Gut Microbiota: The Good, The Bad, and The Ugly

 

[vimeo]https://vimeo.com/84415471[/vimeo]

 

In this video Dr. Jeffrey Bland discusses recent research into the gut microbiome. This research illustrates the systemic effects of intestinal composition on drug response, and inflammatory and immune response. Some of the research cited includes work done by the Cleveland Clinic showing certain gut microbiota may convert animal products consumed in the diet into secondary metabolites that are possibly heart-disease inducing (“the Bad”). However, research out of Europe appears to demonstrate particular gut flora may enhance the effects of chemotherapy drugs, improving efficacy (the “Good”).

 

References:

Pennisi E. Biomedicine. Cancer therapies use a little help from microbial friends. Science. 2013 Nov;342(6161):921.

Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011 Apr 7;472(7341):57-63.

3 Comments On “Gut Microbiota: The Good, The Bad, and The Ugly”

  1. Pingback: Effets – positifs ou négatifs – de notre microbiote sur notre santé | nutrition soins santé

  2. Hi Jeff, Very interesting about the upregulation of T17 and its place in the inflammatory response needed to treat some cancers. My questions would be: 1. Doesn’t chemo kill more quickly rapidly dividing cells like the gut epithelium? (rhetoric question) 2. Does chemo (especially given orally) kill at least parts of the Microbiome since they also divide fairly rapidly? 3. Would it now make sense to supplement with probiotic and commensal bacteria during chemo.? (I would think so ). but here is where it would get tricky, with or without supplementation of probiotic bacteria, won’t there be enough “leaky gut” (due to chemo effect on gut epithelia) to cause the usual problems of immune dysregulation at the lamina propria level that can lead to all sorts of problems? Include the increase stress of cancer/chemo, creating increase cortisol which can knock down the beneficial bacteria and maybe push the GALT to more of a Th2 phenotype which probably wouldn’t be good for cancer or anything for that matter. It would seem your 5R program should really be a part of all cancer therapy. As you can see, as always I have far more questions than answers. Since stopping surgery and helping with Integrative Medical program at Univ of Miami, all I do is look up articles, and the more I see the more humble I get! I hear you are coming our way in April for one of our IFM conferences. I look forward to seeing you and maybe even having a minute to chat. Sincerely, Leonard

  3. Thank you for your endless support to bring the pieces of fundamental health to the forefront!

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