks that integrate metabolism, immunity, and neural communication across the gut-heart-brain axis. Beyond ATP production, mitochondria help orchestrate inflammatory signaling, redox regulation, immune cell activation, vascular tone, autonomic responsiveness, neuroplasticity, and cellular adaptation to stress through tightly coupled metabolic signaling feedback loops (1-2). From Isolated Disease Models
- [Is Creatine the Best Supplement You’ve Never Tried?](https://plminstitute.org/hot-topics/health-fitness/is-creatine-the-best-supplement-youve-never-tried-2/) - What if there were a supplement that could help protect your muscles and strength as you age, relieve symptoms of depression, and maybe even slow the cognitive decline tied to Alzheimer’s disease? Sounds promising, right? Now, what if I told you that supplement is creatine? If your first thought was, “Isn’t that just for bodybuilders?”,
- [Your Brain Believes What You Tell It About Getting Older](https://plminstitute.org/hot-topics/epigenetics/your-brain-believes-what-you-tell-it-about-getting-older/) - One of the most consistent findings in brain health research is that our brains and by extension their health are majorly impacted by our lives. The brain is exquisitely sensitive to its environment, what you eat, how you sleep, how much you move, how stressed you are. But a compelling and underappreciated line of research
- [AMH Levels: What is Normal and How to Test Anti-Müllerian Hormone](https://plminstitute.org/hot-topics/health-fitness/amh-levels-what-is-normal-and-how-to-test-anti-mullerian-hormone/) - When first exploring fertility or family planning, many people find the acronym AMH, which stands for Anti-Müllerian hormone, quite confusing. If you have recently received your AMH lab results or are just starting to research your reproductive health, you might be wondering exactly what this hormone is and what the results mean for your future. Researching
- [A Chinese Team Has Implanted the World's First Non-Invasive Brain-Computer Interface](https://plminstitute.org/hot-topics/personalized-medicine/a-chinese-team-has-implanted-the-worlds-first-non-invasive-brain-computer-interface/) - One day last October, sitting in the courtyard of his house in China’s Henan province, Dong Hui decided to see if he could hold a pen to write. Dong, 39, had sustained spinal cord injuries in a car accident six years earlier that left him paralyzed from the neck down. Slowly but determinedly, he wrote
- [Membership Models in Cash-Pay Care: 5 Practices Leading the Way](https://plminstitute.org/hot-topics/personalized-medicine/membership-models-in-cash-pay-care-5-practices-leading-the-way/) - Single-tier direct-pay practices are increasingly the exception. Physicians who started with one flat membership fee are layering additional service tiers on top, creating "premium" or "executive" levels at higher prices. Others are keeping insurance contracts for some services while collecting a retainer for enhanced access. These stratified and hybrid arrangements look like product menus, but
- [What Are the Root Drivers of Mitochondrial Dysfunction?](https://plminstitute.org/plmi-blog/what-are-the-root-drivers-of-mitochondrial-dysfunction/) - Mitochondrial dysfunction and impaired cellular bioenergetics are increasingly recognized as shared features across chronic disease, driven by multifactorial upstream influences. At its most fundamental level, health depends on how efficiently energy is generated, transformed, and distributed within living systems. Every physiological and metabolic process—from neuronal signaling and immune regulation to detoxification, repair, and regeneration—relies on
- [7 Surprising Things That Can Cause Alzheimer's Disease](https://plminstitute.org/hot-topics/immune-health/7-surprising-things-that-can-cause-alzheimers-disease/) - Over 44 million people worldwide currently suffer from dementia, and that number is projected to triple in the next 30 years! As the prevalence of Alzheimer’s disease continues to climb, many are sadly watching their loved ones succumb to the disease’s mind vanishing effects. Alzheimer’s has devastating effects on the daily lives of those afflicted
- [Fiber is the Foundation of Everything](https://plminstitute.org/uncategorized/fiber-is-the-foundation-of-everything/) - Most people aren't getting nearly enough fiber — and the microbiome is paying for it. Himalayan Tartary Buckwheat is a nutrient-dense fruit seed delivering rare prebiotic fiber compounds your gut has been waiting for. We've been talking about fiber for decades — eat your vegetables, add some oats, get more roughage. But the conversation has
- [Why Some Patients Don’t Improve, Even When You’re Doing Everything Right](https://plminstitute.org/hot-topics/immune-health/why-some-patients-dont-improve-even-when-youre-doing-everything-right/) - This week’s mastermind walked through a case that highlights one of the most frustrating scenarios in practice: a patient who is doing everything right on paper but continues to decline or react to nearly every intervention. At first glance, the case looked familiar. Longstanding symptoms, high motivation, and a wide range of supportive therapies already
- [The Best Forms of Magnesium—and When to Use Them](https://plminstitute.org/hot-topics/health-fitness/the-best-forms-of-magnesium-and-when-to-use-them/) - Magnesium doesn’t get the attention that vitamin D or omega-3s do, but it should. It’s involved in over 600 enzymatic reactions in the body—everything from your brain fires to how your heart keeps rhythm. It even helps regulate your mood, hormones, blood sugar, and sleep. And yet, most people aren’t getting enough. Maybe even you.
- [Optimizing Fertility: A Functional Medicine Approach to Preparing for Pregnancy](https://plminstitute.org/hot-topics/health-fitness/optimizing-fertility-a-functional-medicine-approach-to-preparing-for-pregnancy/) - Fertility is influenced by far more than timing. From egg and sperm quality to hormones, immune balance, and environmental exposures, conception reflects whole-body health. A functional medicine approach focuses on optimizing these interconnected systems to create a supportive environment for pregnancy—while recognizing that the journey is both biological and deeply personal. Read Article
- [The Top Diets For Dementia Prevention According to A Major New Study](https://plminstitute.org/hot-topics/health-fitness/the-top-diets-for-dementia-prevention-according-to-a-major-new-study/) - Every week, there’s a new conversation about a superfood, supplement or toxic ingredient for brain health. And as of right now, the significance of almost every one of these topics pales in contrast with the effect of overall dietary patterns. Now a landmark study from the UK Biobank further solidifies this point, tracking over 121,000
- [The Network Effect: How Genetic Variants Impact Inflammatory Tone, Antioxidant Defense Capacity, Endocrine Function, & Gut–Environment Interactions](https://plminstitute.org/plmi-blog/the-network-effect-how-genetic-variants-impact-inflammatory-tone-antioxidant-defense-capacity-endocrine-function-gut-environment-interactions/) - Most genetic variants do not act independently, and their effects rarely manifest within a single pathway. Instead, they emerge across interconnected systems (immune signaling, antioxidant defense, endocrine regulation,
- [From Damage to Dysfunction: How a Compromised Stem Cell Repair System Drives Chronic Inflammation & Degenerative Disease](https://plminstitute.org/plmi-blog/from-damage-to-dysfunction-how-a-compromised-stem-cell-repair-system-drives-chronic-inflammation-degenerative-disease/) - Chronic disease does not arise from damage alone. Rather, it reflects a progressive disruption in the body’s ability to repair, regenerate, and maintain tissue integrity.
- [Environmental & Physiological Triggers that Drive Immune Burden](https://plminstitute.org/plmi-blog/environmental-physiological-triggers-that-drive-immune-burden/) - Autoimmune and immune-mediated diseases are rising faster than genetics alone can explain. Over 15% of the U.S. population now has at least one autoimmune diagnosis (1). Immune dysregulation often co-occurs with depression, anxiety, metabolic disease, and chronic inflammatory disorders, reflecting the interplay of immune, endocrine, neural, and metabolic systems (2-3). These clusters point to a
- [From Endocrine Resilience to Oocyte Quality & Placental Development: The Centrality of Mitochondrial Health in Women’s Biology](https://plminstitute.org/plmi-blog/from-endocrine-resilience-to-oocyte-quality-placental-development-the-centrality-of-mitochondrial-health-in-womens-biology/) - Mitochondrial function is a central mechanistic driver of female reproductive capacity, pregnancy outcomes, and endocrine adaptability. Across the female lifespan, from oocyte maturation and early embryogenesis to placental development and midlife hormonal transitions, mitochondria integrate bioenergetic output, redox control, and metabolic signaling. Beyond ATP production, mitochondria regulate redox signaling, calcium homeostasis, steroidogenesis, and apoptotic thresholds
- [Colostrum Supplement Sales Are Booming, But the Science Is Thin](https://plminstitute.org/hot-topics/health-wellness/colostrum-supplement-sales-are-booming-but-the-science-is-thin/) - Celebrity endorsements have driven more than $22 million in US sales, a 3,000% increase from two years earlier. Celebrities are known to take questionable measures to maintain their exceptional hotness. Gwyneth Paltrow intentionally subjected herself to bee stings. Victoria Beckham smeared her face with a cream made from her own blood. Demi Moore used “highly
- [The Systems Biology of Glutathione and Mitochondrial Stress in Cardiometabolic Risk](https://plminstitute.org/plmi-blog/the-systems-biology-of-glutathione-and-mitochondrial-stress-in-cardiometabolic-risk/) - Glutathione sits at the core of cellular redox homeostasis. As the most abundant intracellular antioxidant, reduced glutathione (GSH) functions not merely as a scavenger of reactive oxygen species (ROS), but as a pivotal modulator of redox-sensitive enzymatic activity, mitochondrial integrity, inflammatory signaling, and metabolic resilience and flexibility. When glutathione synthesis or recycling becomes impeded, the
- [The Physiologic Narrative: How Wearable Biometrics Map Endocrine and Metabolic Health](https://plminstitute.org/plmi-blog/the-physiologic-narrative-how-wearable-biometrics-map-endocrine-and-metabolic-health/) - Heart rate variability (HRV), sleep architecture, glucose variability, and activity patterns function as continuous markers of systems-level regulation, reflecting coordinated endocrine, metabolic, autonomic, circadian, and mitochondrial function, capturing how these systems dynamically coordinate energy allocation, stress adaptation, and homeostasis over time, rather than isolated behaviors or symptoms. Individually, each measure provides limited clinical insight. Interpreted
- [Decoding the Crosstalk Between Metabolism and the Endocrine System to Identify Meaningful Patterns in Hormonal Imbalance](https://plminstitute.org/plmi-blog/decoding-the-crosstalk-between-metabolism-and-the-endocrine-system-to-identify-meaningful-patterns-in-hormonal-imbalance/) - Metabolism and endocrine function are deeply interconnected, forming a dynamic system that governs nearly every aspect of physiology. From energy production and tissue remodeling to reproductive capacity, stress adaptation, inflammation regulation, and cognitive resilience, these systems communicate continuously. Understanding hormonal imbalance requires assessing how metabolic conditions influence hormone synthesis, signaling, clearance, and tissue responsiveness. Even
- [This Molecule Grows Your Brain](https://plminstitute.org/hot-topics/personalized-medicine/this-molecule-grows-your-brain/) - Your brain is an incredible network of over 160 billion cells linked by over 100 trillion connections. Each day and each moment, it’s being influenced by the choices you make. While no single signal or chemical determines your brain’s fate, incredible scientific research over the last few decades have revealed that a certain molecule produced
- [Heavy Metals in Protein Powders: Exposure Risks, Testing Standards, and Clinical Guidance](https://plminstitute.org/hot-topics/health-fitness/heavy-metals-in-protein-powders-exposure-risks-testing-standards-and-clinical-guidance/) - Protein powders are a convenient way for many people to meet daily protein needs, especially for those with high activity levels, low appetite, limited time, or therapeutic diets. With rising use, questions about quality and safety have also grown. Independent testing and quality reviews have revealed that some powders contain trace amounts of heavy metals,
- [Perimenopause Weight Gain](https://plminstitute.org/hormone-health/perimenopause-weight-gain/) - Perimenopause is a natural stage of life, and with it often come changes in weight and body composition. While these shifts can sometimes feel discouraging, they are not a reflection of your effort or self-worth. Instead, they’re a signal of the incredible hormonal transitions your body is going through. By learning more about why these
- [How to train Chat-GPT and other AI engines to send patients to your Functional Medicine practice](https://plminstitute.org/hot-topics/technology/how-to-train-chat-gpt-and-other-ai-engines-to-send-patients-to-your-functional-medicine-practice/) - Inside the TruNeura Mastermind: What every practitioner needs to know about AI visibility, patient onboarding, and preparing your practice for the next wave of digital discovery. Last week’s TruNeura Mastermind tackled a question that every forward-thinking clinician should be asking right now: How will patients find my practice in an AI-first world? The conversation, led
- [Your Protein Shake Safety Questions Answered: Finding Clean, Non-Toxic Alternatives](https://plminstitute.org/hot-topics/health-fitness/your-protein-shake-safety-questions-answered-finding-clean-non-toxic-alternatives/) - The Shocking Truth About Protein Powder Contamination If you're like millions of health-conscious Americans who start their day with a protein shake, recent headlines might have you second-guessing your morning routine. Consumer Reports' investigation found that more than two-thirds of 23 tested protein powders contained more lead in a single serving than experts say is
- [Key Mechanisms of Disrupted Immunometabolic Function that Drive Chronic Disease](https://plminstitute.org/plmi-blog/key-mechanisms-of-disrupted-immunometabolic-function-that-drive-chronic-disease/) - Chronic diseases increasingly arise from dysregulation of immunometabolic function, the intricate interplay between metabolism, immune signaling, and cellular communication. When this network becomes imbalanced, persistent inflammation, mitochondrial dysfunction, neuroimmune dysregulation, and gut microbiota imbalances intersect to drive the development and progression of conditions such as obesity, type 2 diabetes, cardiovascular disease, neurodegenerative disorders, autoimmune conditions,
- [AI in Integrative Medicine: Advancing Chronic Disease Prediction and Personalized Prevention](https://plminstitute.org/hot-topics/personalized-medicine/ai-in-integrative-medicine-advancing-chronic-disease-prediction-and-personalized-prevention/) - Chronic diseases such as cardiovascular illness, diabetes, and cancer account for the majority of global deaths, yet a large proportion of these conditions are preventable with early detection and sustained lifestyle support. Integrative medicine, which combines conventional and complementary therapies, focuses on prevention, whole-person health, and patient empowerment. Artificial intelligence (AI) is emerging as a
- [Why Gratitude Might Be the Most Underrated Longevity Tool](https://plminstitute.org/hot-topics/lifestyle-medicine/why-gratitude-might-be-the-most-underrated-longevity-tool/) - In mere minutes a day, one short, but powerful daily practice can help you to achieve all of the following: Improve sleep quality. Break stubborn habits, including tobacco consumption. Reach lifestyle goals, such as eating more veggies or taking the recommended number of daily steps. Manage stress. Boost mood. Fortify your relationships. Reduce risk for
- [Neuroinflammation and the Immunometabolic Brain](https://plminstitute.org/plmi-blog/neuroinflammation-and-the-immunometabolic-brain/) - The brain functions as a dynamic regulator, continuously integrating metabolic, immune, and environmental signals. Emerging evidence shows that systemic energy imbalance extends its effects to the central nervous system, as metabolic stress can activate neuroinflammatory pathways, altering motivation, cognition, and emotional regulation (1–3). The concept of the immunometabolic brain describes the network through which metabolic
- [From Inevitable to Modifiable: Leveraging Biomarkers for Personalized Strategies to Optimize Health and Reduce Disease Susceptibility](https://plminstitute.org/plmi-blog/from-inevitable-to-modifiable-leveraging-biomarkers-for-personalized-strategies-to-optimize-health-and-reduce-disease-susceptibility/) - Ongoing advances in systems biology, neuropsychiatry, and precision medicine have reframed aging and disease susceptibility as dynamic, modifiable processes rather than inevitable outcomes. Core biomarkers—including DNA methylation, histone modifications, telomere attrition, inflammatory signaling, immune-cell distribution, cellular replication, metabolic parameters, and epigenetic or phenotypic aging rate—can be favorably influenced through nutrition, exercise, sleep, circadian alignment, stress
- [CBD and the Root Cause Revolution in Alzheimer’s Care](https://plminstitute.org/hot-topics/personalized-medicine/cbd-and-the-root-cause-revolution-in-alzheimers-care/) - For decades, Alzheimer’s research has revolved around two culprits — amyloid plaques and tau tangles. Yet even as billions have been spent chasing these targets, meaningful recovery remains elusive. Dr. Babak Baban’s recent work — showing how CBD can reduce inflammation and restore immune balance in Alzheimer’s models — points toward a new way forward:
- [How to Eat 12 Servings of Vegetables a Day](https://plminstitute.org/hot-topics/health-fitness/how-to-eat-12-servings-of-vegetables-a-day/) - When many people learn that I recommend 12 to 18 daily servings of non-starchy vegetables—the equivalent of 6 to 8 cups—they tell me, “That’s not remotely possible!” I understand the pessimism. Most people consume only 1-½ cups a day—a mere sixth of what I recommend.¹ Only about 12% of adults hit the U.S. government’s much
- [The Simple Way to Double Your Daily Steps](https://plminstitute.org/hot-topics/health-fitness/the-simple-way-to-double-your-daily-steps/) - Some of the most powerful health advice is so basic, many people tune it out. “Take more daily steps” is a perfect example. For lots of folks, it sounds too simple and easy to work. But the science is hard to argue with: Every additional 1,000 steps you take per day lowers your risk of
- [30 Best Menopause Supplements](https://plminstitute.org/uncategorized/30-best-menopause-supplements/) - The journey through perimenopause and menopause can feel like navigating a complex maze of symptoms, and finding relief can feel overwhelming. Menopause is a stage in a woman's life when her menstrual periods stop and her hormone levels decrease. It typically affects women between the ages of 45 and 55, but it can happen earlier. It
- [Wearable Technologies in Chronic Disease: Clinical Applications and URL: Outcomes](https://plminstitute.org/hot-topics/personalized-medicine/wearable-technologies-in-chronic-disease-clinical-applications-and-url-outcomes/) - Chronic diseases like diabetes, heart failure, and hypertension don’t just affect lab results—they shape daily life, strain families, and challenge clinicians to provide care that keeps up. In a world where over 70% of global deaths stem from chronic illnesses, patients need more than prescriptions. They need ongoing support, visibility, and connection. Wearable health technologies
- [How Do Epigenetic Biomarkers Predict Disease & Aging?](https://plminstitute.org/plmi-blog/how-do-epigenetic-biomarkers-predict-disease-aging/) - Why do some people thrive into their eighties with sharp cognition and resilient health, while others develop cardiovascular disease, memory decline, or autoimmune disorders decades earlier? Why do identical twins, born with the same DNA, often experience vastly different health trajectories? These questions challenge the long-held assumption that genetics alone determines aging and disease. From
- [Post-Pill PCOS](https://plminstitute.org/hot-topics/health-fitness/post-pill-pcos/) - When you stop birth control, it can leave you feeling off with a range of symptoms, and you might wonder if it's a condition like Polycystic Ovary Syndrome (PCOS). This common experience is often referred to as "post-pill PCOS" and can be both confusing and distressing. This article discusses the effects on your body after stopping
- [The Best Beverages for Brain Health](https://plminstitute.org/hot-topics/epigenetics/the-best-beverages-for-brain-health/) - The average adult drinks around 10-11 cups of beverages a day. What we drink can be relatively neutral, healthful or harmful to our brains. What you sip each day may do more for your brain than you realize. While sugary sodas and alcohol can chip away at cognition, coffee and tea consistently rise to the
- [Vagus Nerve Stimulation: Mechanisms and Multifaceted Clinical Applications of a Systems-Level Intervention](https://plminstitute.org/plmi-blog/vagus-nerve-stimulation-mechanisms-and-multifaceted-clinical-applications-of-a-systems-level-intervention/) - As a central component of the parasympathetic nervous system, the vagus nerve helps regulate homeostasis across the body and mind. When engaged to improve vagal tone, it can induce far-reaching health effects. Vagus nerve stimulation (VNS) has evolved from a specialized therapy into a multifaceted neuromodulatory approach that engages multiple pathways to improve health. A
- [The Hidden Crisis in America’s Babies: Why 25% of Infants Lack Critical Gut Bacteria](https://plminstitute.org/hot-topics/epigenetics/the-hidden-crisis-in-americas-babies-why-25-of-infants-lack-critical-gut-bacteria/) - What if I told you that 1 in 4 American babies is missing one of the most important bacteria for their lifelong health? What if this invisible deficit was setting them up for allergies, asthma, eczema, and other chronic diseases later in life? As a functional medicine physician who has spent decades studying the gut-brain-immune
- [The Hard Truth About Processed Carbs](https://plminstitute.org/hot-topics/epigenetics/the-hard-truth-about-processed-carbs/) - Here’s a FREE special report for you: The Hard Truth About Processed Carbs. I hope you’ll download and read it right now. It’s that important. Why? Because it explains why processed refined carbs aren’t just “empty calories”—they’re one of the biggest food enemies to your health, and a major driver of today’s health crisis. The
- [What Will It Take for a New Standard of Care in Cognitive Decline?](https://plminstitute.org/hot-topics/health-fitness/what-will-it-take-for-a-new-standard-of-care-in-cognitive-decline/) - This week I came across an article about Lequembi, a treatment for Alzheimer’s disease. It is a new formulation of Lecanemab and what stood out was how simple it has become to administer. Patients can now inject it themselves at home. It represents the culmination of decades of pharmaceutical development: a drug that’s easier than
- [Beyond Symptoms: Using Advanced Biomarkers for Early Detection and Root Cause Resolution of Cardiovascular Disease](https://plminstitute.org/plmi-blog/beyond-symptoms-using-advanced-biomarkers-for-early-detection-and-root-cause-resolution-of-cardiovascular-disease/) - Atherosclerotic cardiovascular disease (ASCVD) remains a leading global cause of morbidity and mortality, with prevalence projected to rise nearly 90% by 2050 (1–2). Conventional medicine often intervenes when symptoms are overt or a diagnosis is confirmed—addressing hypertension, dyslipidemia, or other risk factors once they surface—overlooking upstream biological stressors that drive vascular dysfunction years before symptoms
- [Can Hormone Monitoring Play a Role in Improving Menstrual Symptoms?](https://plminstitute.org/plmi-blog/can-hormone-monitoring-play-a-role-in-improving-menstrual-symptoms/) - Hormones are the body’s master regulators, orchestrating metabolism, immunity, mood, and cognition. The menstrual cycle—recognized as the “fifth vital sign” (1–3)—offers a dynamic and accessible window into hormonal health. Subtle shifts in cycle length, ovulation, or luteal hormone production can manifest as cramps, bloating, migraines, mood swings, or fatigue, often reflecting deeper metabolic, endocrine, or
- [Endometriosis Supportive Therapy](https://plminstitute.org/hot-topics/health-fitness/endometriosis-supportive-therapy/) - David Letsa, MD Endometriosis is a long-lasting condition in which tissue similar to the lining of the uterus grows outside of it. It mainly affects women of reproductive age and can cause severe pain, difficulties getting pregnant, and significant daily challenges. Understandably, living with endometriosis can present unique challenges, but it's essential to know that
- [The Role of Environmental Toxins in Epigenetic Dysregulation](https://plminstitute.org/plmi-blog/the-role-of-environmental-toxins-in-epigenetic-dysregulation/) - Human health is inextricably linked to the environment, yet this balance is increasingly disrupted by widespread exposure to environmental toxins. Since the 1970s, over 87,000 chemicals have been approved for commercial use in the U.S., with most lacking robust evaluation for long-term biological effects (1). Today, individuals are chronically exposed to complex mixtures of toxicants
- [The Best and Worst Sweeteners for Brain Health](https://plminstitute.org/hot-topics/epigenetics/the-best-and-worst-sweeteners-for-brain-health/) - By Austin Perlmutter, MD Sugar is among the most popular villains in nutritional health conversations. But depending on the content you consume, you may have heard everything from “it’s harmless in moderation” to a suggestion that it’s comparable to cocaine for addictiveness. When it comes to brain health and the effect of sugar on our
- [Mast Cell Activation Syndrome: The Hidden Culprit Behind Mysterious Multi-System Symptoms](https://plminstitute.org/hot-topics/immune-health/mast-cell-activation-syndrome-the-hidden-culprit-behind-mysterious-multi-system-symptoms/) - Dr. Jill C. Carnahan, MD, ABIHM, IFMCP Have you ever experienced seemingly unrelated symptoms affecting multiple body systems—unexplained rashes, digestive issues, brain fog, heart palpitations—that doctors can't quite figure out? You might have been told it's “all in your head” or given a patchwork of diagnoses that don't quite explain the full picture of your
- [What Chronic Inflammation Really Does to Your Body](https://plminstitute.org/hot-topics/health-fitness/what-chronic-inflammation-really-does-to-your-body/) - You hear the word “inflammation” everywhere—in podcasts, on social, and in every corner of healthcare, from your dentist to your cardiologist. But it’s not just a trendy topic. I’ve been raising concerns about it for more than two decades. Still, you might wonder, ‘What does inflammation actually mean?’ Most people know it’s not good. But
- [When the Brain Fails Us: Understanding the Tamura Case](https://plminstitute.org/hot-topics/epigenetics/when-the-brain-fails-us-understanding-the-tamura-case/) - On July 28, 2025, 27‑year‑old Shane Tamura carried out a deadly shooting inside the NFL’s headquarters in Midtown Manhattan, killing four people—including an off-duty NYPD officer—and then himself. His three‑page suicide note claimed he suffered from chronic traumatic encephalopathy (CTE), requested his brain be studied after death, and blamed the NFL for his condition. Although Tamura played
- [Natural Plant Compounds Show Promise for Immune Aging, New Research Reveals](https://plminstitute.org/hot-topics/epigenetics/natural-plant-compounds-show-promise-for-immune-aging-new-research-reveals-2/) - A new study published in Frontiers in Nutrition has revealed how compounds from an ancient grain might help address age-related immune decline. The research, titled "The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age: A Pilot Clinical Study," investigated how dietary components from Tartary buckwheat influence immune aging through epigenetic
- [Restoring Balance: A Deep Dive into Harnessing Nitric Oxide for Menopausal Health and Well-being](https://plminstitute.org/plmi-blog/restoring-balance-a-deep-dive-into-harnessing-nitric-oxide-for-menopausal-health-and-well-being/) - Menopause is marked by a substantial decline in endogenous estrogen, triggering a cascade of physiological alterations across vascular, neurological, immune, and reproductive systems. One critical, yet underappreciated consequence is the reduction in nitric oxide (NO) synthesis. This is significant because NO, a gaseous signaling molecule produced via nitric oxide synthase (NOS), plays essential roles in
- [Is Creatine the Best Supplement You’ve Never Tried?](https://plminstitute.org/hot-topics/health-fitness/is-creatine-the-best-supplement-youve-never-tried/) - What if there were a supplement that could help protect your muscles and strength as you age, relieve symptoms of depression, and maybe even slow the cognitive decline tied to Alzheimer’s disease? Sounds promising, right? Now, what if I told you that supplement is creatine? If your first thought was, “Isn’t that just for bodybuilders?”,
- [Glutathione’s Role in Health: From Mitochondria to Metabolism](https://plminstitute.org/plmi-blog/glutathiones-role-in-health-from-mitochondria-to-metabolism/) - Glutathione (GSH) is one of the most critical molecular determinants of cellular resilience and systemic health. As a direct antioxidant, redox buffer, and essential enzymatic cofactor, GSH supports mitochondrial integrity, facilitates detoxification, modulates immune responses, and contributes to the repair of oxidative damage. Although its physiological importance is well established, recent advances—described in the comprehensive
- [3 Easy Sleep Experiments That Actually Work](https://plminstitute.org/hot-topics/epigenetics/3-easy-sleep-experiments-that-actually-work/) - There’s no shortage of advice for better sleep. And a lot of it can help—if you’re able to do it consistently. But when you're tired, wired, or both, even good habits can be hard to implement all at once. That’s why, for a lot of people, it can be more useful to treat sleep improvement
- [Mold and Your Brain: The Surprising Connection Between Fungal Exposure and Neurological Health](https://plminstitute.org/hot-topics/health-fitness/mold-and-your-brain-the-surprising-connection-between-fungal-exposure-and-neurological-health/) - Have you ever walked into a damp, musty building and immediately felt “off”? Perhaps you experienced a sudden headache, difficulty concentrating, or even anxiety that seemed to come from nowhere. While many dismiss these reactions as imagination or coincidence, mounting scientific evidence suggests these responses may be your body's legitimate warning system. As a functional
- [Keys to the Gut-Brain Connection](https://plminstitute.org/hot-topics/health-fitness/keys-to-the-gut-brain-connection/) - For far too long, we’ve treated the brain as somehow separate from the rest of the body. We’ve acted as though what happens in our body doesn’t influence our brain biology, doesn’t change our mental health or our cognitive abilities. But now, armed with the last few decades of research, there can be no doubt
- [hCG Levels & Twins: Understanding a Pregnancy with Multiples](https://plminstitute.org/hot-topics/health-fitness/hcg-levels-twins-understanding-a-pregnancy-with-multiples/) - The infamous pregnancy hormone, human chorionic gonadotropin (hCG for short), is one of the most important hormones required for a successful pregnancy. In a nutshell, hCG helps the body build a safe and supportive nest for growing a baby. A woman who is not pregnant will likely have a baseline hCG level of less than
- [Google’s new AI will help researchers understand how our genes work](https://plminstitute.org/hot-topics/personalized-medicine/googles-new-ai-will-help-researchers-understand-how-our-genes-work/) - When scientists first sequenced the human genome in 2003, they revealed the full set of DNA instructions that make a person. But we still didn’t know what all those 3 billion genetic letters actually do. Now Google’s DeepMind division says it’s made a leap in trying to understand the code with AlphaGenome, an AI model
- [Evidence-Based Strategies to Reduce Patient No-Show Rates](https://plminstitute.org/hot-topics/health-fitness/evidence-based-strategies-to-reduce-patient-no-show-rates/) - Missed medical appointments cost the U.S. healthcare system more than $150 billion annually, and individual physicians about $200 for each used appointment time slot. Beyond dollars, no-shows disrupt continuity of care, delay diagnosis and treatment, and erode trust between patient and provider. The burden is particularly heavy on frontline staff and resource-constrained practices. Addressing this
- [How Does Glutathione Support Brain Health?](https://plminstitute.org/plmi-blog/how-does-glutathione-support-brain-health/) - Glutathione is a robust master antioxidant, abundant in the body and brain, with a growing body of findings illuminating its role in neuronal health (1). Glutathione is crucial for brain health due to its multifaceted roles, which include maintaining redox homeostasis, detoxification, and regulating neurotransmitters and appropriate immune responses. Its ability to reduce oxidative stress,
- [Dr. Bredesen vs. The New York Times: Whose Model Is More Predictive?](https://plminstitute.org/hot-topics/personalized-medicine/dr-bredesen-vs-the-new-york-times-whose-model-is-more-predictive/) - This week, The New York Times published yet another example of what has become a familiar genre: the wellness hit piece. This time, the target was Dr. Dale Bredesen, a neurologist who has spent the last decade challenging the status quo in cognitive decline care with a bold and hopeful question: Can Alzheimer’s be reversed?
- [Suffering with Long COVID? New Research Reveals Microclots May Hold the Key to Recovery](https://plminstitute.org/hot-topics/immune-health/suffering-with-long-covid-new-research-reveals-microclots-may-hold-the-key-to-recovery/) - As a functional medicine physician who has dedicated my career to uncovering the root causes of complex chronic illness, I've been closely following the emerging research on Long COVID. The persistent, debilitating symptoms that follow COVID-19 infection have puzzled many conventional medical practitioners, but new research is shedding light on a promising pathway to understanding
- [Creatine for Alzheimer's? Results of a New Study](https://plminstitute.org/hot-topics/epigenetics/creatine-for-alzheimers-results-of-a-new-study/) - Can Creatine Supplementation improve brain function in Alzheimer’s? Today we’re exploring the results of a just-published clinical trial showing this may be the case. For background on creatine and this study, several recent publications have discussed creatine’s value for brain health due to its potential to primarily boost brain metabolism and potentially, to improve the
- [GLP-1 Breakthroughs: Latest Research on Patient Outcomes and Safety](https://plminstitute.org/hot-topics/health-fitness/glp-1-breakthroughs-latest-research-on-patient-outcomes-and-safety/) - GLP-1 therapies are taking the medical world by storm, transforming treatment options for a range of chronic conditions. From diabetes to obesity, cardiovascular diseases, kidney health, and even neurodegenerative disorders, GLP-1 receptor agonists are reshaping how these diseases are managed. Originally developed for type 2 diabetes, these medications have shown remarkable promise in addressing other
- [Personalizing Perimenopause: Leveraging Genetic Insights from COMT, FUT2, and MTHFR for Tailored Nutrition and Medicine](https://plminstitute.org/plmi-blog/personalizing-perimenopause-leveraging-genetic-insights-from-comt-fut2-and-mthfr-for-tailored-nutrition-and-medicine/) - Perimenopause is a significant transitional phase marked by fluctuating estrogen and progesterone levels, resulting in alterations in metabolic, neuroendocrine, and immune pathways that influence health and well-being. These physiological shifts give rise to various symptoms, including mood changes, reduced libido, weight gain, hot flashes, and disrupted sleep. Emerging findings highlight the role of genetic variability
- [The Best Ways to Rewire Your Brain](https://plminstitute.org/hot-topics/epigenetics/the-best-ways-to-rewire-your-brain/) - By Austin Perlmutter, MD Until very recently, scientists believed the adult brain was a relatively static organ. The basic idea was that your brain grew and developed during childhood and then became relatively inflexible, until it slowly started to decline in function when we reached middle age. But this is no longer considered accurate. In
- [How Do Lifestyle Modifications Contribute to Hormonal Balance?](https://plminstitute.org/plmi-blog/how-do-lifestyle-modifications-contribute-to-hormonal-balance/) - Hormones are the body’s master messengers, regulating metabolism, mood, fertility, sleep, and more. Their balance is deeply influenced by daily choices—nutrition, movement, sleep, and stress—that feed back into the endocrine system. These lifestyle factors shape hormonal harmony through interconnected pathways, including metabolism, inflammation, immunity, detoxification, and the gut-brain axis (1). Nutrition Nutrition is a robust
- [The Hidden Impact of Microplastics on Your Gut (+ How to Protect Yourself)](https://plminstitute.org/hot-topics/microbiome/the-hidden-impact-of-microplastics-on-your-gut-how-to-protect-yourself/) - What if the plastic you throw away doesn’t just pollute the planet, but ends up inside your body, too? It might sound extreme, but that’s exactly what researchers are discovering. Tiny fragments of plastic – known as microplastics – are now turning up in everything from bottled water and table salt to human blood, gut
- [Fungal Influence: The Gut Mycobiome's Role in Health](https://plminstitute.org/plmi-blog/fungal-influence-the-gut-mycobiomes-role-in-health/) - The gut microbiome is a complex, multi-kingdom ecosystem composed of bacteria, viruses, archaea, and fungi. Emerging findings reveal the pivotal role of fungal communities, collectively referred to as the mycobiome, in modulating host physiology and immunity. While fungi comprise only 0.01%- 0.1% of the gut microbiome, their size, diverse metabolic functions, and immunomodulatory properties allow
- [DPO Symptoms: What to Expect From 1 to 12 Days Past Ovulation](https://plminstitute.org/hot-topics/health-fitness/dpo-symptoms-what-to-expect-from-1-to-12-days-past-ovulation/) - When you’re trying to conceive (TTC), waiting to take a pregnancy test can feel like the longest wait in the world. Even if you’re familiar with the intricacies of home pregnancy tests and when to take them, you might still be wondering why you have to wait two weeks for the most accurate results. Wonder
- [Key Health Impacts of Gut Dysbiosis](https://plminstitute.org/plmi-blog/key-health-impacts-of-gut-dysbiosis/) - The gut microbiome governs central homeostatic functions in the body, having profound effects on health. This diverse and complex ecosystem harbors densely populated communities of microbiota, viruses, fungi, and archaea—with each having integral roles in collectively modulating host physiology. Eubiosis describes harmonious balance among these vast interspecies of microorganisms, while dysbiosis refers to a disturbance
- [Gut Dysbiosis: Recent Research on Causes of Microbial Imbalance](https://plminstitute.org/plmi-blog/gut-dysbiosis-recent-research-on-causes-of-microbial-imbalance/) - The gut microbiome—a vast ecosystem of trillions of microorganisms with at least 1,000 diverse species—plays an integral role in governing overall health. This unique microbial community encodes for five million genes and is significant for modulating nearly every system in the body, integral for digestion, metabolism, immune, hormonal, and neurological health (1-3). Colonization of the
- [The Science of BPC-157](https://plminstitute.org/hot-topics/health-fitness/the-science-of-bpc-157/) - BPC-157 is a promising peptide that’s been studied for its potential to protect cells against harmful substances, promote tissue repair, and reduce inflammation. While it has shown promise in animal studies, its safety and efficacy in humans have remained uncertain due to a lack of robust clinical trials. However, a recent human clinical trial has
- [Napping: Good or Bad for Your Brain?](https://plminstitute.org/hot-topics/health-fitness/napping-good-or-bad-for-your-brain/) - by Austin Perlmutter MD Despite the vast amount of science to the contrary, good sleep is frequently ignored in the conversation about brain health optimization. If prioritizing sleep at night is seen as an afterthought, prioritizing a daytime nap can sometimes appear downright lazy or excessively indulgent. But what does the science tell us about
- [Want To Stay Sharp and Age Well? Why Infrared Saunas Are a Game-Changer](https://plminstitute.org/hot-topics/epigenetics/want-to-stay-sharp-and-age-well-why-infrared-saunas-are-a-game-changer/) - Aging is inevitable – but what if you could slow the process, stay sharp, and feel better for longer? While there’s no magic pill for eternal youth, science is proving that how we age is largely within our control. And one of the most exciting tools for supporting brain health, longevity, and overall vitality might
- [Why VO₂ Max Might Be the Most Important Number for Your Health (And How to Improve It)](https://plminstitute.org/hot-topics/health-fitness/why-vo₂-max-might-be-the-most-important-number-for-your-health-and-how-to-improve-it/) - A few years ago, only exercise scientists and endurance athletes talked about “VO₂ max.” (It’s pronounced “vee-oh-two-max,” in case you’re wondering.) But now, it’s a red-hot topic in longevity circles. That’s because it’s one of the strongest predictors of how long you’ll live and how well you’ll age. In fact, having a low VO₂ max is
- [Can Cognitive Decline Be Reversed Without an Environmental Lens?](https://plminstitute.org/hot-topics/health-fitness/can-cognitive-decline-be-reversed-without-an-environmental-lens/) - The Environmental Factors Driving Cognitive Decline Most doctors who specialize in cognitive health recognize the importance of metabolic inflammation, nutrient status, hormones, and vascular health. But without addressing environmental toxins, we’re missing a massive piece of the puzzle. Environmental medicine teaches us that the modern world is saturated with neurotoxic substances—plastics, pesticides, air pollutants, heavy
- [Natural Plant Compounds Show Promise for Immune Aging, New Research Reveals](https://plminstitute.org/hot-topics/epigenetics/natural-plant-compounds-show-promise-for-immune-aging-new-research-reveals/) - A new study published in Frontiers in Nutrition has revealed how compounds from an ancient grain might help address age-related immune decline. The research, titled "The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age: A Pilot Clinical Study," investigated how dietary components from Tartary buckwheat influence immune aging through epigenetic
- [Factors That Cause an Imbalance of the Gut Mycobiome](https://plminstitute.org/plmi-blog/factors-that-cause-an-imbalance-of-the-gut-mycobiome/) - The mycobiome, referring to the fungal biota or communities within the microbiome ecosystem, is a critical yet often underappreciated component of the human microbiome (1). Within the gut, fungi such as Candida species and food-derived fungi play an essential role in modulating physiological and pathophysiological processes that maintain overall host homeostasis. These fungi also influence
- [De-extinction scientists say these gene-edited ‘woolly mice’ are a step toward woolly mammoths](https://plminstitute.org/hot-topics/planetary-health/de-extinction-scientists-say-these-gene-edited-woolly-mice-are-a-step-toward-woolly-mammoths/) - By Jessica Hamzelou They’re small, fluffy, and kind of cute, but these mice represent a milestone in de-extinction efforts, according to their creators. The animals have undergone a series of genetic tweaks that give them features similar to those of woolly mammoths—and their creation may bring scientists a step closer to resurrecting the giant animals
- [Closing the Loop on Health Coaching](https://plminstitute.org/hot-topics/health-fitness/closing-the-loop-on-health-coaching/) - By James Maskell When we first started the Functional Forum back in 2014, one of our core missions was to popularize the clinician-coach dyad as the most efficient way to deliver functional medicine. My business partner, Gabriel Hoffman, was one of the first coaches in a functional medicine office when I met him in 2008.
- [When Blood Flow Slows Down: How Impaired Circulation Impacts Your Health (And What You Can Do About It)](https://plminstitute.org/hot-topics/health-fitness/when-blood-flow-slows-down-how-impaired-circulation-impacts-your-health-and-what-you-can-do-about-it/) - What comes to mind when you think of circulation? If you’re picturing just your heart or blood vessels, you're not wrong—but there’s so much more to the story. In this blog post, we’ll dive into the science of blood flow, explore common and often overlooked factors that impact circulation, and most importantly, show you what
- [Health Impacts of Epigenetics & Hormone Interactions](https://plminstitute.org/plmi-blog/health-impacts-of-epigenetics-hormone-interactions/) - The intricate dance between genes, environment, and hormones forms a crucial part of our understanding of health. The role of epigenetics (modifications above the genome that influence gene expression, without altering the underlying DNA sequence) is particularly notable. This interplay is pivotal for understanding the development of chronic health conditions, such as the ability of
- [Can Your Food Prevent Alzheimer's?](https://plminstitute.org/hot-topics/epigenetics/can-your-food-prevent-alzheimers/) - By Austin Perlmutter, MD Alzheimer's disease, a progressive neurodegenerative disorder, affects about 7 million people in the USA and many more worldwide, leading to cognitive decline, lower quality of life and even early death. While genetics and age are significant risk factors, recent research suggests that diet plays a crucial role in either exacerbating or
- [Does Fertility Tea Work? A Look at Ingredients & Science](https://plminstitute.org/hot-topics/health-fitness/does-fertility-tea-work-a-look-at-ingredients-science/) - Written by Kelly Berry | Medically reviewed by Banafsheh Kashani, MD, FACOG The internet is a wealth of information when it comes to boosting fertility or trying to conceive. If you’ve ever consulted Doctor Google, you’ll know that there’s no shortage of advice on how to get pregnant and are likely familiar with fertility tea
- [5 tips to eat healthy on a budget](https://plminstitute.org/hot-topics/health-fitness/5-tips-to-eat-healthy-on-a-budget/) - Nutritious foods don’t have to break the bank. Consider the following five tips for healthy eating on a budget. 1. Cook meals at home often One of the simplest ways to eat healthier on a budget is by cooking meals at home often. Frequently eating at home is associated with a greater intake of nutritious
- [Glutathione Benefits: Your Essential Antioxidant](https://plminstitute.org/hot-topics/health-fitness/glutathione-benefits-your-essential-antioxidant/) - Reviewed By: Dr. Patel | Author: Auro Team Glutathione is a potent antioxidant naturally produced by the body that is essential for detoxifying the body and maintaining overall health. Often called the “Master Antioxidant,” the benefits of Glutathione include its vital role in healthy aging, detoxification, and managing chronic conditions. Glutathione protects against oxidative stress
- [Microplastics and Cognitive Decline: The Hidden Root Cause Your Brain Health Program Must Address](https://plminstitute.org/hot-topics/health-fitness/microplastics-and-cognitive-decline-the-hidden-root-cause-your-brain-health-program-must-address/) - James Maskell If you’re a precision medicine or functional medicine doctor, you already know that cognitive decline isn’t just an inevitable part of aging—it’s a multifactorial, root-cause-driven condition that demands a systems biology approach. You’re tracking metabolic inflammation, optimizing nutrient and mitochondrial health, balancing hormones and trophic factors, and addressing gut-brain biotoxins. But one major
- [How the Medical Symptom Questionnaire Can Reveal Your “True” Health Score](https://plminstitute.org/hot-topics/health-fitness/how-the-medical-symptom-questionnaire-can-reveal-your-true-health-score-2/) - If I asked you how you’re feeling today, what would you say? Most people pause for a moment. Some might say, “I’m fine,” because they’re dealing with things they’d rather not mention (diarrhea will do that). Others might not even realize how much their symptoms—like bloating, joint pain, or fatigue—are weighing them down. Sometimes, folks
- [Is Your Body Overloaded with Toxins? Here’s The Best Way To Find Out](https://plminstitute.org/hot-topics/health-fitness/is-your-body-overloaded-with-toxins-heres-the-best-way-to-find-out-2/) - What if I told you that the toxins lurking in your everyday environment could be silently sabotaging your health, without you even knowing it? From the air you breathe to the products you use, these hidden toxins are more common than we think – and they’re not always easy to detect. So, how do you
- [Top 3 Foods That Age Your Brain and Body](https://plminstitute.org/hot-topics/epigenetics/top-3-foods-that-age-your-brain-and-body/) - By Austin Perlmutter, MD Aging is an inevitable part of life, but the rate at which we age—both physically and cognitively—can be influenced by various factors, including our dietary choices. Emerging research shows that certain foods that may accelerate the aging process at the level of our cells and contribute to worse brain health. This
- [Best Fertility Products to Buy in 2025: Top Solutions for Every Step of Your Journey](https://plminstitute.org/hot-topics/health-fitness/best-fertility-products-to-buy-in-2025-top-solutions-for-every-step-of-your-journey/) - Medically reviewed by Katerina Shkodzik, M.D., OB-GYN Written by Shelby Hale for Mira From the often unsolicited advice from friends and family to the never-ending TTC (trying to conceive) trends on social media, it can be hard to tell which products and strategies will actually help you get pregnant this year. At Mira, we want
- [Lifestyle Therapeutic Interventions to Improve Brain Health and Reverse Cognitive Decline](https://plminstitute.org/plmi-blog/lifestyle-therapeutic-interventions-to-improve-brain-health-and-reverse-cognitive-decline/) - Cognitive decline and dementia, particularly Alzheimer’s disease (AD), have become some of the most prevalent health conditions, with an estimated 6.9 million Americans 65 years of age and older living with AD (1). While genetics play a role in the etiology of these conditions, lifestyle factors also play a substantial role in how genes become
- [Is Your Body Overloaded with Toxins? Here’s The Best Way To Find Out](https://plminstitute.org/hot-topics/immune-health/is-your-body-overloaded-with-toxins-heres-the-best-way-to-find-out/) - What if I told you that the toxins lurking in your everyday environment could be silently sabotaging your health, without you even knowing it? From the air you breathe to the products you use, these hidden toxins are more common than we think – and they’re not always easy to detect. So, how do you
- [The aspirin mistake: 29 million take it daily, not realizing costs outweigh benefits](https://plminstitute.org/hot-topics/personalized-medicine/the-aspirin-mistake-29-million-take-it-daily-not-realizing-costs-outweigh-benefits/) - BY Lindsey Leake The decades-old medical advice that an aspirin a day keeps a heart attack away is outdated. Yet about half of U.S. adults are unaware that the consensus has changed for healthy older people not at increased risk of heart disease, a new survey says, a misconception that could be putting them in
- [Top Exercises For Brain Health](https://plminstitute.org/hot-topics/health-fitness/top-exercises-for-brain-health/) - By Austin Perlmutter, MD Brain health is critical to our cognitive function, our mood, general ability to interact with the world and so much more. While many factors contribute to overall brain wellness, exercise has been shown to be among the most effective interventions for preserving cognitive function, preventing neurodegenerative diseases, with additional research indicating
- [Emerging Treatments to Reverse Cognitive Decline of Early Dementia & Alzheimer’s](https://plminstitute.org/plmi-blog/emerging-treatments-to-reverse-cognitive-decline-of-early-dementia-alzheimers/) - Alzheimer’s disease is a prevalent and often devastating neurodegenerative disorder, currently affecting over six million individuals in the U.S., with research indicating it is now the third leading cause of mortality (1). An imbalance between amyloid β-protein (Aβ) production and clearance has been demonstrated to drive AD pathology, preceding its manifestation of pronounced cognitive symptoms
- [Can You Get Pregnant During Perimenopause?](https://plminstitute.org/hot-topics/health-fitness/can-you-get-pregnant-during-perimenopause/) - Medically reviewed by Katerina Shkodzik, M.D., OB-GYN | Written by Kelly Berry for Mira Perimenopause describes the natural decline in your fertility and transition to menopause. As you age, your fertility naturally declines and after age 40 it becomes increasingly unlikely that you will conceive. Once you’ve reached menopause, defined as the lack of a
- [How Many Steps the Average Person Walks Daily—Are You Keeping Up?](https://plminstitute.org/hot-topics/health-fitness/how-many-steps-the-average-person-walks-daily-are-you-keeping-up/) - By Sarah Jividen, RN Many believe that achieving 10,000 steps daily is the standard for good health, but studies show that the average American only walks about 4,000 to 5,000 steps daily. The ideal number of steps varies widely depending on age, job type, and how active someone is. Regular physical activity, such as walking,
- [Brain tissue may contain higher amounts of microplastics than other organs: Study](https://plminstitute.org/hot-topics/planetary-health/brain-tissue-may-contain-higher-amounts-of-microplastics-than-other-organs-study/) - The brain may contain higher -- and more significant -- amounts of microplastics than other organs in the body, according to a new study. Researchers from the University of New Mexico Health Sciences Center, Oklahoma State University, Duke University and La Universidad del Valle en Cali in Colombia analyzed brain, liver and kidney samples from
- [How the Medical Symptom Questionnaire Can Reveal Your “True” Health Score](https://plminstitute.org/hot-topics/health-fitness/how-the-medical-symptom-questionnaire-can-reveal-your-true-health-score/) - If I asked you how you’re feeling today, what would you say? Most people pause for a moment. Some might say, “I’m fine,” because they’re dealing with things they’d rather not mention (diarrhea will do that). Others might not even realize how much their symptoms—like bloating, joint pain, or fatigue—are weighing them down. Sometimes, folks
- [14 Low Estrogen Symptoms and Treatments](https://plminstitute.org/hot-topics/health-fitness/14-low-estrogen-symptoms-and-treatments/) - Medically reviewed by Katerina Shkodzik, M.D., OB-GYN Written by Shelby Hale for Mira From driving sexual development to regulating the menstrual cycle, there is no doubt that estrogen is a key player when it comes to your health and fertility. But what happens when estrogen levels dip below where they should be? How to deal
- [ISS National Lab research on cancer, neurodegenerative conditions returns to Earth](https://plminstitute.org/hot-topics/personalized-medicine/iss-national-lab-research-on-cancer-neurodegenerative-conditions-returns-to-earth/) - By Anthony Vecchione Research conducted on the International Space Station (ISS) may result in early cancer detection, advance treatments for neurodegenerative conditions and improve respiratory therapies. Space Station (ISS) on SpaceX’s 31st Commercial Resupply Services (CRS) was on a mission for NASA. SpaceX’s Dragon spacecraft contained close to 50 biotechnology, physical science and student research
- [New Advances in Menopausal Hormone Replacement Therapy](https://plminstitute.org/plmi-blog/new-advances-in-menopausal-hormone-replacement-therapy/) - Menopause marks a significant transition in a woman’s life and is often accompanied by a host of physical and emotional alterations, indicative of hormonal imbalance. As more than 50 million women enter menopause each year, the need for improved and efficient modalities to alleviate these symptoms is pivotal (1). While menopausal hormone replacement therapy (MHRT)
- [Could Diet Alter Your Personality?](https://plminstitute.org/uncategorized/could-diet-alter-your-personality/) - By Austin Perlmutter, MD When we think about personality, we often imagine something deeply ingrained—our tendencies toward extroversion or introversion, our levels of agreeableness or openness to new experiences. Personality seems fixed, an immutable aspect of our core character. But what if this foundation isn't as rigid as we think? What if something as seemingly
- [OpenAI has created an AI model for longevity science](https://plminstitute.org/hot-topics/personalized-medicine/openai-has-created-an-ai-model-for-longevity-science/) - By Antonio Regalado When you think of AI’s contributions to science, you probably think of AlphaFold, the Google DeepMind protein-folding program that earned its creator a Nobel Prize last year. Now OpenAI says it’s getting into the science game too—with a model for engineering proteins. The company says it has developed a language model that
- [How to Become an Integrative Medicine Doctor and Provide Whole Person Care](https://plminstitute.org/hot-topics/personalized-medicine/how-to-become-an-integrative-medicine-doctor-and-provide-whole-person-care/) - Written by Karolyn Gazella | Medically reviewed by Dr. Peter Woznik, ND, MSc Integrative medicine is a holistic approach to healthcare that blends conventional medical practices with complementary and alternative therapies, focusing on treating the whole person—body, mind, and spirit. (3) For those drawn to this personalized and patient-centered method of care, becoming an integrative
- [5 Ways Elderberry May Promote Overall Health and Wellness](https://plminstitute.org/hot-topics/epigenetics/5-ways-elderberry-may-promote-overall-health-and-wellness/) - Medically Reviewed by Dr. Ayesha Bryant MSPH, MD Elderberry (Sambucus nigra) has been used in traditional medicine for centuries, valued for its potential to support immune health, provide antioxidant benefits, and reduce inflammation. Today, elderberry continues to be a popular supplement taken by many to help maintain their wellness. But how exactly does elderberry contribute
- [PCO vs. PCOS: Understanding the Difference and What Each Means for Your Pregnancy](https://plminstitute.org/hot-topics/health-wellness/pco-vs-pcos-understanding-the-difference-and-what-each-means-for-your-pregnancy/) - Medically reviewed by Katerina Shkodzik, M.D., OB-GYN | Written by Boris Brut for Mira One of the hallmark symptoms of polycystic ovary syndrome (PCOS) is polycystic ovaries (PCO). What you might not know though is that not all women with PCO necessarily have PCOS. And not all women with PCOS necessarily have PCO. There is
- [Stem-cell therapies that work: 10 Breakthrough Technologies 2025](https://plminstitute.org/hot-topics/technology/stem-cell-therapies-that-work-10-breakthrough-technologies-2025/) - By Antonio Regalado A quarter-century ago, researchers isolated powerful stem cells from embryos created through in vitro fertilization. These cells, theoretically able to morph into any tissue in the human body, promised a medical revolution. Think: replacement parts for whatever ails you. But stem-cell science didn’t go smoothly. Not at first. Even though scientists soon
- [Beyond Estrogen Deficiency: The Role of Gut Microbiota in Postmenopausal Bone Loss](https://plminstitute.org/plmi-blog/beyond-estrogen-deficiency-the-role-of-gut-microbiota-in-postmenopausal-bone-loss/) - A recent 2024 study published in Frontiers in Endocrinology by Wang et al. provides compelling evidence of the profound and complex relationship between the gut microbiome and osteoporosis in postmenopausal women, underscoring novel and impactful insights for addressing this prevalent condition (1). Overview of Postmenopausal Osteoporosis Postmenopausal osteoporosis (PMOP) is a systemic, widespread bone disorder
- [Checklist: How to Get Pregnant in 2025](https://plminstitute.org/hot-topics/checklist-how-to-get-pregnant-in-2025/) - Medically reviewed by: Katerina Shkodzik, M.D., OB-GYN | Written by Mira Fertility for Mira You need a conception plan. We have it. We’ve crafted the ultimate roadmap to help you make your dream a reality. Our step-by-step guide is designed to give you the best shot at conceiving in 2025! What’s inside? Discover 4 practical steps to
- [How Blood Sugar Influences Brain Health](https://plminstitute.org/hot-topics/how-blood-sugar-influences-brain-health/) - By Austin Perlmutter, MD To think, act and feel in any way, your brain requires access to large amounts of consistent energy. For most of us, that energy comes in the form of blood sugar (glucose) which is transported into the brain and used by our brain cells. While it’s been well known that very
- [Fresh Starts and Fast Results: Your 10-Day Plan for the New Year](https://plminstitute.org/hot-topics/fresh-starts-and-fast-results-your-10-day-plan-for-the-new-year/) - Ever felt like New Year’s Day is your chance to become a new person? Some think it’s silly. Others find it exciting. But whether you love it or roll your eyes, there’s science behind that “new year, new you” feeling. According to University of Pennsylvania researchers, a psychological concept called the “fresh start effect” explains
- [Diet, Microbiome, and Bone Health: A Complex Interplay](https://plminstitute.org/plmi-blog/diet-microbiome-and-bone-health-a-complex-interplay/) - Nutrition provides the foundation for healthy bones through a number of interconnected mechanisms, and an emerging body of research highlights the microbiome specifically (1). Novel findings underscore the role nutrition has in modulating this vast ecosystem and thereby influencing bone metabolism and absorption of vital nutrients for bone health. The Intricacies of Bone Health Bone
- [How Impaired Immune Function and Dysregulated Metabolism Are Linked to Chronic Diseases](https://plminstitute.org/plmi-blog/how-impaired-immune-function-and-dysregulated-metabolism-are-linked-to-chronic-diseases/) - Chronic diseases are a leading cause of morbidity and mortality worldwide (1). At the core of these conditions lies a complex interplay between impaired immune function and dysregulated metabolism, both of which are critical drivers of disease onset and progression. Disruptions to appropriate immune responses and metabolic processes create a vicious cycle that accelerates the
- [Can Food Cause Immune Aging, Age-Related Diseases, Decreased Healthspan, and Shorter Lifespan?](https://plminstitute.org/plmi-blog/can-food-cause-immune-aging-age-related-diseases-decreased-healthspan-and-shorter-lifespan/) - A growing body of research shows the pivotal role nutrition plays in modulating immune function and promoting healthy aging (1-3). Mounting findings further highlight connections between aging of the immune system and diet, most notably the consumption of processed foods (4). This is an important connection, as immune system dysregulation is associated with the development
- [Glutathione 101: What It Is, Why It Matters, and How to Boost Your Levels](https://plminstitute.org/hot-topics/health-fitness/glutathione-101-what-it-is-why-it-matters-and-how-to-boost-your-levels/) - What if I told you there was a tiny but mighty molecule that could help combat chronic disease, boost your energy, detoxify harmful substances, and even support your immune system? Sounds too good to be true, right? But it’s real – and it’s called glutathione. In this blog post, we’re going to explore what glutathione
- [4 Key Strategies for Improving Patient Retention](https://plminstitute.org/hot-topics/technology/4-key-strategies-for-improving-patient-retention/) - Written By Heather Yoshimura AGNP-PC Patient retention forms the bedrock of sustainable healthcare practices. When patients consistently return for care, it signifies trust, satisfaction, and a solid patient-provider relationship. These factors contribute to better health outcomes and the financial stability and growth of medical practices. This article explores four key strategies to enhance patient retention.
- [What Coffee Does to Your Brain](https://plminstitute.org/hot-topics/epigenetics/what-coffee-does-to-your-brain/) - By Austin Perlmutter, MD Coffee is one of the most popular beverages consumed worldwide, prized for its taste and energizing effects. At the core of its stimulating properties is caffeine, the most consumed psychoactive compound on Earth. But what exactly does coffee do to your brain, and why do so many of us reach for
- [The Epigenetic Landscape of Aging: Unveiling Mechanisms and Interventions](https://plminstitute.org/plmi-blog/the-epigenetic-landscape-of-aging-unveiling-mechanisms-and-interventions/) - A recent 2024 review published in Cell Press explores the pivotal role epigenetic mechanisms have in governing the aging process, providing novel insights into the complex and intricate biological processes involved (1). Dysregulation in these critical regulatory mechanisms can impede cellular health and accelerate aging. Epigenetic dysregulation has emerged as a notable hallmark and driving
- [FDA clears application for CRISPR RNA-editing therapy developed using AI](https://plminstitute.org/hot-topics/personalized-medicine/fda-clears-application-for-crispr-rna-editing-therapy-developed-using-ai/) - By Jessica Hagen Global clinical-stage biotech company HuidaGene Therapeutics has received FDA clearance to move forward with its application for its investigational drug, a CRISPR/Cas13 RNA-editing therapy to treat neovascular age-related macular degeneration (nAMD), dubbed HG202, developed using machine learning and AI. The company used its HG-PRECISE platform (HuidaGene – Platform for Rational Engineering of
- [How exosomes could become more than just an “anti-aging” fad](https://plminstitute.org/hot-topics/personalized-medicine/how-exosomes-could-become-more-than-just-an-anti-aging-fad/) - By Jessica Hamzelou Over the past month or so, I’ve been working on a story about exosomes. You might have seen them advertised—they’re being touted as a hot new beauty treatment, a fountain of youth, and generally a cure-all therapy for a whole host of ailments. Any cell biologist, though, will tell you what exosomes
- [5 Top Trends in Medical Practice Management](https://plminstitute.org/hot-topics/health-fitness/5-top-trends-in-medical-practice-management/) - Written By Heather Yoshimura AGNP-PC Medical practices today face a whirlwind of changes. New technologies, shifting patient needs, and financial pressures are forcing practices to rethink their operations. Adapting to these changes is essential for both competitiveness and improving patient care. Virtual visits are becoming commonplace, and smart systems are reducing wait times, fundamentally altering
- [DNA Methylation Is a Biomarker that Can Predict Far More Than Aging](https://plminstitute.org/plmi-blog/dna-methylation-is-a-biomarker-that-can-predict-far-more-than-aging/) - Mounting research findings demonstrate the importance of DNA methylation as a robust indicator of biological health, influencing body and brain functions. Methylation, the addition of a methyl group (CH3) to DNA, modulates genetic expression and cellular health and occurs billions of times per second in every cell (1). Disruptions in this integral process result from
- [The Protein Leverage Hypothesis: Is This Why So Many People Are Overeating?](https://plminstitute.org/hot-topics/epigenetics/the-protein-leverage-hypothesis-is-this-why-so-many-people-are-overeating/) - Have you heard of the “protein leverage hypothesis”? This fascinating concept—proposed by two researchers at the University of Sydney—might be a big reason so many people eat far more today than they did a few decades ago.¹ It’s the idea that, above all else, you’re biologically programmed to seek a specific percentage of protein in
- [Genetic Leap, Lilly partner to expedite genetic medicine development with AI](https://plminstitute.org/hot-topics/technology/genetic-leap-lilly-partner-to-expedite-genetic-medicine-development-with-ai/) - By Anthony Vecchione The collaboration will leverage Genetic Leap's RNA-targeted AI platform to create genetic medicines against selected targets. AI and RNA genetic-medicine company Genetic Leap is teaming up with pharma giant Eli Lilly to develop genetic medicine therapeutics. According to the two companies, the partnership expands on a pilot program utilizing Genetic Leap's RNA-targeted AI
- [How to Optimize Your Brain Cells](https://plminstitute.org/hot-topics/epigenetics/how-to-optimize-your-brain-cells/) - By Austin Perlmutter MD To think, act, and feel any way, your brain must integrate an incredible amount of data in an astonishingly short amount of time. How this network functions influences your risk for mental health conditions, dementia, changes your behavior, and even affects how long you live. Most of our brain function occurs
- [Testosterone Levels and Mental Health: The Association Between Anxiety, Depression, and Hormones](https://plminstitute.org/hot-topics/personalized-medicine/testosterone-levels-and-mental-health-the-association-between-anxiety-depression-and-hormones/) - Written By Dr. Jillian Foglesong Stabile MD, FAAFP Hormone imbalances can significantly affect quality of life and health. Testosterone is no different. Testosterone imbalances in males and females can cause several symptoms and may worsen mental health. This article explores the association between anxiety, depression, and testosterone. Understanding Testosterone Testosterone is a steroid hormone responsible
- [hCG Levels Explained: Pregnancy, Testing, and What to Expect](https://plminstitute.org/hot-topics/health-fitness/hcg-levels-explained-pregnancy-testing-and-what-to-expect/) - Medically reviewed by Katerina Shkodzik, M.D., OB-GYN Written by Boris Brut for Mira HCG: What It Is and Why It Matters The Role of hCG in Pregnancy Human chorionic gonadotropin (hCG) is a crucial hormone during pregnancy. That holds especially true in its early stages. Its primary function is to stimulate the so-called corpus luteum,
- [Natural Ways to Treat Insulin Resistance](https://plminstitute.org/hot-topics/health-fitness/natural-ways-to-treat-insulin-resistance/) - Written by Karolyn Gazella & Rida Rehman, CNP Medically reviewed by Dr. Peter Woznik, ND, MSc Blood sugar (glucose) has an important chaperone in the body known as insulin. This hormone helps usher glucose into the cells where it can be used for energy. Without insulin, cells would not have access to this vital fuel
- [7 Health Benefits of Berberine Supplements](https://plminstitute.org/hot-topics/personalized-medicine/7-health-benefits-of-berberine-supplements/) - Berberine provide a wide range of health benefits and according to studies may positively influence insulin resistance, obesity, type 2 diabetes, and symptoms associated with metabolic syndrome such as high cholesterol and high blood pressure. (10)(11)(19) Berberine also demonstrates antifungal activity and has been used as a treatment for Candida and may influence certain hormones to
- [Case Study: Overcoming Fatigue, Low Mood, and Subclinical Hypothyroidism – A Functional Medicine Approach](https://plminstitute.org/hot-topics/personalized-medicine/case-study-overcoming-fatigue-low-mood-and-subclinical-hypothyroidism-a-functional-medicine-approach/) - Written By Dr. Michal Pearl Waldfogel ND In this case study, we explore Rachel's journey, a patient who initially presented with fatigue, low mood, and slow metabolism. Her case demonstrates the power of a functional medicine approach to uncover the underlying causes of her symptoms, which ranged from vitamin deficiencies to subclinical hypothyroidism. This approach
- [Understanding the Menstrual Cycle: Phases and Hormones Explained](https://plminstitute.org/hot-topics/health-fitness/understanding-the-menstrual-cycle-phases-and-hormones-explained/) - Written by Shelby Hale for Mira | Medically reviewed by Katerina Shkodzik, M.D., OB-GYN The human body continuously goes through cycles all the time. And here at Mira, one of our favorite cycles is… the menstrual cycle! In this article, we’ll cover everything you need to know about the stages of the menstrual cycle –
- [How Does Infrared Light Benefit The Human Body?](https://plminstitute.org/plmi-blog/how-does-infrared-light-benefit-the-human-body/) - Light plays a pivotal role in modulating biological processes at the cellular, organelle, and organ levels in the body. Responsible sunlight exposure is crucial for modulating circadian rhythm and a host of regulatory functions for systemic and mood health. The profound biological impacts of the sun help us to better understand the mechanisms underlying infrared
- [What Happens to Hormone Balance During an Infrared Sauna Session](https://plminstitute.org/hot-topics/health-fitness/what-happens-to-hormone-balance-during-an-infrared-sauna-session/) - WRITTEN BY: Colleen Travers Even if you’re only a little familiar with infrared sauna therapy, you might be aware that regular exposure to infrared heat comes with a slew of benefits. Aiding in muscle recovery, combating inflammation, and strengthening your immune system are a few. But one of the biggest benefits of using an infrared
- [4 Plant Nutrients That Change Your Brain](https://plminstitute.org/hot-topics/epigenetics/4-plant-nutrients-that-change-your-brain/) - By Austin Perlmutter, MD There’s no part of our body so tethered to our sense of self as our brains. From our brain wiring and structure comes our thoughts, our beliefs, our likes and dislikes and our actions. Even though we usually feel like the same “self” from day to day, the reality is that
- [Bartonella: The Sneaky Bacteria Behind Surprisingly Complex Symptoms](https://plminstitute.org/hot-topics/immune-health/bartonella-the-sneaky-bacteria-behind-surprisingly-complex-symptoms/) - What do sudden anxiety attacks, unexplained weight loss, and crippling fatigue all have in common? They can all be caused by Bartonella – a stealthy, shape-shifting bacteria that often flies under the radar. In this blog post, we’ll dive into what Bartonella is, its puzzling symptoms, how it evades diagnosis, and the most effective strategies
- [Roles of the Microbiome, Nutritional Deficiencies, Hormonal Imbalances, & the HPA Axis in Migraine Disorders](https://plminstitute.org/plmi-blog/roles-of-the-microbiome-nutritional-deficiencies-hormonal-imbalances-the-hpa-axis-in-migraine-disorders/) - Migraines have a complex and multifaceted pathophysiology, stemming from an interplay of genetic and environmental factors. The prevalence rates of migraines are shown to be between 2.6% and 21.7% of the population—affecting billions of individuals globally—with higher rates reported in women (1). A growing body of research demonstrates the influence that systemic imbalances, nutrition, and
- [How Can Hormone Tracking Improve Women’s Health?](https://plminstitute.org/plmi-blog/how-can-hormone-tracking-improve-womens-health/) - Hormones play integral roles in modulating all facets of health, existing in a delicate and dynamic balance. When this equilibrium is disrupted, it can have a number of widespread effects, compromising systemic homeostasis, well-being, and quality of life. Hormone levels continuously shift in response to biochemical processes in the body, cyclic patterns, lifestyle, genetics, and
- [Feeling Bloated and Anxious? Discover the Connection to Leaky Gut, SIBO, and SIFO.](https://plminstitute.org/hot-topics/microbiome/feeling-bloated-and-anxious-discover-the-connection-to-leaky-gut-sibo-and-sifo/) - Do you ever feel like you're lugging around a "food baby"? No matter what you eat, you’re constantly bloated. And sometimes your stomach hurts too. Beyond that, you experience brain fog. You can’t concentrate. You're anxious, irritable and perpetually exhausted. And now, mysterious skin issues? Random itchy spots appearing on your body, rashes, or even
- [11 Signs of Estrogen Dominance (+ Causes and Risks)](https://plminstitute.org/hot-topics/health-fitness/11-signs-of-estrogen-dominance-causes-and-risks/) - Medically reviewed by Katerina Shkodzik, M.D., OB-GYN | Written by Shelby Hale for Mira If you have ever experienced heavy periods, breast tenderness, or water retention during your premenstrual phase, you are already familiar with the effects that estrogen can have on your body. But when estrogen is chronically high, some of these symptoms can
- [How To Create Your Own Personal Hydration Plan](https://plminstitute.org/hot-topics/health-fitness/how-to-create-your-own-personal-hydration-plan/) - In your journey to take care of yourself and feel better, you’ve likely been hearing about the importance of drinking enough water during the day. This may lead you to wonder how much water you should drink before and after you sauna. Knowing your sweat rate for an activity helps you be more accurately educated
- [Why You Feel Dizzy After Eating: Expert Insights and Remedies](https://plminstitute.org/hot-topics/health-fitness/why-you-feel-dizzy-after-eating-expert-insights-and-remedies/) - Written By Erin Coleman RD While it’s not ideal to feel dizzy after eating, this symptom is common among older adults. In fact, about 40% of people aged 65-86 have postprandial hypotension, a condition that causes a drop in blood pressure and dizziness after eating food. It’s vital to understand the cause of this phenomenon
- [Is a Microbiome Test the Right Tool for Listening to the Gut?](https://plminstitute.org/hot-topics/microbiome/is-a-microbiome-test-the-right-tool-for-listening-to-the-gut-2/) - The human microbiome, more specifically the gut microbiome and the microbes living throughout the gastrointestinal tract, have become hot topics throughout the scientific community. Research currently being conducted worldwide indicates that the balance of these gut microbes may have a powerful impact on both short-term and long-term health. Through widely available and disseminated research and
- [Hormonal Dance: The Rhythms of the Female Cycle and the Far-reaching Impacts of Imbalances](https://plminstitute.org/plmi-blog/hormonal-dance-the-rhythms-of-the-female-cycle-and-the-far-reaching-impacts-of-imbalances/) - The menstrual cycle is a complex interaction of hormonal signals involving estradiol, progesterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH). Hormonal balance is crucial for overall well-being, affecting everything from energy levels to fertility, vitality, and metabolic, immune, bone, and emotional health. Imbalances, however, can disrupt these essential processes. Understanding the impacts of imbalances and
- [Fighting Fibromyalgia: The Surprising Benefits Of A Gluten-Free Diet](https://plminstitute.org/hot-topics/health-fitness/fighting-fibromyalgia-the-surprising-benefits-of-a-gluten-free-diet/) - Have you ever felt like your body is waging a war against you – with every muscle aching, fatigue pulling you down, and a constant fog clouding your mind? For millions of people living with a complex condition known as fibromyalgia, this is their daily reality. This chronic condition, often misunderstood and misdiagnosed, turns even
- [The Science of Preventing Dementia](https://plminstitute.org/hot-topics/health-fitness/the-science-of-preventing-dementia/) - What Causes Dementia, and 6 Powerful Tools to Apply Today By Austin Perlmutter, MD Dementia is a word that strikes fear into the hearts of many. The thought of losing cognitive function, of forgetting loved ones and cherished memories is simply terrifying. Dementia isn’t just a general health issue; it’s a deeply personal one. I’ve
- [How Hormones Affect Our Immune System](https://plminstitute.org/hot-topics/immune-health/how-hormones-affect-our-immune-system/) - Written by Samaria Mills for Mira The sex hormones estrogen, testosterone, and progesterone are known to play a role in the way that our bodies respond to sex and fertility. However, these same hormones play a much bigger role in the way our bodies function. Our sex hormones play in our bodies is related to
- [Signs and Symptoms of Oral Dysbiosis & Low Nitric Oxide Levels](https://plminstitute.org/plmi-blog/signs-and-symptoms-of-oral-dysbiosis-low-nitric-oxide-levels/) - A growing body of evidence reveals that dysbiosis of the oral microbiome impedes systemic health, in part by reducing nitric oxide (NO) production. NO, a key gaseous signaling molecule, has been well demonstrated to be involved in a host of regulatory physiological functions in the body (1). Beneficial microbiota in both the oral cavity and
- [Is a Microbiome Test the Right Tool for Listening to the Gut?](https://plminstitute.org/hot-topics/microbiome/is-a-microbiome-test-the-right-tool-for-listening-to-the-gut/) - Written by Chloe Girvan The human microbiome, more specifically the gut microbiome and the microbes living throughout the gastrointestinal tract, have become hot topics throughout the scientific community. Research currently being conducted worldwide indicates that the balance of these gut microbes may have a powerful impact on both short-term and long-term health. Through widely available
- [Can a Non-Physician Own a Medical Practice?](https://plminstitute.org/hot-topics/personalized-medicine/can-a-non-physician-own-a-medical-practice/) - By Erin Coleman RD There is a growing interest in healthcare investments and expanding opportunities for non-physicians to enter the healthcare and wellness industries as practice owners. These trends are changing the landscape of healthcare ownership, creating new possibilities for investors and entrepreneurs who aren't medically trained or legally able to provide healthcare. The article
- [5 Tips for Sustainable Growth in Your Functional Medicine Practice](https://plminstitute.org/hot-topics/personalized-medicine/5-tips-for-sustainable-growth-in-your-functional-medicine-practice/) - By Erin Coleman RD Sustainable growth is vital in ensuring the long-term success of functional medicine practices. Maintaining exceptional, top-quality care during growth periods is critical to ensuring patient satisfaction and future expansion. This article explores five implementation and sustainable growth strategies that help functional medicine practices maintain exemplary services, flourish long-term, and grow. Full
- [Oral Microbiome, Gut Health, Nitric Oxide, and Chronic Disease - How are they linked?](https://plminstitute.org/plmi-blog/oral-microbiome-gut-health-nitric-oxide-and-chronic-disease-how-are-they-linked/) - As of 2024, chronic disease is shown to affect at least 129 million individuals in the US (1). A growing body of research demonstrates the connection between chronic disease and nitric oxide (NO) production, a critical molecule that governs an array of biological processes integral to systemic and overall health. The state of the oral
- [Tandem Diabetes Care, Dexcom announce t:slim X2 Insulin Pump availability in Canada](https://plminstitute.org/hot-topics/personalized-medicine/tandem-diabetes-care-dexcom-announce-tslim-x2-insulin-pump-availability-in-canada/) - By Nathan Eddy The Tandem Diabetes Care t:slim X2 Insulin Pump, which is compatible with glucose monitoring specialist Dexcom's G7 and G6 continuous glucose monitoring (CGM) systems, has been cleared for sale by Health Canada, the department within the government of Canada responsible for national health policy. t:slim, which holds up to 300 units of
- [Biological Age vs. Chronological Age—Why It Matters  ](https://plminstitute.org/hot-topics/epigenetics/biological-age-vs-chronological-age-why-it-matters/) - We all want the same thing: the chance to live a full, rich, active life for as long as we can. Unfortunately, time only moves in one direction. Traditionally, most people have thought of the aging process as equally fixed. But longevity researchers have developed an exciting new framework for thinking about aging that offers
- [Anovulatory Cycle: How to Recognize, Prevent, and Treat It](https://plminstitute.org/hot-topics/health-fitness/anovulatory-cycle-how-to-recognize-prevent-and-treat-it/) - Written by Sylvia Kang for Mira | Medically reviewed by Katerina Shkodzik, M.D., OB-GYN If you’re planning a pregnancy, you’ll already know that a key milestone in the menstrual cycle is ovulation. But what happens if ovulation doesn’t occur? This condition is called anovulation, and it occurs when the ovaries do not release an egg
- [Everything You Need To Know About The Low-FODMAP Diet](https://plminstitute.org/hot-topics/health-fitness/everything-you-need-to-know-about-the-low-fodmap-diet/) - Researchers have investigated the link between environmental factors and gastrointestinal symptoms for decades. In 2004, a group of scientists at Monash University was the first to use the term “FODMAPs” to describe a specific group of carbohydrates that includes Fermentable Oligosaccharides, Disaccharides, Monosaccharides, And Polyols. These researchers proposed the “FODMAP hypothesis”, which associated FODMAP intake
- [CoQ10 and Statins: Why Take Them Together](https://plminstitute.org/hot-topics/health-fitness/coq10-and-statins-why-take-them-together/) - By Dr. Kelley Garrison ND Coenzyme Q10 (CoQ10) is crucial for energy production and cellular health, particularly in high-energy organs and muscle tissue. It is also a powerful antioxidant. Statins are used to lower cholesterol and reduce cardiovascular risk, but they can deplete CoQ10 levels, potentially causing muscle pain and weakness. Taking CoQ10 supplements alongside
- [7 Symptoms of Low Testosterone in Men](https://plminstitute.org/hot-topics/health-fitness/7-symptoms-of-low-testosterone-in-men/) - Low testosterone significantly impacts many aspects of men's health. This hormone is essential not just for sexual function but also influences muscle mass, mood regulation, and overall energy levels. It's important to identify related symptoms, especially considering that about 39% of men aged 45 and older in the United States experience this condition, and the
- [Biotech companies are trying to make milk without cows](https://plminstitute.org/hot-topics/technology/biotech-companies-are-trying-to-make-milk-without-cows/) - By Antonio Regalado The outbreak of avian influenza on US dairy farms has started to make milk seem a lot less wholesome. Milk that’s raw, or unpasteurized, can actually infect mice that drink it, and a few dairy workers have already caught the bug. The FDA says that commercial milk is safe because it is
- [Gut Health and Sleep: How Are They Connected?](https://plminstitute.org/hot-topics/microbiome/gut-health-and-sleep-how-are-they-connected-2/) - By Molly Knudsen, MS, RDN According to the Centers for Disease Control and Prevention, adults need seven or more hours of sleep each night to support overall health.1 Unfortunately, a staggering 35.2% of adults fall short of this goal, experiencing what is known as short sleep duration.1 This lack of sleep can have a significant
- [Hormone Imbalance in Women: 17 Signs, Causes & Treatments](https://plminstitute.org/hot-topics/health-fitness/hormone-imbalance-in-women-17-signs-causes-treatments/) - Medically reviewed by Katerina Shkodzik, M.D., OB-GYN Often referred to as the body’s “chemical messengers”, hormones are a powerful force behind many bodily functions and humans have over 50 different hormones that influence our metabolism, mood, reproductive health, development, and so much more! But what happens if these hormones are not in balance? And how
- [How Do Epigenetic Mechanisms & Nutrition Impact Male & Female Fertility?](https://plminstitute.org/plmi-blog/how-do-epigenetic-mechanisms-nutrition-impact-male-female-fertility/) - Identifying variations in genetic and biological processes can pave the way for improved and individualized fertility outcomes. Epigenetics describes how these mechanisms are shaped by nutrition, lifestyle, and environmental factors, which play pivotal roles in fertility. A growing body of evidence suggests that nutrition across the entire lifespan exerts a powerful influence in improving processes
- [Benefits of Fruit And Vegetable Supplements](https://plminstitute.org/hot-topics/health-wellness/benefits-of-fruit-and-vegetable-supplements/) - Fruit and vegetables provide valuable nutrients for overall health and well-being, as well as reduced risk of disease. However, a 2015 analysis by the Centers for Disease Control and Prevention (CDC) found that only 12% and 9% of adults ate the recommended amounts of fruits and vegetables, respectively. (2) Keep reading to learn about how
- [How Genetic and Gut Health Testing Can Support Your Patients' Longevity](https://plminstitute.org/hot-topics/microbiome/how-genetic-and-gut-health-testing-can-support-your-patients-longevity/) - A patient’s gut might not be the most obvious place to look for the origins of mental health disorders, immune dysfunction, or chronic inflammation. More and more research, however, is pointing to the fact that gut health can have a profound influence over a person’s mental and physical health. So, how can you get an
- [Mira Launches Groundbreaking Hormone Health Clinic for Fertility](https://plminstitute.org/hot-topics/health-fitness/mira-launches-groundbreaking-hormone-health-clinic-for-fertility/) - Written by Mira Fertility for Mira For couples struggling with infertility, the journey to get pregnant can be overwhelming and emotionally draining. The lack of personalized support and guidance often leaves them with more questions than answers. Mira Fertility, the America’s fastest-growing femtech company according to Inc.5000, is revolutionizing this experience by launching its innovative
- [Improving Fertility Through Modifiable Lifestyle Factors & Nutrigenomics](https://plminstitute.org/plmi-blog/improving-fertility-through-modifiable-lifestyle-factors-nutrigenomics/) - While a number of factors outside of our control exert influence on fertility, including age and genetics, a multitude of factors in our control also exert profound influence, including nutrition, lifestyle, and environment. A functional and integrative approach to fertility recognizes the various multidimensional influences that can either optimize or impede reproductive health in conjunction
- [Precision Medicine in Cardiology: The Role of Genomics and AI to optimize Coronary Artery Disease Treatment and Prevention](https://plminstitute.org/plmi-blog/precision-medicine-in-cardiology-the-role-of-genomics-and-ai-to-optimize-coronary-artery-disease-treatment-and-prevention/) - – Dr. Peter Kozlowski, MD The World Health Organization (WHO) estimates that over 75% of premature cardiovascular disease (CVD) (1) is preventable… A shocking study (2) published on June 4th, 2024 said (2); “At least 6 in 10 U.S. adults (61%), more than 184 million people, are expected to have some type of CVD within the
- [Your guide to the gut-immune connection](https://plminstitute.org/uncategorized/your-guide-to-the-gut-immune-connection/) - What is "gut health"? These days, “gut health” is a popular topic in health discussions. But what does that actually mean? While there are many ways people define “gut health,” the term really refers to the function of the gastrointestinal (GI) system which runs from our mouth to our large intestine. It also incorporates the
- [What’s next for bird flu vaccines](https://plminstitute.org/hot-topics/technology/whats-next-for-bird-flu-vaccines/) - By Cassandra Willyard Here in the US, bird flu has now infected cows in nine states, millions of chickens, and—as of last week—a second dairy worker. There’s no indication that the virus has acquired the mutations it would need to jump between humans, but the possibility of another pandemic has health officials on high alert.
- [Trouble Sleeping? – Reasons You May be Waking Up at Night](https://plminstitute.org/hot-topics/health-fitness/trouble-sleeping-reasons-you-may-be-waking-up-at-night/) - You may be surprised to hear that waking up in the middle of the night is common. One US study found 35.5% of people wake up in the middle of the night on three or more nights per week.1 Understanding why this sleep disturbance occurs in so many people is not easy to pinpoint, but
- [Is It Safe to Buy Supplements on Amazon? Counterfeit Concerns](https://plminstitute.org/hot-topics/technology/is-it-safe-to-buy-supplements-on-amazon-counterfeit-concerns/) - The dietary supplement industry was already on an upward trend but has grown exponentially in recent years. In April 2020 in the United States, the supplement market had grown 44% since the previous year. (7) With this growth came an increase in online marketplaces selling supplements, with Amazon being the most popular and convenient option.
- [6 Supplements to Boost Testosterone Levels](https://plminstitute.org/hot-topics/epigenetics/6-supplements-to-boost-testosterone-levels/) - by Heather Yoshimura AGNP-PC Hormone replacement therapy isn't the only option for those looking to boost their testosterone levels as they age. Many are turning to testosterone supplements, which have gained popularity as a natural method to enhance hormone levels. These supplements cater to a range of needs, from addressing age-related declines in testosterone to
- [What Foods Carry a Risk of Parasite Infection?](https://plminstitute.org/hot-topics/health-fitness/what-foods-carry-a-risk-of-parasite-infection/) - by Erin Coleman RD Foodborne parasitic infections are common, affecting at least 12 million people in the United States and more than 2 billion people worldwide. However, such infections often go undiagnosed due to poor awareness of these common microorganisms. Foodborne parasitic infections often stem from protozoa or intestinal worms getting inside the digestive tract
- [Meta-inflammation in Obesity & Its Therapeutic Targeting](https://plminstitute.org/plmi-blog/meta-inflammation-in-obesity-its-therapeutic-targeting/) - Obesity is an increasingly prevalent issue today, affecting more than one billion individuals worldwide; it has more than doubled since 1990 among adults and quadrupled among children and adolescents (1). “Meta-inflammation in obesity & its therapeutic targeting,” published in Science Translational Medicine, addresses a number of complex interactions in obesity, with a focus on underlying
- [Cortisol & PCOS: Understanding the Link (W/ Tips for Managing)](https://plminstitute.org/hot-topics/personalized-medicine/cortisol-pcos-understanding-the-link-w-tips-for-managing/) - by Dr. Rachel Magerman ND Polycystic Ovary Syndrome (PCOS) affects millions of women worldwide, impacting fertility, metabolic health, and emotional well-being. With symptoms ranging from irregular menstrual cycles to heightened risks of diabetes and cancer, PCOS presents significant challenges. Full Article
- [Stress Hormone Balance: Navigating the Path to Well-Being](https://plminstitute.org/hot-topics/health-fitness/stress-hormone-balance-navigating-the-path-to-well-being/) - by Dr. Jennifer L. Weinberg MD, MPH, MBE When faced with a real or perceived threat or stressor, your body releases cortisol and adrenaline as critical mediators of the stress response. These stress hormones are key actors helping to mobilize resources, sharpen focus, and prepare for action. In addition to helping you cope with stress,
- [AI in Medicine: Challenges and Benefits of AI in Healthcare](https://plminstitute.org/hot-topics/technology/ai-in-medicine-challenges-and-benefits-of-ai-in-healthcare/) - As artificial intelligence (AI) grows in capability and popularity, its potential to revolutionize the healthcare industry becomes evident. However, as with any new technology, there are many ethical considerations to keep in mind. Keep reading to learn about the role of AI technology in health and medicine. The benefits of AI in healthcare From improving
- [Impact of Toxins on Hormones: Can Detoxification Strategies Balance Hormones?](https://plminstitute.org/plmi-blog/impact-of-toxins-on-hormones-can-detoxification-strategies-balance-hormones/) - The prevalence of toxins in our environment has increased exponentially within the last several decades. 85,000 synthetic chemicals have been identified in the environment, with at least 1,000 having endocrine disrupting properties (1). These may include persistent organic pollutants (POPs), metals, lead, mercury, bisphenol A (BPA), phthalates, pesticides, perfluorochemicals (PFCs), and polychlorinated biphenyls (PCBs), in
- [A Root Cause Medicine Approach to Root Canals](https://plminstitute.org/hot-topics/health-fitness/a-root-cause-medicine-approach-to-root-canals/) - by Dr. Rachel Magerman ND Root canal treatments have become a common solution in dentistry for addressing tooth decay and infection. As one of the primary methods for preserving natural teeth, root canals play a significant role in maintaining oral health. However, there is growing interest in exploring alternative perspectives on root canal therapy. In
- [Oura smart ring company extends heart health capabilities](https://plminstitute.org/hot-topics/health-fitness/oura-smart-ring-company-extends-heart-health-capabilities/) - By Nathan Eddy Finland-based Oura, the maker of its namesake health tracking ring, announced it added two heart health monitoring features to its Oura Ring wearable device, Cardiovascular Age (CVA) and Cardio Capacity, which will be available later this month on Oura Ring Gen3 devices for both Android and iOS. The CVA feature uses data
- [Navigating Iron Needs: Understanding Iron Supplementation for Women](https://plminstitute.org/hot-topics/personalized-medicine/navigating-iron-needs-understanding-iron-supplementation-for-women/) - by Yekta Dowlati, PhD Iron is a vital nutrient that serves as a fundamental component of heme and various coenzymes, playing critical roles in essential biochemical pathways. It is integral to the transport of oxygen via hemoglobin, supports mitochondrial oxidative phosphorylation for energy production, and is necessary for the synthesis of DNA.1 In female individuals,
- [How Does Chronic Stress Weaken the Endocrine System?](https://plminstitute.org/plmi-blog/how-does-chronic-stress-weaken-the-endocrine-system/) - Modern day life is full of demanding stressors, with 77 % of Americans reporting that they regularly experience physical symptoms of stress and 73% experiencing psychological symptoms (1). While the body is equipped to handle small amounts of stress, prolonged and excessive amounts can have compromising effects. Chronic stress induces a number of systemic changes
- [How Does Aging Impact the Endocrine System?](https://plminstitute.org/plmi-blog/how-does-aging-impact-the-endocrine-system/) - Aging is a biological process in which there is a progressive loss of physiological functions in the body, from cells to tissues and organs. Aging has significant effects on countless body systems. Notably, aging is associated with various alterations in the endocrine system (1). As this system has a bidirectional effect on the regulation of
- [The effort to make a breakthrough cancer therapy cheaper](https://plminstitute.org/hot-topics/immune-health/the-effort-to-make-a-breakthrough-cancer-therapy-cheaper/) - CAR-T therapies, created by engineering a patient’s own cells to fight cancer, are typically reserved for people who have exhausted other treatment options. But last week, the FDA approved Carvykti, a CAR-T product for multiple myeloma, as a second-line therapy. That means people are eligible to receive Carvykti after their first relapse. Full Article
- [Is CBD Safe and Effective? What You Need to Know When Considering CBD](https://plminstitute.org/hot-topics/health-fitness/is-cbd-safe-and-effective-what-you-need-to-know-when-considering-cbd/) - Cannabis is an extraordinary plant with many practical purposes. It can be spun into rope or clothing. Pain-relieving medicinal oil can be pressed from it. Nutritious protein powders can be derived from the seeds. Processed correctly, it can even become biofuel for cars! Yet, what makes cannabis genuinely unique is the fact that it has
- [The Pros and Cons of Food Sensitivity Tests](https://plminstitute.org/hot-topics/immune-health/the-pros-and-cons-of-food-sensitivity-tests/) - Do you experience frequent abdominal issues, brain fog, sinus problems, or even mysterious skin rashes? It could be something you ate! Food sensitivities have become a hot topic in the world of integrative health, particularly since they appear to be on the rise. (5) According to some estimates, food sensitivities impact up to 20% of
- [5 Quick and Easy Anti-Inflammatory Breakfast Ideas for Busy Mornings](https://plminstitute.org/hot-topics/health-fitness/5-quick-and-easy-anti-inflammatory-breakfast-ideas-for-busy-mornings/) - by Heather Yoshimura AGNP-PC Sometimes healthy eating can feel like a daunting task. However, the good news is that there are numerous quick and healthy recipes designed to fit into even the busiest of schedules. We’re about to explore five easy-to-prepare, and anti-inflammatory breakfast ideas that will help you get out of the door quickly
- [How Tiny Health Is Bringing Microbiome Testing To Infants](https://plminstitute.org/hot-topics/microbiome/how-tiny-health-is-bringing-microbiome-testing-to-infants/) - by Sophia Lee Your gut microbiome is one of the most critical determinants of health — influencing everything from your mental well-being to your immune function to your fitness levels. More people are recognizing this, which is why it’s a huge area of focus for functional practitioners. We’re also seeing an influx in startups, such
- [Luteinizing Hormone - Here’s All You Need to Know](https://plminstitute.org/hot-topics/personalized-medicine/luteinizing-hormone-heres-all-you-need-to-know/) - by Dr. Rachel Magerman ND What Is Luteinizing Hormone? Luteinizing hormone (LH) is secreted along with follicle-stimulating hormone (FSH) by gonadotropin cells in the pituitary. LH plays a critical role in the development of the reproductive system in males and females. LH works in tandem with other sex hormones to regulate the menstrual cycle and
- [The Connection Between Endocrine Function & Metabolic Disorders/Obesity](https://plminstitute.org/plmi-blog/the-connection-between-endocrine-function-metabolic-disorders-obesity/) - The prevalence of obesity and metabolic disorders has dramatically increased in recent years, making these conditions public health concerns (1). Interestingly, the endocrine system governs key processes in the brain and body, playing a robust role in metabolic health. Multifactorial Lens & Etiology of Metabolic Disorders Metabolism refers to the synthesis, utilization, and storage of
- [Vitamin C Health Benefits and Best Sources](https://plminstitute.org/hot-topics/health-fitness/vitamin-c-health-benefits-and-best-sources-2/) - Vitamin C is commonly known for its role in supporting the immune system, particularly for preventing infections such as the common cold. But did you know that the health effects of vitamin C range from collagen formation to prevention of ocular diseases? Continue reading to learn about vitamin C, including its functions in the body,
- [This startup wants to fight growing global dengue outbreaks with drones](https://plminstitute.org/hot-topics/technology/this-startup-wants-to-fight-growing-global-dengue-outbreaks-with-drones/) - By Jill Langlois The world is grappling with dengue epidemics, with 100 to 400 million cases worldwide every year, an eightfold increase since 20 years ago, according to the World Health Organization. Much of this is driven by the warming climate, which allows mosquitos to thrive in more areas. A startup in São Paulo, Brazil,
- [Gut Health and Sleep: How Are They Connected?](https://plminstitute.org/hot-topics/epigenetics/gut-health-and-sleep-how-are-they-connected/) - By Molly Knudsen, MS, RDN According to the Centers for Disease Control and Prevention, adults need seven or more hours of sleep each night to support overall health.1 Unfortunately, a staggering 35.2% of adults fall short of this goal, experiencing what is known as short sleep duration.1 This lack of sleep can have a significant
- [Understanding the Impact of Sweetened Beverages on Heart Rhythm: Insights from a Recent Study](https://plminstitute.org/hot-topics/epigenetics/understanding-the-impact-of-sweetened-beverages-on-heart-rhythm-insights-from-a-recent-study/) - Medically reviewed by Dr. Amitha Kalaichandran MD MHS In our daily lives, we often find ourselves standing in front of the beverage aisle, making choices that seem simple yet have the power to impact our health in ways we might not fully realize. From the vibrant cans of sugar-sweetened beverages (SSBs) to the sleek bottles
- [Keys Ways the Exposome Impacts Endocrine Function](https://plminstitute.org/plmi-blog/keys-ways-the-exposome-impacts-endocrine-function/) - Beginning in utero and throughout the course of our lives, we are exposed to an extensive amount of environmental influences and insults that can alter integral regulatory processes in the body, and even the expression of our genes (1). According to the World Health Organization (WHO), environmental toxins that impede systemic health include heavy metals
- [Support Healthy Weight and Blood Sugar Levels With Evidence-based Ingredients](https://plminstitute.org/hot-topics/epigenetics/support-healthy-weight-and-blood-sugar-levels-with-evidence-based-ingredients-3/) - The prevalence of obesity and metabolic conditions, including prediabetes and diabetes, presents a significant public health concern. The Centers for Disease Control and Prevention (CDC) estimates that as of 2020 nearly 42% of the American population has obesity. (5) Meanwhile, it’s estimated that 11.6% of the U.S. population has diabetes and 38% has prediabetes. (6)
- [Can Probiotics Help Reduce Stress?](https://plminstitute.org/hot-topics/epigenetics/can-probiotics-help-reduce-stress/) - Probiotic Strain L. paracasei Lpc-37® Reduced Stress in Healthy Adults Scientists have been searching for “psychobiotics,” probiotics that can modify the gut-brain axis,1 and now a recent publication using a robust clinical trial design demonstrated a probiotic strain that improved the stress response. Previous preclinical studies demonstrated that Lacticaseibacillus paracasei Lpc-37 (Lpc-37), formerly known as Lactobacillus paracasei Lpc-37
- [The Digestive Supersystem: Nervous, Endocrine, Immune, and Hepatobiliary System Interactions](https://plminstitute.org/plmi-blog/the-digestive-supersystem-nervous-endocrine-immune-and-hepatobiliary-system-interactions/) - Understanding the intricate interactions between various physiological systems is paramount for comprehending the root cause of health issues and devising effective treatment strategies. Much like a highway system engineered to allow multi-directional travel carrying goods and services, information, and waste between suburban neighborhoods and a central city hub, the digestive system relies on interactions with
- [How Are GI Disorders Related to the Microbiome?](https://plminstitute.org/plmi-blog/how-are-gi-disorders-related-to-the-microbiome/) - The gut microbiome harbors an estimated ten trillion to quintillion diverse microorganisms (1). The microbiome refers to the set of genes that are expressed by these microorganisms — including bacteria, fungi, viruses, parasites, and archaea—collectively referred to as microbiota (2). Composition of the microbiome has an integral role in regulating homeostasis in the body. A
- [30 Common Fish Oil Tested for Low Oxidation](https://plminstitute.org/hot-topics/health-fitness/30-common-fish-oil-tested-for-low-oxidation/) - Fish oil is susceptible to oxidation due to its highly unsaturated structure. Once fish oil starts to oxidize, a notable fishy smell and taste emerges. It’s this smell and taste that often leads patients to discontinue the use of fish oils. (1) Fish oil oxidation will inevitably lower the amounts of its active constituents, eicosapentaenoic
- [Harnessing the Power of Gut-Derived Lantibiotics in the Fight Against Pathogens and for Gut Health Preservation](https://plminstitute.org/hot-topics/microbiome/harnessing-the-power-of-gut-derived-lantibiotics-in-the-fight-against-pathogens-and-for-gut-health-preservation/) - Exciting news has emerged from the world of science that could change how we think about keeping our guts healthy and our food safe. Using genomic mining, researchers have found something amazing in our gut ecosystem: special substances called gut-derived class I lantibiotics. These are like the well-known food preservative nisin, but they come from
- [Support Healthy Weight and Blood Sugar Levels With Evidence-based Ingredients](https://plminstitute.org/hot-topics/epigenetics/support-healthy-weight-and-blood-sugar-levels-with-evidence-based-ingredients-2/) - Written by Laura Dan, BSc, NDTR The prevalence of obesity and metabolic conditions, including prediabetes and diabetes, presents a significant public health concern. The Centers for Disease Control and Prevention (CDC) estimates that as of 2020 nearly 42% of the American population has obesity. (5) Meanwhile, it’s estimated that 11.6% of the U.S. population has
- [Invisible Threats: How Environmental Toxins Compromise Brain Health and Development](https://plminstitute.org/hot-topics/planetary-health/invisible-threats-how-environmental-toxins-compromise-brain-health-and-development/) - Medically reviewed by Dr. Amitha Kalaichandran MD MHS Invisible Threats: How Environmental Toxins Compromise Brain Health and Development In our day-to-day lives, we're bombarded with invisible toxins that pose significant risks to our health, especially our brain health. From the air we breathe to the habits we might not even think twice about, environmental toxins
- [Unlocking the Antioxidant Code: Dietary Deficiencies Linked to Alzheimer’s Progression](https://plminstitute.org/hot-topics/epigenetics/unlocking-the-antioxidant-code-dietary-deficiencies-linked-to-alzheimers-progression/) - Medically reviewed by Dr. Amitha Kalaichandran MD MHS Alzheimer's disease is a type of dementia that we haven't yet found a way to treat or cure. It affects millions of people worldwide, making it difficult for them to remember things, solve problems, and do everyday tasks. Even though we've been researching Alzheimer's for a long
- [Tracking Sleep Stages: Are You Getting Enough Deep Sleep?](https://plminstitute.org/hot-topics/health-fitness/tracking-sleep-stages-are-you-getting-enough-deep-sleep/) - Submitted by the Metagenics Marketing Team For optimal health, most adults should aim for about seven to nine hours of sleep per night. Maybe you’re well within that range—but are you getting enough deep sleep?1 When your head hits the pillow, it takes some time to get into the deep sleep stage, and if you
- [Implications of the Vagus Nerve and Immune System Connection for Inflammation, Autoimmune Diseases & Mental Health](https://plminstitute.org/plmi-blog/implications-of-the-vagus-nerve-and-immune-system-connection-for-inflammation-autoimmune-diseases-mental-health/) - The vagus nerve is interconnected with nearly all the systems of the body and has a profound role in modulating immune function. It mediates vital processes crucial for the health of the body and mind. The functioning of the vagus nerve is significant in regulating homeostatic facets of health, and we can influence it. Cues
- [The next generation of mRNA vaccines is on its way](https://plminstitute.org/hot-topics/immune-health/the-next-generation-of-mrna-vaccines-is-on-its-way/) - By Cassandra Willyard Welcome back to The Checkup! Today I want to talk about … mRNA vaccines. I can hear the collective groan from here, but wait—hear me out! I know you’ve heard a lot about mRNA vaccines, but Japan recently approved a new one for covid. And this one is pretty exciting. Just like
- [Support Healthy Weight and Blood Sugar Levels With Evidence-based Ingredients](https://plminstitute.org/hot-topics/epigenetics/support-healthy-weight-and-blood-sugar-levels-with-evidence-based-ingredients/) - Written by Laura Dan, BSc, NDTR The prevalence of obesity and metabolic conditions, including prediabetes and diabetes, presents a significant public health concern. The Centers for Disease Control and Prevention (CDC) estimates that as of 2020 nearly 42% of the American population has obesity. (5) Meanwhile, it’s estimated that 11.6% of the U.S. population has
- [The Role of Diet and Nutrition in Managing Symptoms of ADHD: What Practitioners Should Know](https://plminstitute.org/hot-topics/epigenetics/the-role-of-diet-and-nutrition-in-managing-symptoms-of-adhd-what-practitioners-should-know/) - by Dr. Cora Stover ND Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that affects millions of people. According to the CDC, ADHD roughly affects about 6 million (9.8%) of youth, whereas NIH claims 562.8 million (9.8%) of adults. People who suffer from ADHD tend to have learning disabilities, which affect their school, social,
- [Go Beyond Basic Wellness Support with a Daily Multivitamin](https://plminstitute.org/hot-topics/health-fitness/go-beyond-basic-wellness-support-with-a-daily-multivitamin-2/) - Feeling our best, maintaining our health, and aging gracefully is what we all aspire to do, and achieving this may be more accessible than you think. Simply making better decisions daily, like choosing to eat more nutrient-dense foods, can put us on a path to health and wellness.1 We all know that everyday life can
- [Visage Imaging launches diagnostic imaging platform for Apple Vision Pro](https://plminstitute.org/hot-topics/technology/visage-imaging-launches-diagnostic-imaging-platform-for-apple-vision-pro/) - Diagnostic imaging and multimedia company Visage Imaging announced the launch of Visage Ease VP, an immersive imaging platform that can be used on Apple's augmented reality headset, Apple Vision Pro. Visage offers cloud-based, AI-enabled enterprise imaging software, including Visage 7, Visage Ease and Visage Ease Pro, that allows users to examine diagnostic images and collaborate with
- [Innovative Probiotics for Metabolic Health](https://plminstitute.org/hot-topics/health-fitness/innovative-probiotics-for-metabolic-health-2/) - In 2021, it was estimated that 38% of the U.S. adult population had pre-diabetes. Thankfully, research has identified strategies for supporting individuals with diabetes and other metabolic disorders, such as a nutrient-rich diet, regular physical activity, weight management, quality sleep, smoking cessation, and routine health monitoring. (4) But where do dietary supplements come in? Supplements
- [Why is the Vagus Nerve Important to Physical and Mental Health?](https://plminstitute.org/plmi-blog/why-is-the-vagus-nerve-important-to-physical-and-mental-health/) - The vagus nerve is the longest cranial nerve, serving as a bidirectional highway between the brainstem and internal organs of the body. This fascinating nerve is significant in modulating homeostasis, integral for regulating various physiological and psychophysiological aspects of health (1). The vagus, or “wandering nerve,” exerts a profound influence on modulating functions in the
- [SIBO: What the Science Says](https://plminstitute.org/hot-topics/microbiome/sibo-what-the-science-says/) - Written by Kayla Robinson, BKin, RHN If you suffer from chronic gastrointestinal issues such as diarrhea, abdominal pain, and bloating, you may have a bacterial imbalance in your gut. Small intestinal bacterial overgrowth, commonly referred to by its acronym SIBO, and occasionally also called small bowel bacterial overgrowth, has gained attention in recent years as
- [Harnessing Holy Basil for Stress Relief and Hormonal Regulation in Endocrine Health](https://plminstitute.org/hot-topics/epigenetics/harnessing-holy-basil-for-stress-relief-and-hormonal-regulation-in-endocrine-health/) - by Dr. JheriAnne Preston ND, CNS® Stress has a profound effect on human physiology. Stress can wreak havoc on your well-being, from the respiratory and cardiovascular systems to the musculoskeletal framework, the nervous system, and endocrine systems. Utilizing natural medicine therapies for stress management is a viable avenue. Holy Basil for stress and hormonal health
- [7 Steps to Prepare for a Metabolic Detox](https://plminstitute.org/hot-topics/health-fitness/7-steps-to-prepare-for-a-metabolic-detox-2/) - By the Metagenics Editorial Team When working toward any goal, preparation is key for success. And if you're thinking about starting a metabolic detoxification program, it's important to begin your journey with a positive mindset. Detox programs may seem intimidating, especially for beginners, but they don't have to be. To stay motivated, remember why you
- [AI identified as a top risk for healthcare](https://plminstitute.org/hot-topics/technology/ai-identified-as-a-top-risk-for-healthcare/) - Susan Morse, Executive Editor AI and new technologies are among the top five management risks providers face in 2024, according to an annual report by Kodiak Solutions. The other risks are based around financial performance, competition, workforce and cybersecurity, with AI and new technologies affecting most of those categories, according to the report. The efficiencies
- [Functional Medicine Nutrition and Exercise Protocol for Aging Populations: Enhancing Longevity and Well-Being](https://plminstitute.org/hot-topics/epigenetics/functional-medicine-nutrition-and-exercise-protocol-for-aging-populations-enhancing-longevity-and-well-being/) - by Dr. Laura DeCesaris Master Clinical Nutrition, Chiropractic, A4M Fellowship The World Health Organization estimates that the number of people aged 60 or older will reach 2 billion (22% of the global population) by 2050, highlighting the growing importance of health maintenance in aging populations. With aging comes an increased risk of chronic diseases, mobility
- [Research update: A parallel, double-blind, randomized clinical trial on the effect of Plantago psyllium on cardiovascular markers in obese adolescents](https://plminstitute.org/hot-topics/health-fitness/research-update-a-parallel-double-blind-randomized-clinical-trial-on-the-effect-of-plantago-psyllium-on-cardiovascular-markers-in-obese-adolescents/) - Written by Dr. Clara Sage Sartor, ND, BSc Research Update articles are produced in order to keep practitioners up to date on impactful research that is relevant to the field of integrative medicine. These articles may contain summaries of recent studies, events, or other industry news that advance current knowledge and standards of care. The
- [The first gene-editing treatment: 10 Breakthrough Technologies 2024](https://plminstitute.org/hot-topics/technology/the-first-gene-editing-treatment-10-breakthrough-technologies-2024/) - By Antonio Regalado WHO CRISPR Therapeutics, Editas Medicine, Precision BioSciences, Vertex Pharmaceuticals WHEN Now The first gene-editing cure has arrived. Grateful patients are calling it “life changing.” It was only 11 years ago that scientists first developed the potent DNA-snipping technology called CRISPR. Now they’ve brought CRISPR out of the lab and into real medicine
- [7 Steps to Prepare for a Metabolic Detox](https://plminstitute.org/hot-topics/health-fitness/7-steps-to-prepare-for-a-metabolic-detox/) - By the Metagenics Editorial Team When working toward any goal, preparation is key for success. And if you're thinking about starting a metabolic detoxification program, it's important to begin your journey with a positive mindset. Detox programs may seem intimidating, especially for beginners, but they don't have to be. To stay motivated, remember why you
- [The Science Behind Mindful Eating: How It Impacts Digestion and Overall Health](https://plminstitute.org/hot-topics/health-fitness/the-science-behind-mindful-eating-how-it-impacts-digestion-and-overall-health/) - by Brittney Bertagna RN Are you aware that the way you eat can have a significant impact on your digestion and overall health? In this blog post, we will delve into the fascinating world of mindful eating and explore its profound effects on our digestive system and well-being. Mindful eating is not just about what
- [Signs, Symptoms & Root Causes of Cognitive Decline in Peri & Menopausal Women](https://plminstitute.org/plmi-blog/signs-symptoms-root-causes-of-cognitive-decline-in-peri-menopausal-women/) - Hormonal changes leading up to and during menopause can cause significant cognitive disruptions for women, further compounding an already difficult transition process. Cognitive decline experienced in perimenopause and menopause results from a multitude of factors, all driving neurophysiological alterations—affecting the body and brain. Some common signs and symptoms experienced in women during this time include
- [The Prediabetes Diet: Building a Balanced Meal Plan for Optimal Blood Sugar Control](https://plminstitute.org/hot-topics/health-fitness/the-prediabetes-diet-building-a-balanced-meal-plan-for-optimal-blood-sugar-control/) - by Brittney Bertagna RN Are you having difficulty creating a meal plan that effectively controls blood sugar levels? If so, you're not alone. Many individuals with prediabetes face similar challenges when it comes to managing their condition naturally. But fear not, because, in this article, we will unravel the mystery behind building a balanced meal
- [Innovative Probiotics for Metabolic Health](https://plminstitute.org/hot-topics/microbiome/innovative-probiotics-for-metabolic-health/) - Written by Cait Fortier, RHN, BA In 2021, it was estimated that 38% of the U.S. adult population had pre-diabetes. Thankfully, research has identified strategies for supporting individuals with diabetes and other metabolic disorders, such as a nutrient-rich diet, regular physical activity, weight management, quality sleep, smoking cessation, and routine health monitoring. (4) But where
- [How to Tell if Supplements are Fake: Identifying Genuine and Fake Supplements](https://plminstitute.org/hot-topics/personalized-medicine/how-to-tell-if-supplements-are-fake-identifying-genuine-and-fake-supplements/) - Written by Jayelah Bush, BScN With so many supplements on the market, quality standards, including accuracy and safety, can vary significantly among supplement manufacturers. Although dietary supplements are regulated in the U.S. by the Food and Drug Administration (FDA), these regulations don’t define precise quality standards. (1) Whether they contain the wrong botanical species or
- [Folate: What You Need To Know](https://plminstitute.org/hot-topics/personalized-medicine/folate-what-you-need-to-know/) - Written by Katrina Krutzik, BS Many of us have heard of either folic acid, folate, or vitamin B9, all common names for this important vitamin. But what many of us don’t know is what it is and how it can be beneficial. Keep reading to learn more about the various benefits of folate, from supporting
- [Alternative Testing Options To The Top Vibrant America & Vibrant Wellness Tests](https://plminstitute.org/hot-topics/technology/alternative-testing-options-to-the-top-vibrant-america-vibrant-wellness-tests/) - By: Dr. Jessica Christie ND, CNS Starting Feb. 1st 2024, Vibrant is closing off all partnerships and moving in a different strategic direction. We started Rupa with a mission to support practitioners in bringing Root Cause Medicine to the world. 🌎 We’re committed to this and to working with partners who also believe in this.
- [How Do Physiological Changes Induced In Menopause Impact Mental Health?](https://plminstitute.org/plmi-blog/how-do-physiological-changes-induced-in-menopause-impact-mental-health/) - It is estimated that 1.3 million women transition into menopause each year (1). Menopause is defined as 12 months of amenorrhea, indicating the end of reproductive capacity, along with marked hormonal changes (2). Hormones play an integral role in modulating systemic and psychobiological aspects of health. The hormonal alterations that occur in perimenopause and menopause
- [AI may improve medical networks' cybersecurity](https://plminstitute.org/hot-topics/technology/ai-may-improve-medical-networks-cybersecurity/) - Cybersecurity officers are up against well-equipped adversaries like crime syndicates, says Richard Staynings, chief security strategist at Cylera. AI can help automate and improve cybersecurity tools if adequately implemented. Full Article
- [Carrum Health, Florida Cancer Institute partner to expand breast cancer care](https://plminstitute.org/hot-topics/health-fitness/carrum-health-florida-cancer-institute-partner-to-expand-breast-cancer-care/) - Carrum Health, a digital marketplace for employers to purchase bundled healthcare services, announced it has partnered with Florida Cancer Specialists & Research Institute to offer employers in Florida breast cancer care services. Carrum Health offers a value-based platform that allows self-funded employers to buy specialty care, focusing on surgical and cancer care. It provides a
- [Go Beyond Basic Wellness Support with a Daily Multivitamin](https://plminstitute.org/hot-topics/personalized-medicine/go-beyond-basic-wellness-support-with-a-daily-multivitamin/) - Feeling our best, maintaining our health, and aging gracefully is what we all aspire to do, and achieving this may be more accessible than you think. Simply making better decisions daily, like choosing to eat more nutrient-dense foods, can put us on a path to health and wellness.1 We all know that everyday life can
- [The Link Between Akkermansia Muciniphila and a Healthy Gut Barrier](https://plminstitute.org/plmi-blog/the-link-between-akkermansia-muciniphila-and-a-healthy-gut-barrier/) - Akkermansia muciniphila, a promising strain of bacterium discovered two decades ago, has gained an increase in recognition for its role in modulating a healthy gut barrier, which is crucial for countless aspects of our health. Not only is maintaining the integrity of the GI intestinal barrier imperative for digestion and absorption of nutrients, but also
- [Vitamin C Health Benefits and Best Sources](https://plminstitute.org/hot-topics/vitamin-c-health-benefits-and-best-sources/) - In the body, vitamin C supports immune health, acts as an antioxidant, and assists in collagen synthesis. (11) Vitamin C functions as a cofactor for enzymes involved in regulating gene transcription and synthesizing certain neurotransmitters and hormones. (3) In the immune system, vitamin C supports the function of the epithelial barrier, the cells that provide
- [Top 7 Benefits of Magnesium](https://plminstitute.org/hot-topics/top-7-benefits-of-magnesium/) - Magnesium is an essential mineral, involved in over 300 enzymatic reactions in the body, from nerve and muscle function to protein synthesis and blood sugar regulation–we can’t live without it. (4)(13) Not only is magnesium essential to optimal health, but it has also been researched for its ability to prevent chronic inflammatory diseases such as
- [Akkermansia Muciniphila: The Benefits and Risks of the Next-Generation Probiotic](https://plminstitute.org/hot-topics/akkermansia-muciniphila-the-benefits-and-risks-of-the-next-generation-probiotic/) - In the fascinating world of our microbiome, there is one bacterium that has been making waves, and that is Akkermansia muciniphila. Among the trillions of bacteria residing in our body (yes, that’s 10 times more than our own cells!), this particular species has caught the attention of researchers and health enthusiasts alike. Discovered about 20 years
- [Impact of Akkermansia on Healthy Weight and Blood Sugar Metabolism](https://plminstitute.org/plmi-blog/impact-of-akkermansia-on-healthy-weight-and-blood-sugar-metabolism/) - Research surrounding the microbiome has been explosive in the past decade, and will only continue to emerge, providing novel implications for our health. Specific strains of microbiota have been shown to have specialized roles in the body, and a growing body of research suggests that Akkermansia, a strain of bacteria we have in the microbiome,
- [The first CRISPR cure might kick-start the next big patent battle](https://plminstitute.org/hot-topics/the-first-crispr-cure-might-kick-start-the-next-big-patent-battle/) - By Antonio Regalado That’s a real nice CRISPR cure you have there. It would be a pity if anything happened to it. Okay. Drop the tough-guy accent and toss the black fedora aside. But I do believe that similar conversations could be occurring now that a historic gene-editing cure is coming to market, as soon
- [Why Is It Important to Understand Immune System Aging?](https://plminstitute.org/plmi-blog/why-is-it-important-to-understand-immune-system-aging/) - Why does the health of our immune system matter? What role does it play in aging and disease? A growing body of research suggests it greatly matters, playing a pivotal role in aging, disease, and longevity. Understanding the mechanisms that influence aging and compromise immunity is paramount in negating their effects while optimizing health, vitality,
- [Strategies to Reduce Immune Age & Increase Health Span](https://plminstitute.org/plmi-blog/strategies-to-reduce-immune-age-increase-health-span/) - What if you could become healthier while getting more youthful? Immunity is essential for longevity, and we know now more than ever how true this concept is. The aging immune system is associated with a number of chronic health conditions beyond aging. Implementing daily lifestyle practices that support and optimize the body’s immunity at a
- [The Future of Brain Health](https://plminstitute.org/plmi-blog/contributors/the-future-of-brain-health/) - 5 Key learnings from 2023 By Austin Perlmutter, MD Over the last several days, I had the honor of attending and presenting at the annual Personalized Lifestyle Medicine Institute Conference. This year’s theme was “neuroimmunity,” which meant the focus was squarely on brain health. Speakers at the conference included some of the world’s leading researchers
- [Nitric Oxide Levels & Their Role in Menopause Symptoms](https://plminstitute.org/plmi-blog/nitric-oxide-levels-their-role-in-menopause-symptoms/) - What if many of the symptoms associated with menopause could be reduced, simply by optimizing underlying biochemical processes in the body that play a role? Menopause is marked by decreased levels of endogenous estrogen, impacting production of nitric oxide, an important gaseous signaling molecule for health and vitality (1). With a fleeting life of less
- [What is the Role of Nitric Oxide and How Does It Impact Health?](https://plminstitute.org/plmi-blog/what-is-the-role-of-nitric-oxide-and-how-does-it-impact-health/) - Nitric oxide is a critical signaling molecule and gaseous cellular messenger produced in the body, which has significant regulatory roles in terms of our health. Adequate levels of this molecule are imperative for supporting a myriad of biological functions pertaining to optimal wellness. Among its many physiological functions, nitric oxide (NO) has a role in
- [Can DNA Methylation and Epigenetic Age Clocks Provide Insights Into Personalized Anti-aging Interventions?](https://plminstitute.org/plmi-blog/can-dna-methylation-and-epigenetic-age-clocks-provide-insights-into-personalized-anti-aging-interventions/) - Why do we age, and what can we do about it? We’ve been told that aging is a part of life, a process that we just have to accept. While aging is indeed inevitable, understanding how we are aging in terms of our biology can provide valuable insights into not only how gracefully we can
- [Can Lifestyle Choices Influence DNA Methylation?](https://plminstitute.org/plmi-blog/can-lifestyle-choices-influence-dna-methylation/) - What if you could control how gracefully you aged? Or reduce the risk of developing a chronic health condition? While we don’t have control over the genes we are born with, we do have control over how those genes get expressed. The choices we make every day, in terms of our nutrition and lifestyle, have
- [Causaly scores $60M to enhance AI platform for biomedical research](https://plminstitute.org/hot-topics/technology/causaly-scores-60m-to-enhance-ai-platform-for-biomedical-research/) - By Jessica Hagen Causaly, a tech company using AI to interpret large datasets and literature, announced it closed a $60 million Series B round led by ICONIQ Growth. Marathon Venture Capital, Index Ventures, Pentech Ventures, EBRD and Visionaries Club also participated in the round, as did former chairman and CEO of Johnson & Johnson Alex Gorsky
- [After 25 years of hype, embryonic stem cells are still waiting for their moment](https://plminstitute.org/hot-topics/technology/after-25-years-of-hype-embryonic-stem-cells-are-still-waiting-for-their-moment/) - By Antonio Regalado Twenty-five years ago, in 1998, researchers in Wisconsin isolated powerful stem cells from human embryos. It was a fundamental breakthrough for biology, since these cells are the starting point for human bodies and have the capacity to turn into any other type of cell—heart cells, neurons, you name it. National Geographic would
- [Lisa's Natural Resolution of Seasonal Affective Disorder: A Case Study](https://plminstitute.org/hot-topics/health-fitness/lisas-natural-resolution-of-seasonal-affective-disorder-a-case-study/) - Seasonal affective disorder, commonly known as SAD, is a type of depression that happens during certain parts of the year, fall and winter being the most common. It has been suggested that the shortening of days and less daylight trigger a chemical change in the brain. This change may lead to depression. Symptoms may include
- [BRINGING TOGETHER THE WORLD OF GENETICS AND EPIGENETICS](https://plminstitute.org/newsletters/bringing-together-the-world-of-genetics-and-epigenetics/) - It is of great concern that I have observed over the last few years a binary approach to the fields of genetics and epigenetics. Understanding the contribution of genetics and epigenetics towards health is not an ‘either’ ‘or’ equation, it is both. Genetics and epigenetics are the Yin and Yang of understanding how the genes
- [Circadian Rhythms, Chronodisruption & the Microbiota: Timing is Everything](https://plminstitute.org/plmi-blog/circadian-rhythms-chronodisruption-the-microbiota-timing-is-everything/) - Are the trillions of microorganisms in the human gut sensitive to time? It is safe to say that many human biological processes have cycles of time, or “clocks” associated with them. Biological rhythms may follow a day/night cycle, a 24-hour cycle, a monthly cycle, or even an annual cycle. Researchers studying digestion and the microbiota
- [Q3 Newsletter: Epi-wellness: Taking the Lead in the DNA-Diet Dance](https://plminstitute.org/newsletters/q3-newsletter-epi-wellness-taking-the-lead-in-the-dna-diet-dance/) - Epi-wellness: Taking the Lead in the DNA-Diet Dance – Lucia Aronica, PhD Our genes are mighty molecules. They can have powerful effects on the way we look, feel, and respond to signals from the world around us. But they usually work in big networks of thousands and millions of tiny genetic variations that interact with
- [Dietary Supplements on the Hot Seat – Again](https://plminstitute.org/newsletters/dietary-supplements-on-the-hot-seat-again/) - Jeffrey Bland, Ph.D. Over the past forty-plus years, I have been involved in the dietary supplement area of research and development; there have been periodic attacks on the industry and the concept of dietary supplementation by factions within the medical and government regulatory communities. The issue has again been raised with several recent editorials in
- [Dr. Jeff Bland — Top of Mind](https://plminstitute.org/newsletters/dr-jeff-bland-top-of-mind/) - We are rapidly closing out 2022 and making the transition from a life fully occupied by the challenges of COVID-19 to that of what will be the “new normal”. One thing is for certain- change is the only constant (and that is the oxymoron of our age). With regard to our health, we now recognize
- [Augmented reality spine surgery platform Augmedics scores $82.5M](https://plminstitute.org/hot-topics/technology/augmented-reality-spine-surgery-platform-augmedics-scores-82-5m/) - By Jessica Hagen Augmedics, an augmented reality surgical-navigation platform, has scored $82.5 million in Series D financing led by CPMG. Evidity Health Capital joins the round as a syndicate partner. Current investors Revival Healthcare Capital, H.I.G. Capital, Almeda Ventures and others participated in the round. WHAT IT DOES Augmedics xvision Spine System, which received FDA clearance in
- [Women’s Health Supplements: 4 Protocols to Support Your Patients’ Health](https://plminstitute.org/hot-topics/health-fitness/womens-health-supplements-4-protocols-to-support-your-patients-health/) - Written by Nada Ahmed, BSc Throughout adulthood, women experience unique health concerns, such as pregnancy and menopause, which we can support with integrative therapies. Among Fullscript’s many resources available to practitioners, Fullscript protocols outline evidence-based therapies for various health concerns. These protocols, which serve as a foundation for building patient treatment plans, are based on
- [The New Era of Primary Care Medicine: How AI is Transforming Patient Care and Physician Practices](https://plminstitute.org/hot-topics/technology/the-new-era-of-primary-care-medicine-how-ai-is-transforming-patient-care-and-physician-practices/) - by Dr. Chil Khakham MBA, NMD Depending on your perspective, the future can either be compelling or threatening with using artificial intelligence (AI) in primary care. AI has the capacity to revolutionize the healthcare industry, allowing for more patient-centered care and accurate diagnosis. However, this technology can come with some unintended consequences and ethical issues. No
- [What is The Cardiometabolic Food Plan?](https://plminstitute.org/hot-topics/health-fitness/what-is-the-cardiometabolic-food-plan/) - by Kellie Blake RDN, LD, IFNCP Great cardiometabolic health is the first line of defense against serious chronic diseases like heart disease and type 2 diabetes. But one study of 55,000 American adults found less than 7% had optimal levels of the major determinants of cardiometabolic health. While these types of studies may seem disheartening, all
- [Exploring the relationship between epigenetic aging and gut microbiome composition in physically fit men and women](https://plminstitute.org/hot-topics/epigenetics/exploring-the-relationship-between-epigenetic-aging-and-gut-microbiome-composition-in-physically-fit-men-and-women/) - By Vijay Kumar Malesu In a recent study posted to the medRxiv* preprint server, researchers investigate the relationship between the gut microbiome, physical fitness, and epigenetic aging in physically fit individuals. Numerous studies have reported that a healthy lifestyle can enhance an individual’s lifespan and reduce lifestyle-related diseases. Epigenetic clocks, which measure biological age
- [Infant Rapid Genome Sequencing Yields More Diagnoses Than Targeted Gene Panels, Study Finds](https://plminstitute.org/hot-topics/technology/infant-rapid-genome-sequencing-yields-more-diagnoses-than-targeted-gene-panels-study-finds/) - by Andrea Anderson NEW YORK – Early results from a national study in the US suggest that rapid whole-genome sequencing (WGS) outperforms targeted gene panel sequencing when it comes to diagnosing newborns and infants with suspected genetic conditions. “The molecular diagnostic yield for genomic sequencing was higher than a targeted neonatal gene sequencing test, but
- [Epigenetic study links DNA methylation to diseases including breast cancer and diabetes](https://plminstitute.org/hot-topics/epigenetics/epigenetic-study-links-dna-methylation-to-diseases-including-breast-cancer-and-diabetes/) - by Nick Paul Taylor An epigenetic study of more than 18,000 people has found links between DNA methylation and diseases including breast cancer and type 2 diabetes. Writing in the journal PLoS Medicine, researchers at the University of Edinburgh described the results of an analysis of DNA methylation at around 750,000 cytosine-phosphate-guanine dinucleotide (CpG) sites
- [Covid hasn’t entirely gone away—here’s where we stand](https://plminstitute.org/hot-topics/health-fitness/covid-hasnt-entirely-gone-away-heres-where-we-stand/) - By Jessica Hamzelou We’re well into summer here in the Northern Hemisphere. For a parent of two young children, that means ice creams, water fountains, picnics, and—inevitably—coughs and colds. My eldest told me she was feeling poorly this morning, and the youngest crawled into my bed to cough in my face. It’s not just kids,
- [Types of Hypotension](https://plminstitute.org/hot-topics/health-fitness/types-of-hypotension/) - by Megan Feldt, BSc Hypotension, commonly referred to as low blood pressure, is a less common condition than hypertension (high blood pressure). However, it can be just as serious and can be an indication of an underlying health condition. (11) There are different types of hypotension. Keep reading to understand the different types of hypotension,
- [FeelBetter raises $5.9M for AI-enabled medication management platform](https://plminstitute.org/hot-topics/technology/feelbetter-raises-5-9m-for-ai-enabled-medication-management-platform/) - by Jessica Hagen FeelBetter, a machine learning-enabled medication-management platform focused on polypharmacy, announced it secured $5.9 million in funding led by Firstime Ventures and Shoni Health Ventures. Random Forest VC, The Group Ventures, and existing FeelBetter investor Triventures also participated in the round. The latest round brings the company’s total raise to $8 million. Continue
- [Enhancing Sleep with Gut Microbiome Manipulation](https://plminstitute.org/plmi-blog/enhancing-sleep-with-gut-microbiome-manipulation/) - Functional Medicine providers are well aware of the complex and interconnected nature of the human body. Sleep quality is a fundamental aspect of human health and well-being, and disruptions in sleep patterns can lead to myriad health issues (1). Recent advances in research have revealed an exciting and promising avenue to enhance sleep quality and
- [Eat Your HiPR-FISH, HUManN – A Brief Overview of Metagenomic Tech Through the Lens of Microbiome Research](https://plminstitute.org/plmi-blog/eat-your-hipr-fish-humann-a-brief-overview-of-metagenomic-tech-through-the-lens-of-microbiome-research/) - For understanding the microbiome, revolutions in DNA sequencing technology have opened insights into the taxonomy and functionality of the teeming masses of microbes living in the guts of mammals. Efforts to identify and characterize microbes are daunting because of the sheer volume of microbial matter present in the gut. The human gut microbiome, which is
- [Wheels Within Wheels: Influence of the Gut-Brain Axis and HPA Axis](https://plminstitute.org/plmi-blog/wheels-within-wheels-influence-of-the-gut-brain-axis-and-hpa-axis/) - Advances in science have established bidirectional, integrated systems in the body that connect the gut to the brain in feedback loops that expand in scope and number as investigative tools improve. As hardware, computing techniques, and even AI assist the examination of the relationships of bodily systems, a complex picture of mutual influence emerges. The
- [Hidden Influencers – An Increasingly Complex Picture of Health](https://plminstitute.org/plmi-blog/hidden-influencers-an-increasingly-complex-picture-of-health/) - It’s almost fractal in nature. Researchers pushing the boundaries of technological advances get hints of anatomy and physiology that govern or influence how the human body functions. They pursue the “what, how, and why” until the picture becomes clearer. Facts are teased out, anatomy is identified, functions are described, and theories are forwarded. As time
- [Challenges for Root Cause Analysis in Acute and Chronic Illnesses](https://plminstitute.org/plmi-blog/challenges-for-root-cause-analysis-in-acute-and-chronic-illnesses/) - It’s an understatement to say that detecting the underlying root cause of human illness is very challenging. There may be a 7-headed hydra of recognizable signs and symptoms, all stemming from a single source, the “root cause.” However, being able to trace those seven manifestations to one root cause is extremely difficult. (Not to say
- [DNA Methylation – Examples of Epigenetic Effects Upon the Immune System](https://plminstitute.org/plmi-blog/dna-methylation-examples-of-epigenetic-effects-upon-the-immune-system/) - DNA methylation has an interesting role in the immune system. Through DNA methylation, the expression of genes can be altered without altering the underlying genetic code, so is considered epigenetic, and yet these “temporary” or reversible changes are heritable in some cases. This mechanism is seen throughout the maturation of parts of the adaptive immune
- [Pharmacopoeia Phantastica: Psychedelics & Neuroplasticity](https://plminstitute.org/plmi-blog/pharmacopoeia-phantastica-psychedelics-neuroplasticity/) - Mankind has long been intrigued by hallucinatory substances that have powerful effects on the psyche. Early in human history, substances in mushrooms and cacti were found to invoke visual and auditory hallucinations, intense feelings, and profound insights. Many indigenous cultures throughout the millennia have revered these altered states of consciousness from so-called “psychedelic” substances, judging
- [Malnutrition in Obesity – Poised to Benefit from Personalized Lifestyle Medicine](https://plminstitute.org/plmi-blog/malnutrition-in-obesity-poised-to-benefit-from-personalized-lifestyle-medicine/) - It seems contradictory to observe obesity and malnutrition in the same human. However, it’s becoming a more recognized condition due to advances in modern testing. One would think that the number of calories consumed would provide the nutrients needed by the body to be healthy, even if some of the calories were not from healthy
- [Looking for Clues: Nutrition and GI-Related Clinical Assessments in the Functional Medicine Toolkit](https://plminstitute.org/plmi-blog/looking-for-clues-nutrition-and-gi-related-clinical-assessments-in-the-functional-medicine-toolkit/) - The Functional Medicine practitioner must often take the role of sleuth in determining the root cause of a patient’s health issue. Picking the correct tests saves time for the patient and for the practitioner – what cannot be positively identified by tests often must be figured out by the process of elimination, which takes considerable
- [The Sleep–Immune System: Disrupted Sleep in the Days of COVID](https://plminstitute.org/plmi-blog/the-sleep-immune-system-disrupted-sleep-in-the-days-of-covid/) - The repercussions from the lack of sleep are self-evident – decreased mental clarity, increased probability of mistakes, and perhaps a sharp increase in the desire for caffeine. Sleep – quality sleep – is vital to humans and is so physiologically important that every species in the whole animal kingdom requires it (1). Unsurprisingly, Americans are
- [Microbiome Manipulations to Prevent Neurodegenerative Diseases](https://plminstitute.org/plmi-blog/microbiome-manipulations-to-prevent-neurodegenerative-diseases/) - The risk of having a neurodegenerative disease rises as age increases (1), and as a large group of people in the U.S. population ages, the potential health impact is alarming. Parkinson’s and Alzheimer’s are the most prevalent neurodegenerative diseases in the United States, with about 6 million people living with Alzheimer’s and 1 million living
- [Collision Course in the Gut Microbiota? Nano meets Nutrition](https://plminstitute.org/plmi-blog/collision-course-in-the-gut-microbiota-nano-meets-nutrition/) - There are many beneficial plant substances for human health, but what’s the best way to get them into the body? The encapsulation of substances goes back in history a few decades, with the invention of gelatin capsules being a massive breakthrough for delivering medicines and plant-derived products to the human gut. Encapsulation helps target specific
- [Epigenetics and Trained Immunity](https://plminstitute.org/plmi-blog/epigenetics-and-trained-immunity/) - The ability of the human immune system to remember exposures to pathogens and antigens forms the basis for robust protection from diseases. Some cells of the immune system can be exposed to certain stimuli that have the ability to train the cells to respond in specific ways, modifying their behavior. The exciting advances in research
- [Epigenetics and Mathematics Combine to Predict Cancer Cells’ Behavior](https://plminstitute.org/hot-topics/epigenetics/epigenetics-and-mathematics-combine-to-predict-cancer-cells-behavior/) - Researchers published a study “Epigenetics as a mediator of plasticity in cancer” in Science that they say addresses new quantitative approaches to better define and measure epigenetic defects in gene function and their interplay with the genetic landscape of cancer. In cancer development, epigenetic changes promote phenotypic plasticity, the continued change in tumor cell behavior
- [Immune System Targets for Anti-Aging Therapies](https://plminstitute.org/plmi-blog/immune-system-targets-for-anti-aging-therapies/) - Fractal-like, interconnected systems in the human body operate simultaneously at the macro and micro levels with varying degrees of overlap and influence. One advantage of these varying circles of influence is the ability to make a small change upstream with multiple positive benefits downstream. Emerging as a hotbed for changes that can defy aging characteristics,
- [The Gut Mucosal Immune System: Where Microbiome Meets Immunity](https://plminstitute.org/plmi-blog/the-gut-mucosal-immune-system-where-microbiome-meets-immunity/) - Food must be ingested, broken down, and absorbed selectively across specialized tissues, allowing rejected items to continue through the gastrointestinal (GI) system and out of the body. Absorption of food is a complicated affair because food contains necessary nutrients along with numerous antigens capable of inducing an immune response, such as gluten or milk proteins. The body
- [Immunomodulatory Interventions of Gut Mucosal Immune System Structures](https://plminstitute.org/plmi-blog/immunomodulatory-interventions-of-gut-mucosal-immune-system-structures/) - The mucosal immune system lies at points of entry to the body, where the inside meets the outside, such as the sinuses and the mouth. As the name implies, mucus is employed to defend the body at these points. The gut mucosal immune system (MIS) is one of the most complex points of entry. Tight control
- [Neuro Disorders, Mental Health & the Microbiota: Cases for Consideration](https://plminstitute.org/plmi-blog/neuro-disorders-mental-health-the-microbiota-cases-for-consideration/) - The famous Greek physician Hippocrates reportedly said, “Our food should be our medicine and our medicine should be our food.” Modern science is quickly proving exactly how dietary intake can influence human health, including mood and mental health. Modern tools that include the -omics, artificial intelligence, hardware, and software, have helped identify an essential player in this
- [The Microbiota-Gut-Brain Axis & Brain Health: Identifying Needs in the Microbiome Research Community](https://plminstitute.org/plmi-blog/the-microbiota-gut-brain-axis-brain-health-identifying-needs-in-the-microbiome-research-community/) - Metagenomics, metabolomics, and whole genome sequencing (WGS) are revealing the exquisite complexity and seemingly boundless opportunities of the microbiota-gut-brain (MGB) axis to positively impact brain health. Advanced research techniques are being developed even as the hardware and software evolve to handle the huge amount of data created by microbiome research. The vast amount of microorganisms
- [The Relationship Between Gut Health and Menopause](https://plminstitute.org/plmi-blog/the-relationship-between-gut-health-and-menopause/) - Menopause, the waning of reproductive capability in women as they age, involves a change in female hormones that can impact mood, sleep, digestion, and many aspects of quality of life. Once the menses cease for 12 or more months, official menopause has begun. However, some negative hormone-related symptoms can be felt long before menopause, sending
- [Role of Methylation in Menopause and Strategies for Improvement](https://plminstitute.org/plmi-blog/role-of-methylation-in-menopause-and-strategies-for-improvement/) - For practitioners, balancing hormones at the point of menopause is challenging, even without complications from methylation. Methylation is involved in countless processes in the body, so it should be unsurprising that menopause and imbalanced methylation impact each other and worsen symptoms. Separating methylation and menopause symptoms and tracking the root cause is challenging because of
- [Timing Hormone Replacement Therapy for Maximum Benefit](https://plminstitute.org/plmi-blog/timing-hormone-replacement-therapy-for-maximum-benefit/) - Human females are particularly attuned to cycles, with monthly cycles of hormones that allow fertility or, with the hormone’s dearth, prevent fertility. It should be unsurprising that adding exogenous hormones at particular points in a woman’s cycle could result in health benefits, especially at menopause, when menstrual cycles wane and eventually cease as a natural
- [The Impact of Hormone Replacement Therapy on the Gut Microbiome](https://plminstitute.org/plmi-blog/the-impact-of-hormone-replacement-therapy-on-the-gut-microbiome/) - Similarly to sex hormones, the gut microbiome and its agents act upon remote tissues in a finely coordinated dance of spheres of influence. When both elements influence each other, a variety of permutations ensue. There can be a significant similarity in symptoms between menopause and an imbalanced gut flora (as evidenced by the makeup of
- [Collagen in Women’s Health: Beyond Healthy Skin](https://plminstitute.org/plmi-blog/collagen-in-womens-health-beyond-healthy-skin/) - Collagen supplementation has grown in popularity over recent years for claims of the reported anti-aging benefits of ingesting collagen peptides (1).A 2019 review of randomized-controlled trials (RCTs) using oral collagen supplementation to improve the quality and integrity of damaged skin found 11 valid studies with 805 human patients. Combined study results were promising for the
- [Functionality of Collagen Over the Women’s Health Continuum](https://plminstitute.org/plmi-blog/functionality-of-collagen-over-the-womens-health-continuum/) - Sources: Collagens. Cell Tissue Res. 2010 Jan;339(1):247-57. doi: 10.1007/s00441-009-0844-4. Epub 2009 Aug 20. PMID: 19693541; PMCID: PMC2997103. Gelse K, Pöschl E, Aigner T. Collagens–structure, function, and biosynthesis. Adv Drug Deliv Rev. 2003 Nov 28;55(12):1531-46. doi: 10.1016/j.addr.2003.08.002. PMID: 14623400. Gordon MK, Hahn RA. Collagens. Cell Tissue Res. 2010 Jan;339(1):247-57. doi: 10.1007/s00441-009-0844-4. Epub 2009 Aug 20. PMID:
- [Sleep Physiology and the Gut-Immune-Brain Network](https://plminstitute.org/plmi-blog/sleep-physiology-and-the-gut-immune-brain-network/) - Sleep is vital to optimal wellness, providing energy, alertness, improved health, steadier blood sugar levels, a better functioning immune system, and the list goes on. Yet, healthcare providers frequently receive patient complaints about insufficient sleep, making individuals more anxious and prone to significant health problems. Chronic sleep disturbance dramatically impacts a person’s quality of life,
- [Exploring the Role of Stress in IBS and the 3 Specialty Tests That Can Help Personalized Treatment](https://plminstitute.org/hot-topics/health-fitness/exploring-the-role-of-stress-in-ibs-and-the-3-specialty-tests-that-can-help-personalized-treatment/) - Dr. Jerrica Sweetnich ND The complex relationship between stress and irritable bowel syndrome (IBS) has long been a subject of scientific investigation and clinical interest. IBS is a condition that affects 5-10% of the worldwide population. While the exact cause of IBS remains elusive, it is increasingly evident that stress plays a significant role in its
- [Cultivated meat to enter US market with full USDA approval](https://plminstitute.org/hot-topics/technology/cultivated-meat-to-enter-us-market-with-full-usda-approval/) - Megan Poinski Cultivated meat has received final approval to enter the U.S. market, as the USDA has issued grants of inspection to Upside Foods and Eat Just’s Good Meat. Both companies, based in California, will debut their cell-cultivated chicken products at restaurants run by famed chefs: Dominique Crenn will serve Upside Foods’ chicken at Bar
- [Benefits of Melatonin and How to Increase Melatonin Production](https://plminstitute.org/hot-topics/health-fitness/benefits-of-melatonin-and-how-to-increase-melatonin-production/) - Written by Jennifer McClinton — Melatonin is often thought of for sleep and preventing sleep disorders, but research shows that this natural hormone may also have other beneficial effects on our bodies. Melatonin is naturally produced in our pineal gland. The pineal gland is located in the center of our brains and its main function
- [How the FDA’s new clinical trials guidance affect supplements brands](https://plminstitute.org/hot-topics/health-fitness/how-the-fdas-new-clinical-trials-guidance-affect-supplements-brands/) - The U.S. Food and Drug Administration is advancing the use of decentralized clinical trials—a system in which some or all of the trial-related activities occur at locations other than traditional clinical trial sites—according to a press release and draft industry guidance issued in May. This news comes on the heels of the Federal Trade Commission’s December 2022 updated Health Products
- [Roundup: AI for predicting Alzheimer’s risk, training staff and more briefs](https://plminstitute.org/hot-topics/technology/roundup-ai-for-predicting-alzheimers-risk-training-staff-and-more-briefs/) - By Adam Ang HKUST-led study combines AI, genetic info to predict Alzheimer’s risk A research team led by the Hong Kong University of Science and Technology has made an AI model that uses genetic information to predict the risk of developing Alzheimer’s disease before the onset of symptoms. The team, which includes researchers from Shenzhen Institute of Advanced
- [New Food Order: Food companies must step up to mitigate climate change](https://plminstitute.org/hot-topics/planetary-health/new-food-order-food-companies-must-step-up-to-mitigate-climate-change/) - Dawn Reiss Corporations across the globe are pledging to become carbon neutral. More than 20% of companies in the world now have science-based target initiatives, according to Science Based Targets. But is it even enough? Food systems—both agriculture and food production—contribute to over a third of the world’s greenhouse gas emissions, according to the United Nations. Much comes
- [California begins groundbreaking effort to define regenerative agriculture](https://plminstitute.org/hot-topics/planetary-health/california-begins-groundbreaking-effort-to-define-regenerative-agriculture/) - Douglas Brown The state of California is in the beginning stages of a months-long campaign to develop a definition for the term regenerative agriculture, an effort that could yield a common way of understanding it, at least among California officials, by the end of the year. The endeavor seems simple enough: codifying a vague term
- [Here’s what a lab-grown burger tastes like](https://plminstitute.org/hot-topics/planetary-health/heres-what-a-lab-grown-burger-tastes-like/) - By Casey Crownhart Sitting in a booth in a hotel lobby in Brooklyn, I stared down the lineup of sliders, each on a separate bamboo plate. On the far left was a plant-based burger from Impossible Foods. On the right, an old-fashioned beef burger.And in the middle, the star of the show: a burger made with
- [Walmart, Simple HealthKit partner to offer at-home testing](https://plminstitute.org/hot-topics/personalized-medicine/walmart-simple-healthkit-partner-to-offer-at-home-testing/) - By Jessica Hagen California-based diagnostics startup Simple HealthKit announced that it is partnering with Walmart to make its home diagnostic test kits for diabetes, sexual wellness and respiratory health available to customers via the retail chain’s website. Simple HeathKit’s sexual health test kit can identify gonorrhea, chlamydia and trichomoniasis. Its respiratory test can detect influenza and respiratory syncytial virus (RSV),
- [Why tiny viruses could be our best bet against antimicrobial resistance](https://plminstitute.org/hot-topics/immune-health/why-tiny-viruses-could-be-our-best-bet-against-antimicrobial-resistance/) - By: Jessica Hamzelou Regular readers will know that the microbiome is one of my favorite topics to cover. The billions of bacteria crawling all over our bodies play a vital role in our health, influencing everything from digestion to immune health and even our moods. But there’s something else that makes a home inside us. Bacteriophages—or phages
- [Best Pregnancy Supplements for a Healthy Pregnancy](https://plminstitute.org/hot-topics/health-fitness/best-pregnancy-supplements-for-a-healthy-pregnancy/) - By: Laura Dan, BSc, NDTR Pregnancy presents many unique challenges ranging from increased nutritional requirements to nausea and vomiting. Certain supplements may be useful for addressing your pregnant patients’ needs during this monumental time. (6) Read on to discover the best pregnancy supplements to support and improve outcomes for your pregnant patients. Continue Reading
- [Supplement Ingredients — Probiotics for Women’s Health](https://plminstitute.org/hot-topics/health-fitness/supplement-ingredients-probiotics-for-womens-health/) - Written by Kim Erickson You’ve likely heard of probiotics—those beneficial microbes credited with supporting a healthy gut. But, while probiotics can be good for many, they are especially helpful for women because females tend to be affected by digestive problems more often than their male counterparts. For instance, did you know that women are two to six
- [Top Evidence-Based Herb and Supplements For Heart Health](https://plminstitute.org/hot-topics/personalized-medicine/top-evidence-based-herb-and-supplements-for-heart-health/) - by: Dr. Jaime Cloyd ND Cardiovascular disease kills one person every 34 seconds in the United States. Heart disease, one type of cardiovascular disease, is the leading cause of death in the United States and accounts for $229 billion in annual healthcare costs. You cannot afford to ignore cardiovascular disease. Fortunately, many cardiovascular disease risk factors
- [4 Lab Test That Can Help You Explore the Connection Between Inflammation and Your Patients Metabolic Health](https://plminstitute.org/hot-topics/personalized-medicine/4-lab-test-that-can-help-you-explore-the-connection-between-inflammation-and-your-patients-metabolic-health/) - by Lauren Ann Chaunt CNS, LCSW There’s a growing body of evidence suggesting there is a complex interplay between inflammation and metabolic health. These are concerning issues today, as inflammation has been suggested to drive several conditions that collectively represent leading causes of disability worldwide, including poor metabolic health, affecting a third of all adults. Continue
- [The Role of Endogenous Sex Hormones in the Development of Type 2 Diabetes](https://plminstitute.org/hot-topics/health-fitness/the-role-of-endogenous-sex-hormones-in-the-development-of-type-2-diabetes/) - Hormonal balance is recognized as a factor in the development of non-communicable diseases, such as type 2 diabetes. The topic is of particular interest regarding the health of peri- and post-menopausal women who experience changes in hormone levels during the menopausal transition and also have increased risk of developing non-communicable diseases, such as cardiovascular disease
- [Michelle Obama launches healthier food and beverage company](https://plminstitute.org/hot-topics/health-fitness/michelle-obama-launches-healthier-food-and-beverage-company/) - Christopher Doering, Senior Reporter Former first lady Michelle Obama is co-founding Plezi Nutrition, a company focused on healthier food and beverage products for elementary school-aged children. Obama announced the endeavor on Wednesday at The Wall Street Journal‘s Future of Everything Festival. The brand’s first product is a beverage, also called Plezi, that has 75% less
- [Healthy.io raises $50M to expand smartphone kidney test in U.S.](https://plminstitute.org/hot-topics/technology/healthy-io-raises-50m-to-expand-smartphone-kidney-test-in-u-s/) - Smartphone urinalysis company Healthy.io announced Wednesday it had wrapped up a $50 million funding round. The Series D, which also includes a previously unannounced $45 million raise from early last year, was led by Schusterman Family Investments, with participation from Aleph and existing investors. Healthy.io said the funds will be used to expand in the U.S. The
- [How bugs and chemicals in your poo could give away exactly what you’ve eaten](https://plminstitute.org/hot-topics/microbiome/how-bugs-and-chemicals-in-your-poo-could-give-away-exactly-what-youve-eaten/) - By Jessica Hamzelou Yes, our waste contains the stuff that our bodies are generally trying to get rid of. But it can also provide insight into our gut microbiomes and how they influence our health. And we’re getting closer to understanding the impact of individual foods. The gut microbiome is the name we give to
- [New Food Order: Defining and Scaling Regenerative Agriculture](https://plminstitute.org/hot-topics/planetary-health/new-food-order-defining-and-scaling-regenerative-agriculture/) - By Dawn Reiss Regenerative agriculture is more important than ever. As the food industry moves into more sustainable practices to mitigate climate change, implementing regenerative practices to build more resilient ecosystems has become a burgeoning trend. It’s about renewing the land, by farming, ranching and creating a food system in a holistic manner within nature.
- [What is Intuitive Eating: Principles, Benefits, and More](https://plminstitute.org/hot-topics/health-fitness/what-is-intuitive-eating-principles-benefits-and-more/) - Written by Jayelah Bush, BScN As babies, we’re all intuitive eaters. Babies cry when they feel hungry and eat until they’re full. As we age, feelings and rules placed around food start to govern our choices. We often learn that we have to finish everything on our plate and that dessert is a reward for
- [Is Toxic Burden the Root Cause of Your Food Sensitivities?](https://plminstitute.org/hot-topics/epigenetics/is-toxic-burden-the-root-cause-of-your-food-sensitivities/) - by Greer McGuinness MS, RD, CDN, CLT, Dt. Sp, CMH The Environmental Protection Agency (EPA) estimates that roughly 84,000 chemical substances are in use in the US —many of which have limited testing for their effects on humans and the environment. Americans are exposed to many of these toxins daily, from everyday personal care items
- [Types of Exercise and Their Health Benefits](https://plminstitute.org/hot-topics/health-fitness/types-of-exercise-and-their-health-benefits/) - Written by Laura Dan, BSc, NDTR Exercise is defined as a type of movement that is intentional, structured, and habitual. (6) There are four different types of exercise – aerobic, strength, flexibility, and stability. The health benefits of exercise are broad and include improving mental, cardiovascular, and structural well-being. Research has also shown that regular
- [A test told me my brain and liver are older than they should be. Should I be worried?](https://plminstitute.org/hot-topics/technology/a-test-told-me-my-brain-and-liver-are-older-than-they-should-be-should-i-be-worried/) - By Jessica Hamzelou It’s spring here in the Northern Hemisphere. There are daffodils, tulips, and hyacinths in full bloom in parks and window boxes where I live in London. I even saw some lambs on the weekend. But here I am, thinking about how close I am to death. Last year, I took a test
- [Bacteria can be engineered to fight cancer in mice. Human trials are coming.](https://plminstitute.org/hot-topics/microbiome/bacteria-can-be-engineered-to-fight-cancer-in-mice-human-trials-are-coming/) - By Jessica Hamzelou There are trillions of microbes living in and on our bodies—and we might be able to modify them to help us treat diseases. Scientists have altered the genomes of some of these bacteria that live on skin, essentially engineering microbes that can prevent or treat cancer. It appears to work in mice,
- [Google to offer limited access to medical LLM](https://plminstitute.org/hot-topics/health-fitness/google-to-offer-limited-access-to-medical-llm/) - By Jessica Hagen Google has announced that Med-PaLM 2, the tech giant’s medical large language model, will be available to select Google Cloud customers in the coming weeks to share feedback, explore use cases and for limited testing. Med-PaLM 2 is a generative AI technology that utilizes Google’s LLMs to answer medical questions. When tested on
- [Hot Flashes: Why They Happen and How to Stop Them](https://plminstitute.org/hot-topics/health-fitness/hot-flashes-why-they-happen-and-how-to-stop-them/) - By Monazza Ahmad, B.Pharm, MSc One of the symptoms of menopause that women wish had a permanent cure is hot flashes! The most uncomfortable and rather embarrassing aspect of hot flashes is that they visit unexpectedly. It doesn’t matter if you’re in a work meeting with executives, teaching to kindergarteners, at an intimate dinner, or
- [New Food Order: What is the role of biotech in an ethical food system?](https://plminstitute.org/hot-topics/technology/new-food-order-what-is-the-role-of-biotech-in-an-ethical-food-system/) - Cultivated meat—also called cultured meat, cell-based or lab-grown meat—is a bourgeoning industry. Billions in investment dollars are being spent now, and the McKinsey Institute estimates making cultivated meat will become a $25 billion global industry by 2030. Regardless of what it is called, biotechnology and cellular agriculture is impacting the food system in ways never
- [How Do You Make a Water Purifier From Fruit Waste?](https://plminstitute.org/hot-topics/technology/how-do-you-make-a-water-purifier-from-fruit-waste/) - Article By: Karen Steward PhD Singapore scientists have demonstrated that fruit peels can be used to purify water, an innovation that can be employed in remote areas and disaster zones where electricity access is limited. The Nanotech team, led by Assistant Professor Edison Ang, based at Natural Sciences and Science Education, National Institute of Education
- [Your skin microbiome may influence the wrinkles you develop with age](https://plminstitute.org/hot-topics/microbiome/your-skin-microbiome-may-influence-the-wrinkles-you-develop-with-age/) - By David Cox Certain bacteria have been linked with a loss of collagen, the protein that gives youthful skin a smooth appearance. Better understanding the role of these bacteria in wrinkles and skin sagging could lead to new anti-ageing treatments From our mid-20s onwards, our skin progressively loses its elasticity and plumpness, leading to wrinkles
- [A path towards personalized medicine for autoinflammatory and related diseases](https://plminstitute.org/hot-topics/personalized-medicine/a-path-towards-personalized-medicine-for-autoinflammatory-and-related-diseases/) - The human genome project led to the advancement of genetic technologies and genomic medicine for a variety of human diseases, including monogenic autoimmune and autoinflammatory diseases. As a result, the genome of an individual can now be rapidly sequenced at a low cost, and this technology is beginning to change the practice of rheumatology. In
- [Gut Microbiome-Trained T Cells Help Heal Injured Muscles and Liver](https://plminstitute.org/hot-topics/microbiome/gut-microbiome-trained-t-cells-help-heal-injured-muscles-and-liver/) - Studies in mice by Harvard Medical School (HMS) researchers suggest how a class of regulatory T cells (Tregs) that are produced in the gut also play a role in repairing injured muscles and mending damaged livers. The research found that gut microbiota fuel the production of, and act as the training camp for, a class
- [Gut Microbiomes Offer Insights into Chronic Fatigue Syndrome](https://plminstitute.org/hot-topics/microbiome/gut-microbiomes-offer-insights-into-chronic-fatigue-syndrome/) - By: Shafaq Zia Millions of people are affected by the debilitating exhaustion and brain fog that characterizes the long-term condition chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis. Although CFS has been connected to viral infections including COVID-19, the underlying cause of the disease remains unknown. Now, a study led by researchers at Columbia
- [A New Connection: Gut Bacteria May Play a Role in Diabetes](https://plminstitute.org/hot-topics/microbiome/a-new-connection-gut-bacteria-may-play-a-role-in-diabetes/) - By Cedars-Sinai An ongoing study led by Cedars-Sinai has demonstrated that certain gut bacteria may increase the risk of Type 2 diabetes while others may provide protection against it. These are early results from a prospective study. According to the study, which was published in the journal Diabetes, higher levels of the bacterium Coprococcus are
- [Skipping Breakfast May Compromise the Immune System](https://plminstitute.org/hot-topics/immune-health/skipping-breakfast-may-compromise-the-immune-system/) - By: Filip Swirski, PhD New York, NY (February 23, 2023) — Fasting may be detrimental to fighting off infection, and could lead to an increased risk of heart disease, according to a new study by the Icahn School of Medicine at Mount Sinai. The research, which focused on mouse models, is among the first to
- [Integrating digital health apps into clinical care](https://plminstitute.org/hot-topics/technology/integrating-digital-health-apps-into-clinical-care/) - By: Emily Holsen After nearly 25 years at Kaiser Permanente, Trina Histon recently took on a new challenge at Woebot Health, the company behind a chatbot for mental healthcare. Histon’s new role as vice president of clinical product strategy will focus on integrating Woebot into clinical care. She previously spent several years at Kaiser developing
- [Afternoon Workouts May Yield the Most Benefits for Longevity](https://plminstitute.org/hot-topics/health-fitness/afternoon-workouts-may-yield-the-most-benefits-for-longevity/) - By Becky Upham Although exercise at any time has benefits, a new study has found that a midday workout is linked to a lower risk of death from heart disease and cancer. If you exercise at lunchtime, there may be moments — possibly when you’re unpacking the sweaty clothes from your gym bag each evening —
- [How CRISPR could help save crops from devastation caused by pests](https://plminstitute.org/hot-topics/planetary-health/how-crispr-could-help-save-crops-from-devastation-caused-by-pests/) - By: Emma Foehringer Merchant Gene editing insects could help reduce reliance on pesticides—and help protect billion-dollar industries. Central California grape-grower Steve McIntyre was familiar with Pierce’s Disease. But that did not prepare him for what he saw when he visited his brother’s Southern California citrus and avocado farm in 1998. The disease, which causes vines
- [Study identifies a previously unknown role of ‘natural killer’ immune cells](https://plminstitute.org/hot-topics/immune-health/study-identifies-a-previously-unknown-role-of-natural-killer-immune-cells/) - Melbourne researchers have improved our understanding of how the immune system is regulated to prevent disease, identifying a previously unknown role of ‘natural killer’ (NK) immune cells. The Monash University-led study identified a new group of immune cells, known as tissue-resident memory natural killer (NKRM) cells. NKRM cells limited immune responses in tissues and prevented

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## Premium Events

- [Creating Successful Patient Healing Journeys: Restoring Connection, Finding Hope and Evolving Wellness](https://plminstitute.org/premium-event/creating-successful-patient-healing-journeys-restoring-connection-finding-hope-and-evolving-wellness/) - Each patient brings their own unique background, experience, and beliefs about their illness to the discussion with their health practitioner. What has become clear is that the success of the outcome from therapy provided by the practitioner is partly dependent on the nature of the communication established between the patient and practitioner. The success of

## Histories

- [2013 - PLMI Publishes Landmark Article](https://plminstitute.org/history/2013-plmi-publishes-landmark-article/) - Personalized Lifestyle Medicine did not yet have a formal definition or an identity in the medical literature.
- [2021 - PLMI Expands Online Events](https://plminstitute.org/history/2021-plmi-expands-online-events/) - We have entered a pandemic era and this fact has changed the world.
- [2018 - PLMI Leadership Council Established](https://plminstitute.org/history/2018-plmi-leadership-council-established/) - Advocacy is an important part of PLMI's mission.
- [2015 - Thought Leaders Consortium in the Spotlight](https://plminstitute.org/history/2015-thought-leaders-consortium-in-the-spotlight/) - The Thought Leaders Consortium has become PLMI’s signature annual event.
- [2012 - PLMI Founded](https://plminstitute.org/history/2012-plmi-founded/) - This intersection of personalized medicine lifestyle, and patient-activated health care.

## Events

- [Build Your Brand Blueprint Workshop](https://plminstitute.org/events/build-your-brand-blueprint-workshop/) - Course Description: Build a brand that reflects your expertise, attracts the right audience, and amplifies your impact. In this comprehensive workshop series, you’ll develop the foundational elements of a powerful personal brand, including your trusted authority, brand essence, mission and values, ideal client psychographics, storytelling strategy, purpose, market positioning, and business assets. Through expert-led training
- [Food as Medicine Made Real: What the Largest Trial of a Single Whole Food Means for the Future of Healthcare](https://plminstitute.org/events/food-as-medicine-made-real-what-the-largest-trial-of-a-single-whole-food-means-for-the-future-of-healthcare/) - Plus, nutrition in action! Holiday cooking and health-focused recipes with Dr. Bland and his granddaughter Taylor Bland Program Overview Food has long been recognized as one of the most powerful influences on human health, yet translating that knowledge into precise, evidence-based clinical recommendations has remained a challenge. Emerging advances in metabolomics, epigenetics, immune biology, and
- [Decoding the Immune System: Tolerance, Triggers, and Targeted Care](https://plminstitute.org/events/decoding-the-immune-system-tolerance-triggers-and-targeted-care-2/) - Course Description Decoding the Immune System is a comprehensive, clinically focused educational series designed for practitioners seeking a deeper, more precise understanding of immune function, immune dysregulation, and autoimmune progression. Developed in collaboration with PLMI and executive partner Cyrex Laboratories, this course bridges foundational immunology with real-world clinical application. Through a systems-based lens, participants will
- [Advanced Bloodlabs and Interpretations for Immunometabolic and Hormonal Health](https://plminstitute.org/events/advanced-bloodlabs-and-interpretations-for-immunometabolic-and-hormonal-health/) - Overarching Description: Modern laboratory testing offers far more than isolated data points—it provides a window into the interconnected systems that drive health, resilience, and chronic disease risk. In this five-part advanced series, leading experts Dr. Lara Zakaria and Dr. Carrie Jones explore the latest science and clinical application of nutrient status, inflammation, thyroid physiology, cardiometabolic
- [From Insight to Implementation: Using Immunometabolic Biomarkers to Assess, Personalize, and Scale Patient Care](https://plminstitute.org/events/from-insight-to-implementation-using-immunometabolic-biomarkers-to-assess-personalize-and-scale-patient-care/) - Course Description Chronic disease is increasingly driven by underlying immunometabolic dysfunction, yet many clinicians lack practical tools to identify these processes early and translate findings into meaningful clinical action. This webinar explores the science and clinical utility of inflammatory and immunometabolic biomarkers, including emerging applications of the Systemic Immune-Inflammation Index (SII) and Systemic Inflammation Response
- [“Voices at the Table: A Kids-Led Conversation on Food”](https://plminstitute.org/events/voices-at-the-table-a-kids-led-conversation-on-food/) - Adults make most food decisions for children—but children live with those decisions every single day. What happens when we invite kids into the conversation? In this refreshing and insight-rich talk, The Holistic Kids—authors of The Teen Health Revolution—offer adults something rarely heard: honest, lived insight into what truly helps kids eat better… and what unintentionally
- [Infrared Insights: Unlocking the Science of Light Therapy for Healthspan and Lifespan](https://plminstitute.org/events/infrared-insights-unlocking-the-science-of-light-therapy-for-healthspan-and-lifespan-2/) - Join us for an in-depth, three-part course designed to provide a deeper understanding of the biological impact and application of infrared light therapy to help improve healthspan and lifespan. This course, offered by the Personalized Lifestyle Medicine Institute, brings together leading experts to explore the science of infrared light and heat that can positively impact
- [14th Annual Thought Leaders Consortium](https://plminstitute.org/events/2026-14th-annual-thought-leaders-consortium/) - Mitochondrial Vitality: The Foundation of Immuno-Metabolic Resilience, Longevity, and Clinical TransformationThe 14th Annual Thought Leaders Consortium marks the culminating chapter of PLMI’s three-year exploration into the biology of immuno-metabolism, epigenetic regulation, and human longevity. Building on the 2024 and 2025 Consortia—which reframed chronic disease through immune-metabolic dysfunction and diet- and environment-driven epigenetic remodeling—this year’s gathering
- [2027 Clinical Mastery Conference Presale](https://plminstitute.org/events/2027-clinical-mastery-conference-presale/) - Secure your spot early for our 2027 event to take advantage of preferred pricing and ensure availability.
- [Mitochondria Through the Lens of the Gut-Heart-Brain Axis](https://plminstitute.org/events/mitochondria-through-the-lens-of-the-gut-heart-brain-axis-2/) - Building upon the foundational concepts introduced in the virtual event, this Deep Dive Series expands into a more detailed and clinically focused exploration of mitochondrial health through the interconnected lens of the Gut-Heart-Brain Axis. This advanced series is designed to translate systems biology into practical, patient-centered applications across key stages of life and clinical presentations.
- [Applied Nutrigenomics Bootcamp: Mastering Clinical Translation from Basics to Biomarkers](https://plminstitute.org/events/applied-nutrigenomics-bootcamp-mastering-clinical-translation-from-basics-to-biomarkers/) - Course Description This immersive bootcamp is designed to equip clinicians with the foundational science and advanced clinical application skills required to confidently integrate nutrigenomics into everyday practice. Moving from core genetic principles to biomarker correlation and case-based translation, this program bridges the gap between genomic theory and precision clinical implementation. Through a systems biology and
- [Beyond Genetics: DNA Methylation, Epigenetic Clocks, and Biomarkers for Real-World Care](https://plminstitute.org/events/beyond-genetics-dna-methylation-epigenetic-clocks-and-biomarkers-for-real-world-care/) - 5x pre-recorded videos with Dr. Loren Clarke; approximately 45 mins each Module 1: Genetics 101 — DNA → RNA → Protein (quick refresher) Module 2: Epigenetics 101 — gene regulation and methylation basics Module 3: TruD Biological Clocks — what they are and what they measure Module 4: Building the Clocks — how epigenetic clocks
- [Advancing Hormone Assessment in Perimenopause and Menopause: Moving Beyond Symptoms to Longitudinal Monitoring](https://plminstitute.org/events/advancing-hormone-assessment-in-perimenopause-and-menopause-moving-beyond-symptoms-to-longitudinal-monitoring/) - This two-part clinical program presents an evidence-informed approach to advancing hormone assessment in perimenopause and menopause, moving beyond symptom-based evaluation and single timepoint serum testing toward longitudinal hormone monitoring. In Part 1, Dr. Carrie Jones (ND, FABNE, MPH, MSCP) examines the limitations of conventional assessment strategies and introduces a framework for incorporating serial hormone data
- [The Gut-Bone Axis in Midlife Women: Inflammation, Bone Health, and Emerging Clinical Solutions](https://plminstitute.org/events/the-gut-bone-axis-in-midlife-women-inflammation-bone-health-and-emerging-clinical-solutions/) - Midlife is a pivotal time for women’s health, with shifts in hormones, inflammation, and gut function influencing bone health in important ways. This two-hour webinar brings together Felice Gersh, MD and Mark Charbonneau, PhD, moderated by Bridgette Briggs, MD, for an expert discussion on the gut-bone axis and its relevance to women in midlife. Through
- [From Macros to Micros: How to Make the Most of Your Nutritional Assessment](https://plminstitute.org/events/from-macros-to-micros-how-to-make-the-most-of-your-nutritional-assessment/) - This PLMI virtual educational program offers an in-depth, clinically focused examination of nutritional assessment as a foundational tool in personalized and functional healthcare. The session will explore the integration of macronutrient intake analysis with micronutrient status, functional biomarkers, and clinical context to support more precise nutrition-based decision-making. Moderated by Deanna Minich, PhD, and featuring Dr.
- [Decoding Healthspan: Integrating Genetic Insights for Inflammaging — From Hormones to Gut Health](https://plminstitute.org/events/decoding-healthspan-integrating-genetic-insights-for-inflammaging-from-hormones-to-gut-health/) - Course Description This advanced educational program explores the clinical integration of genetic insights to better understand and address the biological drivers of inflammaging, oxidative stress, hormonal resilience, and gut integrity. Through a precision medicine lens, faculty will translate emerging genomic science into practical, patient-centered strategies that support healthy ageing and metabolic longevity. Participants will examine
- [Mitochondria Through the Lens of the Gut–Heart–Brain Axis](https://plminstitute.org/events/mitochondria-through-the-lens-of-the-gut-heart-brain-axis/) - Cardiovascular disease remains the leading cause of death for women in the United States, and the problem is projected to worsen in the coming decades. In a statement released February 25 by the American Heart Association, researchers reported concerning projections for women’s cardiovascular health. According to a review article published in Circulation, analysis of national
- [Redox Resilience: How Glutathione and Mitochondrial Function Shape Cardiovascular Risk](https://plminstitute.org/events/redox-resilience-how-glutathione-and-mitochondrial-function-shape-cardiovascular-risk/) - Oxidative stress and mitochondrial dysfunction are increasingly recognized as central drivers of cardiovascular disease, influencing endothelial function, inflammation, lipid oxidation, and metabolic resilience. At the core of these processes lies redox balance—particularly the role of glutathione as the body’s master antioxidant and its intimate relationship with mitochondrial health. This course explores the mechanistic links between
- [Health Intelligence: Improving Outcomes Through Wearables and Clinical Biometrics](https://plminstitute.org/events/health-intelligence-improving-outcomes-through-wearables-and-clinical-biometrics/) - Course Description In today’s era of precision and functional medicine, clinicians need more than isolated lab values to fully understand patient physiology. While traditional diagnostics offer a moment-in-time snapshot, true clinical clarity emerges from continuous, real-world data—revealing how a patient sleeps, recovers, responds to stressors, and adapts over time. PLMI, in collaboration with Biocanic, presents
- [Optimizing Women’s Health Across the Motherspan™: A Mitochondrial Approach](https://plminstitute.org/events/optimizing-womens-health-across-the-motherspan-a-mitochondrial-approach/) - Course Description Mitochondrial dysfunction is increasingly recognized as a central mechanistic driver of reproductive aging, subfertility, pregnancy complications, and the metabolic and hormonal transitions of perimenopause. As primary regulators of cellular energy production, redox balance, steroidogenesis, and apoptosis, mitochondria play a critical role in oocyte quality, placental development, and endocrine resilience across the female lifespan.
- [Decoding the Immune System: Tolerance, Triggers, and Targeted Care](https://plminstitute.org/events/decoding-the-immune-system-tolerance-triggers-and-targeted-care/) - Course Description Decoding the Immune System is a comprehensive, clinically focused educational series designed for practitioners seeking a deeper, more precise understanding of immune function, immune dysregulation, and autoimmune progression. Developed in collaboration with PLMI and executive partner Cyrex Laboratories, this course bridges foundational immunology with real-world clinical application. Through a systems-based lens, participants will
- [Clinical Mastery of Hormones: Integrating Metabolites, Metabolism, and Patient Patterns.](https://plminstitute.org/events/clinical-mastery-of-hormones-integrating-metabolites-metabolism-and-patient-patterns/) - As hormone therapy, metabolic dysregulation, and age-related concerns continue to rise, clinicians need a clear and science-grounded understanding of how hormones truly work. Yet, the current assessment model of measuring parent hormones in serum provides a view only into hormone production, and leaves out what happens when hormones interact with receptors at a tissue level.
- [The Annual PLMI Clinical Mastery Conference: The Keys to Brain Resilience and Recovery](https://plminstitute.org/events/the-annual-plmi-clinical-mastery-conference/) - Breakthrough Science is redefining how we understand and support brain health. Through our systems biology approach, researchers are uncovering strategies to prevent and reverse cognitive decline. These findings emphasize the vital role of brain resilience and recovery in sustaining lifelong vitality, optimal function and quality of life. Join our panel of leading experts — including
- [Stem Cells: The Cornerstone of Human Health](https://plminstitute.org/events/stem-cells-the-cornerstone-of-human-health/) - Adult stem cells play a critical role in the body’s natural repair and regeneration systems. Mobilized from the bone marrow into circulation in response to tissue injury and physiological stress, these cells support ongoing tissue maintenance and recovery. The number of circulating stem cells may therefore influence the body’s capacity for resilience, repair, and healthy
- [Advances in DNA Methylation Analysis: The New Frontier for Clinical Diagnostics](https://plminstitute.org/events/advances-in-dna-methylation-analysis-the-new-frontier-for-clinical-diagnostics/) - Technological breakthroughs in Omic technologies have led to a new wave of molecule biomarkers and clinical insights. Now, technology platforms from proteomics, metabolomics, and epigenomics are becoming tested as frequently as genetics and offering even more insight for clinicians to use for their patients. This growth is most prevalent in the field of epigenetic methylation.
- [Nitrates, Nitric Oxide, and their under-leveraged role in healthy female aging.](https://plminstitute.org/events/nitrates-nitric-oxide-and-their-under-leveraged-role-in-healthy-female-aging/) - By the age of 40, our bodies are making Nitric Oxide, a critical signaling molecule in cardiovascular health, at about 50% the levels made in our youth. For women, the journey from 40 to 60 holds additional significance as hormones fluctuate and bring about the significant transition into menopause. Dietary nitrates have been shown to
- [Unlocking the Power of Akkermansia: Healthy Weight and Blood Sugar Metabolism](https://plminstitute.org/events/unlocking-the-power-of-akkermansia-healthy-weight-and-blood-sugar-metabolism/) - Join us for an enlightening webinar featuring experts Drs. De Vos and Oubre as they delve into the fascinating world of Akkermansia, a promising next-generation bacteria and its transformative effects on blood sugar and weight management. This webinar is your key to understanding the latest research and unlocking the potential for optimal metabolic health for
- [Mental Health In Menopause. The Role of Hormone Optimization Part 1](https://plminstitute.org/events/mental-health-in-menopause-the-role-of-hormone-optimization-part-1/) - A November 6, 2023 cover article in Glamour magazine was entitled “1.3 Million Women Enter Menopause Each Year. We Have to Stop Ignoring Them”. This article describes the clinical challenge many women face as they transition through peri-menopause and menopause. One percent of women go through menopause by 40 and 5% are menopausal by 45.
- [Mental Health In Menopause. The Role of Hormone Optimization Part 2](https://plminstitute.org/events/mental-health-in-menopause-the-role-of-hormone-optimization-part-1-905/) - A November 6, 2023 cover article in Glamour magazine was entitled “1.3 Million Women Enter Menopause Each Year. We Have to Stop Ignoring Them”. This article describes the clinical challenge many women face as they transition through peri-menopause and menopause. One percent of women go through menopause by 40 and 5% are menopausal by 45.
- [Improving Vagus Nervous System Tone Therapeutic Gateway to the Immune-Nervous Supersystem](https://plminstitute.org/events/improving-vagus-nervous-system-tone-therapeutic-gateway-to-the-immune-nervous-supersystem/) - The Vagus Nerves exert a profound influence on the autonomic nervous system, which controls involuntary bodily functions such as heart rate, digestion, and respiratory rate. Specifically, the Vagus nerve is known to enable the parasympathetic nervous system, promoting a “rest and digest” response that counterbalances the sympathetic nervous system’s “fight or flight” mode. This activation
- ["Is It All In The Brain?!" Integrating Brain Retraining "Neuroplasticity" Approaches into Your Practice for Improved Patients Outcomes](https://plminstitute.org/events/is-it-all-in-the-brain-integrating-brain-retraining-neuroplasticity-approaches-into-your-practice-for-improved-patients-outcomes/) - Recently, brain retraining, neuroplasticity and so called “limbic retraining” has become a hot topic in medicine, with many health practitioners already incorporating these protocols for better outcomes. Find out about these latest cutting-edge interventions from the pioneers in the field, and how it can be incorporated into your health practice, improving the lives of your
- [Advances in the Management of Gastrointestinal Disorders: Upper and Lower GI Issues and their Relationship to the Microbiome Part One](https://plminstitute.org/events/advances-in-the-management-of-gastrointestinal-disorders-upper-and-lower-gi-issues-and-their-relationship-to-the-microbiome-part-one/) - The conversion of food to substances that support healthy metabolism is a complex process involving interaction among the digestive, nervous, endocrine, immune, hepatobiliary, and microbiome systems. This represents a quintessential example of network systems activity which is a foundational concept underlying the Functional Medicine model. Over the past decade considerable progress has been made in
- [Advances in the Management of Gastrointestinal Disorders: Upper and Lower GI Issues and their Relationship to the Microbiome Part Two](https://plminstitute.org/events/advances-in-the-management-of-gastrointestinal-disorders-upper-and-lower-gi-issues-and-their-relationship-to-the-microbiome-part-two/) - The conversion of food to substances that support healthy metabolism is a complex process involving interaction among the digestive, nervous, endocrine, immune, hepatobiliary, and microbiome systems. This represents a quintessential example of network systems activity which is a foundational concept underlying the Functional Medicine model. Over the past decade considerable progress has been made in
- [The Gateway to Healing: Uncovering the Intersection of the Oral Microbiome, Gut Health, and Chronic Disease](https://plminstitute.org/events/the-gateway-to-healing-uncovering-the-intersection-of-the-oral-microbiome-gut-health-and-chronic-disease/) - You’ve likely heard of (and treated) the gut microbiome – a vibrant community of organisms that, when in balance, play a role in maintaining overall health and well-being. But did you know there is a 45% overlap between the microbial communities living in the oral cavity and in the gut? Our oral microbiome plays a
- [Cyrex’ Systems Immunology Approach to Predictive Medicine](https://plminstitute.org/events/cyrex-systems-immunology-approach-to-predictive-medicine/) - For decades, the goal of the field of immunology has been to delineate detailed pictures of the processes involved in humoral- and cell-mediated immunity. Recently, a new field of study has emerged; this is the field of Systems Immunology, which incorporates all the various components of immunity fused into a comprehensible entity. As clinicians, we
- [The Endocrine Symphony – Evaluating and Supporting the Organs of Communication](https://plminstitute.org/events/the-endocrine-symphony-evaluating-and-supporting-the-organs-of-communication/) - Navigating the Endocrine Maze – Unravelling Dysfunction for Clinical Success Course Description: Of the many dynamic body systems that functional medicine supports and balances, the endocrine system can often be one of the trickiest. With so many feedback mechanisms and overlapping patient symptoms, it can sometimes seem like balancing a patient’s hormones is like
- [A Woman’s Cycle of Life: Maximizing Outcomes through Mira and Femmenessence](https://plminstitute.org/events/a-womans-cycle-of-life-maximizing-outcomes-through-mira-and-femmenessence/) - A woman’s life cycle is dynamic in multiple realms: physical, emotional, mental, and spiritual. Part of this flux is due to the waxing and waning of different hormones from the psychoneuroendocrine circuit, which includes the hypothalamus, pituitary, thyroid, adrenal, and ovarian (HPTAO) axis. Women are becoming increasingly aware of the intricacies of the monthly menstrual
- [Clinical Advances in the Assessment and Management of the Toxicity-Obesity Epidemic Syndemic](https://plminstitute.org/events/clinical-advances-in-the-assessment-and-management-of-the-toxicity-obesity-epidemic-syndemic/) - Over the past three decades we have witnessed an exponential increase in both the adverse metabolic impact of obesity and the exposure and accumulation of persistent organic pollutants (POPs), toxic metals, and endotoxicity. These problems couple together to create what has been termed a “syndemic” where two or more factors intersect to multiple the adverse
- [The Importance of Lifestyle Genetics in Healthy Aging:  Relevance of Genetics from Preconception Across the Lifespan](https://plminstitute.org/events/the-importance-of-lifestyle-genetics-in-healthy-aging-relevance-of-genetics-from-preconception-across-the-lifespan/) - This presentation provides the information you have been looking for in understanding how to use nutrigenomics as a guiding tool in the development of personalized lifestyle medicine intervention programs. The two faculty for this course are both acknowledged experts in genomic-focused health care and the clinical application of genetic analysis in the development of science-based
- [Cellular Medicine Approaches to Migraine Management](https://plminstitute.org/events/cellular-medicine-approaches-to-migraine-management/) - Migraines impacts billions globally, with a notably higher prevalence among females. The complex pathophysiology presents a unique opportunity to dive into various mechanisms that could potentially address this condition. While no single pathophysiological explanation fully captures the complexity, it is clear that noxious stimuli serve as the primary triggers for migraine attacks. This presentation aims
- [Infrared Insights: Unlocking the Science of Light Therapy for Healthspan and Lifespan](https://plminstitute.org/events/infrared-insights-unlocking-the-science-of-light-therapy-for-healthspan-and-lifespan/) - Join us for an in-depth, three-part course designed to provide a deeper understanding of the biological impact and application of infrared light therapy to help improve healthspan and lifespan. This course, offered by the Personalized Lifestyle Medicine Institute, brings together leading experts to explore the science of infrared light and heat that can positively impact
- [Updates on DNAm: What works to reverse aging from 75 treatments and why a single test might replace the need for all others](https://plminstitute.org/events/updates-on-dnam-what-works-to-reverse-aging-form-75-treatments-and-why-single-test-might-replace-the-need-for-all-others/) - DNA methylation based diagnostics have been expanding as a major focus of research and development in the last few years. Now, this research is finally hitting clinical practice in a major way. In this series, we will talk about the most recent updates and why this is important for the ways you manage your clinics
- [Immunonutrition for Healthspan: Nutritional Targets to Rejuvenate Immunity and Slow Cell Aging](https://plminstitute.org/events/immunonutrition-for-healthspan-nutritional-targets-to-rejuvenate-immunity-and-slow-cell-aging/) - Despite dramatic progress in prolonging lifespan in the 20th century, research tells us that progress in improving our healthspan – our years of enjoying quality health- has barely budged. Chronic and largely preventable diseases linked to impaired immune function and dysregulated metabolism create unsustainable pressure on our healthcare systems, national budgets and our chances of
- [LIVE Follow Up Discussion: Systems Immunology Approach to Predictive Medicine](https://plminstitute.org/events/live-follow-up-discussion-systems-immunology-approach-to-predictive-medicine/) - Description: For decades, the goal of the field of immunology has been to delineate detailed pictures of the processes involved in humoral- and cell-mediated immunity. Recently, a new field of study has emerged; this is the field of Systems Immunology, which incorporates all the various components of immunity fused into a comprehensible entity. As clinicians,
- [Clinical Mastery of Hormones: Integrating Metabolites, Metabolism, and Patient Patterns](https://plminstitute.org/events/clinical-mastery-of-hormones-integrating-metabolites-metabolism-and-patient-patterns-2/) - Course Description This course provides an in-depth exploration of hormone physiology, regulation, and clinical application, integrating systems biology, laboratory interpretation, and real-world case studies. Participants will learn how to assess, interpret, and apply hormone data with nuance, accounting for metabolism, stress physiology, and clinical outliers. Learning Objectives By the end of this course, participants will
- [Lifestyle Tools for Immunometabolic Health: Reprogramming Cellular Pathways for Longevity and Healthspan](https://plminstitute.org/events/lifestyle-tools-for-immunometabolic-health-reprogramming-cellular-pathways-for-longevity-and-healthspan/) - Course Description: Chronic disease is increasingly understood as a result of disrupted immunometabolic function—where inflammation, metabolic imbalance, and cellular dysfunction converge. Immunometabolism, an emerging field at the nexus of systems biology and lifestyle medicine, offers powerful insights into how nutrition and other targeted interventions can restore balance, enhance resilience, and extend healthspan. This thought-provoking course
- [13th Annual Thought Leaders Consortium: Clinical Advances in Personalized Lifestyle Medicine](https://plminstitute.org/events/13th-annual-thought-leaders-consortium/) - The Revolutionary Applications of AI, Biometrics, and Nutrigenomics to Disorders of ImmunometabolismAmerican and global health is at a crossroads. We face unprecedented rates of chronic, preventable diseases driven by lifestyle factors that are bankrupting nations and crippling our chances at health. But we also have access to powerful new tools that allow us to understand
- [Unraveling the Upstream Drivers of ASCVD: A Functional and Evolutionary Lens on Cardiometabolic Risk](https://plminstitute.org/events/unraveling-the-upstream-drivers-of-ascvd-a-functional-and-evolutionary-lens-on-cardiometabolic-risk/) - Join Dr. Jeffrey Bland, PhD, Erik Lundquist, MD and Chris Magryta, MD for an illuminating two-hour exploration into the pathophysiological and anthropological roots of the growing epidemic of atherosclerotic cardiovascular disease (ASCVD) and hyperlipidemia in the United States. The session opens with a 30-minute keynote by Dr. Bland, who sets the stage with a systems
- [Detoxification Mastery: Advanced Strategies for Environmental Toxin Elimination & Clinical Application” OR “Current Topics in Detoxification](https://plminstitute.org/events/detoxification-mastery-advanced-strategies-for-environmental-toxin-elimination-clinical-application-or-current-topics-in-detoxification/) - Detoxification is more than just liver support—it’s a multisystem, epigenetically influenced process that determines resilience against heavy metals, mold toxins, microplastics, and persistent pollutants. This comprehensive, expert-led course is designed for medical professionals seeking to deepen their understanding of the biological impact of environmental toxins and implement cutting-edge, evidence-based detoxification strategies in clinical practice. Participants
- [Modernizing Menstrual Health: Clinical Research, Precision Hormone Tracking & Validated Patient Outcomes](https://plminstitute.org/events/modernizing-menstrual-health-clinical-research-precision-hormone-tracking-validated-patient-outcomes/) - How can providers support their patients beyond fertility? Are dietary and lifestyle interventions truly effective in improving menstrual health and overall wellbeing? In this webinar, Dr. Thomas Bouchard (Researcher at the University of British Columbia), Alisa Vitti (Founder of FLO Living), and Rosemary MacKenzie (Clinical Manager at Mira) will explore how hormone monitoring throughout the
- [Revolutionizing Patient Care: AI and Epigenetics at the Forefront of Precision Medicine](https://plminstitute.org/events/revolutionizing-patient-care-ai-and-epigenetics-at-the-forefront-of-precision-medicine/) - Discover how the powerful synergy of Artificial Intelligence and Epigenetics is transforming healthcare by enabling the diagnosis of virtually any disease from just a few drops of blood. This innovative approach delivers unprecedented precision, providing insights equivalent to over $100,000 worth of conventional diagnostics at a fraction of the cost. Join us to explore how
- [Unlocking the Power of Vagus Nerve Stimulation: Real Cases, Real Results](https://plminstitute.org/events/unlocking-the-power-of-vagus-nerve-stimulation-real-cases-real-results/) - Step into the forefront of integrative healthcare with this dynamic and evidence-driven webinar on Vagus Nerve Stimulation (VNS). Designed for healthcare professionals, therapists, and wellness practitioners, this course reveals how VNS is revolutionizing treatment strategies across diverse clinical settings. Through compelling real-world case studies, you’ll explore how practitioners are harnessing the vagus nerve to drive
- [Understanding Hormonal Imbalances in Women: Symptoms, Health Impacts, and Integrative Approaches](https://plminstitute.org/events/understanding-hormonal-imbalances-in-women-symptoms-health-impacts-and-integrative-approaches/) - Overview: When hormones are out of balance, it can feel like everything is off—mood swings, poor sleep, cravings, and even digestion issues. But understanding what’s happening inside the body is the first step to feeling better. In this engaging presentation, Felice Gersh, MD & Malisa Carullo, ND will break down the key hormones that impact
- [The Master Antioxidant: A Deep Dive into Glutathione’s Role in Metabolism, Mitochondrial Support, and Brain Function](https://plminstitute.org/events/the-master-antioxidant-a-deep-dive-into-glutathiones-role-in-metabolism-mitochondrial-support-and-brain-function/) - Join us for a perceptive webinar on glutathione, your body’s powerful antioxidant and discover its amazing benefits. This session will explore several ways in which our Aurowellness Glutathione Transdermal Serum can: Enhance Metabolism: Discover how glutathione supports metabolic processes, helping to optimize energy production and overall cellular function. Improve Mitochondrial Health: Learn about glutathione’s role
- [Revive & Thrive: Harnessing Nitric Oxide to Reignite Hormonal Balance and Female Vitality](https://plminstitute.org/events/revive-thrive-harnessing-nitric-oxide-to-reignite-hormonal-balance-and-female-vitality/) - Course Description: Join the Personalized Lifestyle Medicine Institute (PLMI) for a transformative session on the cutting-edge role of nitric oxide in women’s health. “Revive & Thrive” explores how this powerful molecule is reshaping our understanding of hormonal balance, easing menopausal transitions, and enhancing sexual vitality in women. Kicking off with an illuminating keynote by PLMI
- [10th Annual Metabolic Mastery Conference: Navigating Clinical Advances in the Microbiome - Mitochondria-Brain Connection](https://plminstitute.org/events/10th-annual-metabolic-mastery-conference/) - The evolution of medicine has been characterized by the development of an organ-specific approach to disease diagnosis and treatment.
- [The Gut Mycobiome: A Central Figure in Health and Disease](https://plminstitute.org/events/the-gut-mycobiome-a-central-figure-in-health-and-disease/) - The mycobiome (fungi) is a small but very crucial component of the gut microbiome. Intestinal fungi such as Candida species and food-derived fungi regulate physiological and pathophysiological processes
- [Refining “Dysbiosis”: Using Big-Data Analysis and Novel Interventions](https://plminstitute.org/events/refining-dysbiosis-using-big-data-analysis-and-novel-interventions/) - Most of us clinicians are familiar with the concept of dysbiosis. While this term has been a mainstay of functional GI evaluations for a long time,
- [Clinical Advances in Genetic Analysis and Its Practical Application: DNA Core, Hormones and Mind](https://plminstitute.org/events/clinical-advances-in-genetic-analysis-and-its-practical-application-dna-core-hormones-and-mind/) - The field of genetic testing for personalized healthcare is growing exponentially. Keeping abreast of advances in technology, the literature, and understanding the clinical utility from research findings are all important aspects to consider when incorporating nutrigenetics as a valuable tool in practice. This webinar will discuss the clinical and scientific validity of the genes that
- [Clinical Updates in Menopausal Hormone Replacement Therapy: Optimizing Treatment and Hormone Monitoring](https://plminstitute.org/events/introduction-to-hormone-replacement-therapy/) - This webinar features expert presentations on Menopausal Hormone Replacement Therapy (MHRT) and hormone monitoring from Mark Newman, CEO of Precision Analytical, creators of the DUTCH Test, and Dr. Jaclyn Smeaton, ND and CMO of DUTCH. In Session 1, Dr. Smeaton will provide a clinically oriented overview of the latest research and guidelines for MHRT, with
- [Reversing Cognitive Decline at Scale](https://plminstitute.org/events/reversing-cognitive-decline-at-scale/) - Pioneers in Personalized Lifestyle Medicine have shown that reversing cognitive decline is possible, however the scale and access needed to actually impact the field have been delicate due to the complex nature of the disease, its varied root causes and patient demographic. This groundbreaking event will be hosted by PLMI Founder Dr. Jeffrey Bland to
- [Enhancing Bone Health: Exploring the Role of Synbiotic Therapy](https://plminstitute.org/events/enhancing-bone-health-exploring-the-role-of-synbiotic-therapy/) - Course Description: Explore cutting-edge research and innovative strategies for reducing bone loss with a focus on the gut-bone axis. In this webinar, leading experts Susan Bukata, MD, Chair of Orthopaedic Surgery, UCSD and Eric Schott, PhD, Co-Founder and COO of Solarea Bio, will discuss recent advancements in gut health and their implications for managing bone
- [12th Annual Thought Leaders Consortium: Advanced Course on Immuno-Metabolism](https://plminstitute.org/events/12th-annual-thought-leaders-consortium/) - Applications to Insulin Resistance, Sarcopenia, Muscle Weakness, Post-Viral Fatigue, Pre-Autoimmune, and Cognitive ImpairmentA major advance has been made in the clinical understanding of the relationship between alteration in immuno-metabolic function and chronic illness. The dysfunction in immuno-metabolic function connects to a wide range of clinical problems including, but not limited to, post-viral illness, sarcopenia and
- [Creating Successful Patient Healing Journeys: Restoring Connection, Finding Hope and Evolving Wellness](https://plminstitute.org/events/creating-successful-patient-healing-journeys-restoring-connection-finding-hope-and-evolving-wellness/) - Each patient brings their own unique background, experience, and beliefs about their illness to the discussion with their health practitioner. What has become clear is that the success of the outcome from therapy provided by the practitioner is partly dependent on the nature of the communication established between the patient and practitioner. The success of
- [Endocrine Typing: Connecting the Dots Between Toxin Load, Weight Loss Resistance, and Hormonal Dysfunction](https://plminstitute.org/events/endocrine-typing-connecting-the-dots-between-toxin-load-weight-loss-resistance-and-hormonal-dysfunction/) - The “Endocrine Typing: Connecting the Dots Between Toxin Load, Weight Loss Resistance, and Hormonal Dysfunction” conference is a premier event designed for health professionals, focusing on the intersection of endocrine function, obesity, type 2 diabetes and other metabolic disorders and their connection to diet, lifestyle and environmental factors. This conference boasts a stellar lineup of
- [Optimizing Menopause: Understanding the Role of Hormone Replacement Therapy and Natural Remedies for Symptom Relief and Long-Term Health Optimization](https://plminstitute.org/events/optimizing-menopause-understanding-the-role-of-hormone-replacement-therapy-and-natural-remedies-for-symptom-relief-and-long-term-health-optimization/) - Optimizing Menopause: Understanding the Role of HRT and Natural Remedies for Symptom Relief & Long-Term Health Optimization from PLMI on Vimeo. When you think about menopause, you may think about hot flashes, mood and libido changes, or other physical symptoms. But a comprehensive approach to menopause also manages risks to cardiovascular health, bone health, and
- [Long COVID: Living With-Living Beyond Regaining Hope](https://plminstitute.org/events/long-covid-living-with-living-beyond-regaining-hope/) - We have just been through a global trauma to body, mind and spirit called COVID-19. We are in the process of finding our way to recovery. In this process we have come to recognize that millions of people are suffering from what has been termed “Long COVID Syndrome.” This syndrome manifests itself in different ways
- [Cyrex Array 2 Intestinal Permeability Screen™ Deep Dive](https://plminstitute.org/events/cyrex-array-2-intestinal-permeability-screen-deep-dive/) - Do you treat patients struggling with Leaky Gut? Join Rupa Health’s 6-week deep dive using the Cyrex Array 2 to understand gut health, reduce the risk of autoimmunity, and support the intestinal immune system! This bootcamp is taught by the founder of functional medicine Dr. Jeffrey Bland in partnership with two of the leading experts
- [Cardiometabolic Function: The Intersection Among Neurology, Endocrinology, and Immunology](https://plminstitute.org/events/cardiometabolic-function-the-intersection-among-neurology-endocrinology-and-immunology/) - Cardiometabolic conditions may be the most identifiable, tested, and conventionally treated in medicine. Cardiometabolic risk (CMR) refers to risk factors that increase the likelihood of experiencing vascular events or developing diabetes. These conditions also pose the greatest risk of death, which is why they are a focus of conventional care. As functional medicine providers increase
- [Addressing Hormonal Imbalances in the Menstruating Female Using Natural Remedies](https://plminstitute.org/events/addressing-hormonal-imbalances-in-the-menstruating-female-using-natural-remedies/) - Addressing Hormonal Imbalances in the Menstruating Female Using Natural Remedies from PLMI on Vimeo. Hormonal imbalances can cause a wide range of symptoms for cycling women, such as irritability, breast sensitivity, headaches, and acne. Unfortunately, current treatment options available within the conventional healthcare model may or may not relieve symptomology and leave women feeling discouraged.
- [Exploring the Mechanisms of Action of Collagen Peptides over the Woman’s Health Continuum](https://plminstitute.org/events/exploring-the-mechanisms-of-action-of-collagen-peptides-over-the-womans-health-continuum/) - This expert-led webinar will identify the significance of collagen over a woman’s lifespan, identifying its functionality in pregnancy, postpartum and perimenopause. Physiologic and metabolic roles of endogenous collagen and its inherent amino acids will be elucidated, addressing collagen metabolism in younger life and collagen-related health concerns emerging in later years. Conditions closely associated with collagen
- [The Sleep-Gut-Brain Connection- A New Clinical Target](https://plminstitute.org/events/the-sleep-gut-brain-connection-a-new-clinical-target/) - Sponsored By: Mirobiome It is well recognized that individuals who suffer from sleep disturbances have altered composition of their intestinal microbiome. The question has been whether this relationship is coincidental or whether there is a physiological mechanism that connects these observations together in a systematic way that allows for a treatment of the primary cause
- [Treating ADHD with Nutrients, Herbs and More](https://plminstitute.org/events/treating-adhd-with-nutrients-herbs-and-more/) - [aiovg_video id=8602]Attention Deficit Hyperactivity Disorder (ADHD) affects an estimated 9-13% of kids and 8% of adults in the U.S. each year. There is an incredible amount of research that supports the effectiveness of both dietary and herbal interventions for improving ADHD symptoms like hyperactivity, impulsivity and more. In this talk we will teach you how
- [11th Annual Thought Leaders Consortium: Next Generation Clinical Management of Chronic Neuroimmune Disorders](https://plminstitute.org/events/tlc-2023-next-generation-clinical-management-of-chronic-neuroimmune-disorders-636/) - What is “pre-autoimmune disease”? You may be aware that this term has recently emerged in the medical literature to describe a concerning collection of neuroimmune symptoms that can vary in duration and intensity. To cut to the chase, pre-autoimmune disease is the next generation of disorders that will challenge health practitioners for years to come—an
- [Reduction in Immune System Aging: New Perspectives, New Opportunities](https://plminstitute.org/events/reduction-in-immune-system-aging-new-perspectives-new-opportunities/) - [aiovg_video id=11759] We are witnessing a virtual revolution in understanding of the epigenetics of immune aging and how this may connect to immune function and later stage disease and all cause mortality. This is potentially big news and a major paradigm shift in thinking about immune system function and the impact of diet, lifestyle and
- [The Exposome -Autoimmune Connection: Case Based Discussions](https://plminstitute.org/events/the-exposome-autoimmune-connection-case-based-discussions/) - The Exposome -Autoimmune Connection: Case Based Discussions from PLMI on Vimeo.The most challenging and possibly most crucial aspect of understanding autoimmunity is finding the root causes and early events that trigger what can be years of suffering. Environmental agents have been gaining more attention in recent years for their role in the pathogenesis of autoimmune
- [The Role of Microbiome in Immunity](https://plminstitute.org/events/the-role-of-microbiome-in-immunity/) - The Role of Microbiome in Immunity from PLMI on Vimeo.There is virtually no topic that has been more in the medical and general health consumer news recently than the discussion of the microbiome and the diversity of impacts it has on human health. The effects have ranged from obesity to diabetes to dementia, heart disease,
- [Advances in Gut-Brain Axis Support with a Special Focus Around IBS and Mental Health](https://plminstitute.org/events/advances-in-gut-brain-axis-support-with-a-special-focus-around-ibs-and-mental-health/) - It is virtually impossible to keep up with the rate of development of new information of clinical importance surrounding the gut-brain connection to functional alterations in mood, mental clarity and symptoms associated with the digestive system that has been termed the “second brain”. Fortunately this course leverages the expertise of two acknowledged world experts in
- [Mitochondrial Medicine: Exploring the Roots of Health and Disease](https://plminstitute.org/events/mitochondrial-medicine-exploring-the-roots-of-health-and-disease/) - This virtual conference will provide perspective on emerging paradigms of mitochondrial medicine and empower clinicians to address these key growing public health concerns, especially in regards to long-COVID, cardiometabolic health and chronic immune dysfunction.
- [Is COVID Long-Haul a disease of the gut](https://plminstitute.org/events/is-covid-long-haul-a-disease-of-the-gut/) - We are confronted with the reality that the legacy that is left behind from COVID-19 is a tremendous number of people suffering from long-term adverse symptoms that were triggered by the disease. It is has been estimated that more than 5% of the people who had COVID-19 including those with reasonably mild symptoms may suffer
- [The Microbiome: Connecting the Dots of Root Cause Medicine](https://plminstitute.org/events/the-microbiome-connecting-the-dots-of-root-cause-medicine/) - The importance of the microbiome as an integral facet of human health has gained immense traction over the last decade. From commensal microbes to gut pathogens to all the various aspects of health tied to microbiome balance to choosing your prebiotics, probiotics, and beyond. This seminar will put you at the head of your field—among
- [Reflections and Clinical Applications of the 2021 Thought Leaders Consortium](https://plminstitute.org/events/reflections-and-clinical-applications-of-the-2021-thought-leaders-consortium/) - The November 9,10 2021 Ninth Annual Thought Leaders Consortium was entitled “Immune Fitness: Healing and Optimizing Modern Immune Systems”. This was an amazing conference with a faculty of over 25 world renown leaders in both the basic science and clinical discoveries that have powered a dramatic increase in the understanding of the structure and function
- [Personalized Lifestyle Medicine Institute Presents “Pediatric Immune Resilience”](https://plminstitute.org/events/personalized-lifestyle-medicine-institute-presents-pediatric-immune-resilience/) - The past two years has focused attention on the importance of immune resilience. Many conferences have been held discussing immune issues in adults, but there has been a lack of similar focus on immune-related problems in children. This free-of-charge virtual educational program has three renown pediatric opinion leaders teaming with the Personalized Lifestyle Medicine Institute
- [New Approaches to Inflammation and Recovery: The Science of Collagen Peptides](https://plminstitute.org/events/new-approaches-to-inflammation-and-recovery-the-science-of-collagen-peptides/) - The science surrounding the clinical benefit of specific collagen peptides has been advancing rapidly over the past few years. This work has demonstrated that collagen peptides represent a new class of nutritional therapeutics that influence various clinical conditions. Historically collagen was thought of as exclusively a structural protein that makes us our connective tissue
- [The Burden of Food On Your Immune System](https://plminstitute.org/events/the-burden-of-food-on-your-immune-system/) - The immune system is constantly confronted with challenges ranging from infectious microorganisms, foreign proteins, xenobiotics, microbial metabolites, and food-derived immune reactive substances. Both the innate and adaptive immune systems are “programmed” by these exposures, and are epigenetically modified as a consequence of lifestyle, environment, and dietary factors. This virtual conference is focused on one of
- [Meaningful Differentiation, “Mind the Gap” When Monitoring Hormones in Peri Menopausal Women](https://plminstitute.org/events/meaningful-differentiation-mind-the-gap-when-monitoring-hormones-in-peri-menopausal-women/) - How do we know the functional status of the hormonal system? It is a much more complicated question than how to determine whether a patient has a specific hormonally related disease. The answer to understanding the function of the hormonal system lies in the use of specific functional endocrine tests and their interpretation. The accuracy,
- [Metagenomics, the Microbiome, and the Evolution of GI Evaluations](https://plminstitute.org/events/metagenomics-the-microbiome-and-the-evolution-of-gi-evaluations/) - Hippocrates is said to have stated that all diseases begin in the gut. In today’s clinical practices, gastrointestinal disorders represent a significant component of our patient's chronic diseases. It is rare when somebody comes in without some form of IBS. Given the complexities that lead to gut symptoms, it is invaluable to have a method
- [Harnessing Natures Wisdom for Immune Resilience: A Clinical Roadmap](https://plminstitute.org/events/harnessing-natures-wisdom-for-immune-resilience-a-clinical-roadmap/)
- [Epigenetic Age Testing and the Future Landscape of Epigenetic Diagnostics](https://plminstitute.org/events/epigenetic-age-testing-and-the-future-landscape-of-epigenetic-diagnostics/) - Being human means sharing several biological realities with every other individual on the planet—the need for sustenance and hydration, the rhythmic cycles of energy and rest, and the inevitability of aging, to name a few. Over the last decade, the science that guides us in decoding the patterns of healthspan has grown in scope and
- [Clinical Chronobiology: The Immune-Stress-Sleep Connection](https://plminstitute.org/events/clinical-chronobiology-the-immune-stress-sleep-connection/) - Description: We’ve all felt the stress of the past couple of years, and patients are more ready than ever to address it. As clinicians, we need to understand how our patients’ stress is uniquely affecting their health and help them to create and implement a personalized plan to manage it. In this presentation, we’ll go
- [Diving Deep into Gut, Brain, and Immune-related dysfunction using the Cyrex Array 2 Intestinal Antigenic Permeability Screen](https://plminstitute.org/events/diving-deep-into-gut-brain-and-immune-related-dysfunction-using-the-cyrex-array-2-intestinal-antigenic-permeability-screen/) - One of the body's most essential defense barriers is the intestinal barrier. When this barrier becomes permeated, the body often develops autoimmunity. Intestinal permeability can thus be a factor in various diseases, from food sensitivity to dermatologic conditions. For patients with multiple symptoms or a known autoimmune disease, analyzing intestinal permeability is an important step
- [Applying Clinician’s Wisdom: Managing Chronic Autoimmune Activation](https://plminstitute.org/events/applying-clinicians-wisdom-managing-chronic-autoimmune-activation/) - It has been thought that the immune system is designed to recognize self from non-self and mobilize a response to threat. The historical explanation of this process has resided in understanding the role of the innate and adaptive arms of the immune system. The routine clinical assessment of immune function has principally been through broad
- [Mastering the Implementation of Personalized Lifestyle Medicine: Advances in Clinical Functional Immunity](https://plminstitute.org/events/mastering-the-implementation-of-personalized-lifestyle-medicine-advances-in-clinical-functional-immunity/) - RECORDING - Advances in Clinical Immunity: Mastering the Implementation..
- [The Complete Protocol: Advances in Personalized Assessment and Treatment Delivery](https://plminstitute.org/events/the-complete-protocol-advances-in-personalized-assessment-and-treatment-delivery/) - Description: As the integrative medicine landscape evolves, it has become increasingly challenging for clinicians to navigate advances in personalized assessment options and tools for treatment delivery. In this presentation, we’ll disrupt the conventional model of care and highlight new advances in personalized medicine, such as nutrigenomic testing, individualized dietary assessment, and innovative technology for treatment
- [RECORDING – The 10th Annual Thought Leaders Consortium The Intersection of the Intestinal Microbiome with Clinical Epinutrigenomics](https://plminstitute.org/events/recording-the-10th-annual-thought-leaders-consortium-the-intersection-of-the-intestinal-microbiome-with-clinical-epinutrigenomics/) - Clinical Epigenomics: The Connection Between Immune Aging and the Microbiome A revolution in disease prevention and reversal Should premature aging be called a disease? Believe it or not, the question of how to clinically classify aging emerged more than a decade ago. There are many points of view to consider, and it’s a discussion that

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